Polygenic Score (PGS) ID: PGS004903

Predicted Trait
Reported Trait Atopic dermatitis
Mapped Trait(s) atopic eczema (EFO_0000274)
Released in PGS Catalog: May 22, 2024
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Score Details

Score Construction
PGS Name PRS_ALL
Development Method
Name SNPs affecting protein sequence or expression of enriched genes
Parameters r2 > 0.2
Variants
Original Genome Build hg19
Number of Variants 38
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000633
Citation (link to publication) Al-Janabi A et al. J Allergy Clin Immunol (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
360,838 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST005038
Europe PMC: 29083406
 360,838 individuals European 12 cohorts
  • 23andMe
  • ,AAGC
  • ,ALSPAC
  • ,CATSS
  • ,GENEVA
  • ,GENUFAD
  • ,GERA
  • ,LifeLines
  • ,NTR
  • ,SALTY
  • ,TwinGene
  • ,UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021335 PSS011691|
European Ancestry|
3,212 individuals
 PGP000633 |
Al-Janabi A et al. J Allergy Clin Immunol (2023)
 Reported Trait: Paradoxical eczema in individuals with psoriasis — — Coefficient: 4.77 [0.58, 8.96]
p: 0.026		 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011691 — —
[
  • 88 cases
  • , 3,124 controls
]
 — European — BSTOP —