Experimental Factor Ontology (EFO) Information | |
Identifier | EFO_0003884 |
Description | Impairment of the renal function secondary to chronic kidney damage persisting for three or more months. [NCIT: C80078] | Trait category |
Other disease
|
Synonyms |
34 synonyms
|
Mapped term(s) |
16 mapped terms
|
Polygenic Score (PGS) ID | PGS Name | PGS Publication (PGP) ID | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants | PGS Scoring File (FTP Link) |
---|---|---|---|---|---|---|
PGS000728 | CKD_PGS | PGP000137 Ritchie SC et al. bioRxiv (2019) Pre |
Chronic kidney disease | chronic kidney disease | 1,958,860 | http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000728/ScoringFiles/PGS000728.txt.gz |
PGS Performance Metric ID (PPM ID) |
Evaluated Score |
PGS Sample Set ID (PSS ID) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
PGS Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|---|
PPM001669 | PGS000728 (CKD_PGS) |
PSS000870 | PGP000137 Ritchie SC et al. bioRxiv (2019) Pre |
Reported Trait: Estimated Glomerular Filtration Rate (eGFR) | β: -0.9 [-1.45, -0.36] | — | — | age, sex, 10 genetic PCs | — |
PGS Sample Set ID (PSS ID) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS000870 | Serum creatinine was quantified by Metabolon HD4 metabolomics in mg/dL units, and adjusted for sample measurement batch, sample measurement plate, and days between blood draw and sample processing. Subsequently, eGFR was quantified from serum creatinine using the CKD-EPI equation | — | 3,037 individuals, 51.0 % Male samples |
Median = 44.0 years Iqr = [30.5, 54.7] years |
European | — | INTERVAL | — |