Polygenic Score (PGS) ID: PGS018414

Predicted Trait
Reported Trait Hearing loss (HL)
Mapped Trait(s) hearing loss disorder (MONDO_0005365)
Released in PGS Catalog: July 15, 2026
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Score Details

Score Construction
PGS Name pgshl
Development Method
Name SBayesR
Parameters NR
Variants
Original Genome Build GRCh38
Number of Variants 2,370,365
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000832
Citation (link to publication) Miao DNR et al. Hum Genomics (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
330,759 individuals (100%)
PGS Evaluation
Not Reported: 50%
Multi-ancestry (including European): 50%
  • African
  • European
  • Hispanic or Latin American
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90012115
Europe PMC: 32986727
 330,759 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM036591 PSS012317|
Multi-ancestry (including European)|
390 individuals
 PGP000832 |
Miao DNR et al. Hum Genomics (2024)
 Reported Trait: cisplatin-induced ototoxicity — — R²: 0.023
p-value: 0.00293		 — —
PPM036593 PSS012318|
Ancestry Not Reported|
238 individuals
 PGP000832 |
Miao DNR et al. Hum Genomics (2024)
 Reported Trait: cisplatin-induced ototoxicity — — R²: 0.006
p-value: 0.52		 age at diagnosis , protocol (SJMB96 or SJMB03) , 10 principal components , craniospinal irradiation dose (CSI dose)*score —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012317 — —
[
  • 168 cases
  • , 222 controls
]
,
46.0 % Male samples
 — African American or Afro-Caribbean, European, Hispanic or Latin American 92% European and 8% non-European ancestry (African-American/African-Caribbean and Latin American) PCL —
PSS012318 — —
[
  • 93 cases
  • , 145 controls
]
,
62.0 % Male samples
 — Not reported — NR —