Polygenic Score (PGS) ID: PGS012560

Predicted Trait
Reported Trait Fibromyalgia
Mapped Trait(s) fibromyalgia (MONDO_0005546)
Additional Trait Information ICD-10 M79.9
Released in PGS Catalog: Aug. 26, 2026
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Score Details

Score Construction
PGS Name fibromyalgia_multiancestry
Development Method
Name PRS-CS
Parameters n = effective sample size, n_iter = 10000, n_burnin = 5000
Variants
Original Genome Build GRCh37
Number of Variants 1,118,760
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000801
Citation (link to publication) Kerrebijn I et al. Nat Med (2026)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 88.9%
African: 5.3%
Hispanic or Latin American: 3.7%
Multi-ancestry (excluding European): 2.1%
  • Additional Asian Ancestries
  • South Asian
2,125,587 individuals (100%)
PGS Evaluation
African: 33.3%
European: 33.3%
South Asian: 33.3%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
—
[
  • 2,356 cases
  • , 110,672 controls
]
 African unspecified AllofUs, MGI, NashBio
—
[
  • 1,738 cases
  • , 76,341 controls
]
 Hispanic or Latin American
(admixed American)		 AllofUs
—
[
  • 1,148 cases
  • , 42,626 controls
]
 Central Asian, South Asian G&H
—
[
  • 42,167 cases
  • , 1,848,539 controls
]
 European 10 cohorts
  • AllofUs
  • ,CHB
  • ,DBDS
  • ,EB
  • ,FinnGen
  • ,IHCS
  • ,MGBB
  • ,MGI
  • ,NashBio
  • ,deCODE

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030689 PSS012250|
European Ancestry|
422,581 individuals
 PGP000801 |
Kerrebijn I et al. Nat Med (2026)
 Reported Trait: incident fibromyalgia cases — AUROC: 0.59 — — —
PPM030691 PSS012251|
South Asian Ancestry|
8,942 individuals
 PGP000801 |
Kerrebijn I et al. Nat Med (2026)
 Reported Trait: incident fibromyalgia cases — AUROC: 0.55 — — —
PPM030690 PSS012249|
African Ancestry|
6,645 individuals
 PGP000801 |
Kerrebijn I et al. Nat Med (2026)
 Reported Trait: incident fibromyalgia cases — AUROC: 0.55 — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012251 ICD 10 - M79.7 —
[
  • 226 cases
  • , 8,716 controls
]
 — South Asian — UKB —
PSS012249 ICD 10 - M79.7 —
[
  • 161 cases
  • , 6,484 controls
]
 — African unspecified — UKB —
PSS012250 ICD 10 - M79.7 —
[
  • 6,833 cases
  • , 415,748 controls
]
 — European — UKB —