Polygenic Score (PGS) ID: PGS012561

Predicted Trait
Reported Trait Fibromyalgia
Mapped Trait(s) fibromyalgia (MONDO_0005546)
Additional Trait Information ICD-10 M79.9
Released in PGS Catalog: Aug. 26, 2026
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Score Details

Score Construction
PGS Name fibromyalgia_European
Development Method
Name PRS-CS
Parameters n = effective sample size, n_iter = 10000, n_burnin = 5000
Variants
Original Genome Build GRCh37
Number of Variants 1,113,197
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000801
Citation (link to publication) Kerrebijn I et al. Nat Med (2026)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
1,890,706 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
—
[
  • 42,167 cases
  • , 1,848,539 controls
]
 European 10 cohorts
  • AllofUs
  • ,CHB
  • ,DBDS
  • ,EB
  • ,FinnGen
  • ,IHCS
  • ,MGBB
  • ,MGI
  • ,NashBio
  • ,deCODE

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030692 PSS012250|
European Ancestry|
422,581 individuals
 PGP000801 |
Kerrebijn I et al. Nat Med (2026)
 Reported Trait: incident fibromyalgia cases — AUROC: 0.59 — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012250 ICD 10 - M79.7 —
[
  • 6,833 cases
  • , 415,748 controls
]
 — European — UKB —