| Predicted Trait | |
| Reported Trait | Mean pressure gradient |
| Mapped Trait(s) | |
| Score Construction | |
| PGS Name | mean_gradient |
| Development Method | |
| Name | PRS-CS |
| Parameters | using summary stats after MTAG with continuous aortic valve traits. PRScs v 1.1.0, "EUR" UK Biobank LD panel, run in auto mode. |
| Variants | |
| Original Genome Build | GRCh38 |
| Number of Variants | 1,111,632 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000747 |
| Citation (link to publication) | Kany S et al. Nat Genet (2025) |
| Ancestry Distribution | |
| Score Development/Training | European: 100% 98,645 individuals (100%) |
| PGS Evaluation | European: 100% 1 Sample Sets |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| — | 98,645 individuals | European | NR | measured phenotype from UK Biobank MRI | — | — | — | The disease-based aortic stenosis GWAS used for MTAG is from a meta-analysis including data from Chen et al. (13,765 cases; 640,102 controls)19, from Small et al. (14,451 cases; 398,544 controls)6, from all UK Biobank participants who did not undergo cMRI (5,038 cases; 412,301 controls), and from the freeze 12 of FinnGen (12,398 cases; 487,930 controls). The Chen, et al, and UK Biobank analyses had sample overlap, which was accounted for in our analyses. Sample size refers to effective sample size after MTAG. |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM022738 | PSS012068| European Ancestry| 244,450 individuals |
PGP000747 | Kany S et al. Nat Genet (2025) |
Reported Trait: incident aortic stenosis | HR: 1.53 [1.4, 1.66] | — | — | self-reported sex, age at DNA collection, age2 at DNA collection, and the first five principal components of genetic ancestry. | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS012068 | incident aortic stenosis (using ICD and CPT codes) | — | [
|
— | European | — | AllofUs | — |