| Predicted Trait | |
| Reported Trait | Waist circumference |
| Mapped Trait(s) | waist circumference (OBA_1001085) |
| Score Construction | |
| PGS Name | GRS91_WC |
| Development Method | |
| Name | Genome-Wide significant SNPs |
| Parameters | p<5E-08, linkage equilibrium and MAF < 0.1 |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 91 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000846 |
| Citation (link to publication) | AlBaloul AH et al. BMC Public Health (2024) |
| Ancestry Distribution | |
| Source of Variant Associations (GWAS) | European: 100% 133,723 individuals (100%) |
| PGS Evaluation | European: 100% 2 Sample Sets |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
|---|---|---|---|
GWAS Catalog: GCST002063 Europe PMC: 23754948 |
133,723 individuals | European | NR |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM038151 | PSS013843| European Ancestry| 6,502 individuals |
PGP000846 | AlBaloul AH et al. BMC Public Health (2024) |
Reported Trait: Waist circumference | — | — | Hazard ratio (HR, high vs low tertile): 1.57 [1.28, 1.91] | age, sex, BMI and PAL | — |
| PPM038152 | PSS013844| European Ancestry| 171,129 individuals |
PGP000846 | AlBaloul AH et al. BMC Public Health (2024) |
Reported Trait: Waist circumference | — | — | Hazard ratio (HR, high vs low tertile): 1.58 [1.52, 1.63] | age, sex, BMI and PAL | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS013843 | — | — | 6,502 individuals, 60.6 % Male samples |
— | European | — | Airwave | — |
| PSS013844 | — | — | 171,129 individuals, 44.9 % Male samples |
— | European | — | UKB | — |