Polygenic Score (PGS) ID: PGS004593

Predicted Trait
Reported Trait Preeclampsia
Mapped Trait(s) preeclampsia (EFO_0000668)
Released in PGS Catalog: Jan. 26, 2024
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Terms and Licenses
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Score Details

Score Construction
PGS Name pe
Development Method
Name PRS-CS
Parameters NR
Variants
Original Genome Build GRCh38
Number of Variants 1,102,059
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000574
Citation (link to publication) Nurkkala J et al. J Hypertens (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Multi-ancestry (including European): 100%
  • European
  • Additional Asian Ancestries
159,029 individuals (100%)
PGS Evaluation
European: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 33239696
[
  • 9,115 cases
  • , 149,914 controls
]
,
0.0 % Male samples
 European, Central Asian NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020743 PSS011387|
European Ancestry|
138,317 individuals
 PGP000574 |
Nurkkala J et al. J Hypertens (2022)
 Reported Trait: Gestational hypertension HR: 1.16 [1.14, 1.19] — — Collection year, genotyping batch, and the first 10 genetic principal components —
PPM020744 PSS011388|
European Ancestry|
136,354 individuals
 PGP000574 |
Nurkkala J et al. J Hypertens (2022)
 Reported Trait: Preeclampsia HR: 1.21 [1.18, 1.24] — — Collection year, genotyping batch, and the first 10 genetic principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011387 — —
[
  • 8,488 cases
  • , 129,829 controls
]
,
0.0 % Male samples
 — European
(Finnish)		 — FinnGen —
PSS011388 — —
[
  • 6,643 cases
  • , 129,711 controls
]
,
0.0 % Male samples
 — European
(Finnish)		 — FinnGen —