Polygenic Score (PGS) ID: PGS004687

Predicted Trait
Reported Trait Bladder cancer
Mapped Trait(s) urinary bladder carcinoma (MONDO_0004986)
Released in PGS Catalog: March 18, 2024
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Score Details

Score Construction
PGS Name bladder_cancer
Development Method
Name LDPred2
Parameters NR
Variants
Original Genome Build hg19
Number of Variants 1,077,775
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000596
Citation (link to publication) Hu J et al. JNCI Cancer Spectr (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
309,154 individuals (100%)
Score Development/Training
European: 100%
366,997 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
—
[
  • 2,072 cases
  • , 307,082 controls
]
 European
(Finnish)		 FinnGen
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 2,331 cases
  • , 364,666 controls
]
 European UKB — — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020872 PSS011431|
European Ancestry|
40,771 individuals
 PGP000596 |
Hu J et al. JNCI Cancer Spectr (2024)
 Reported Trait: Bladder cancer — AUROC: 0.5582 — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011431 — —
[
  • 257 cases
  • , 40,514 controls
]
 — European — UKB —