Trait: mean corpuscular volume

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004526
Description A mean corpuscular volume is the result of calculation of the mean volume of erythrocytes in a blood sample.
Trait category
Hematological measurement
Synonyms 2 synonyms
  • MCV
  • mean cell volume
Mapped term(s) MedDRA:10027008

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000101
(mcv)
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Mean corpuscular volume mean corpuscular volume 739
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000101/ScoringFiles/PGS000101.txt.gz
PGS000176
(mcv)
PGP000078 |
Vuckovic D et al. Cell (2020)
Mean corpuscular volume mean corpuscular volume 685
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000176/ScoringFiles/PGS000176.txt.gz
PGS000181
(mscv)
PGP000078 |
Vuckovic D et al. Cell (2020)
Mean sphered corpuscular volume mean corpuscular volume 761
-
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000181/ScoringFiles/PGS000181.txt.gz
PGS001220
(GBE_INI30040)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Mean corpuscular volume mean corpuscular volume 17,311
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001220/ScoringFiles/PGS001220.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000234 PGS000101
(mcv)
PSS000166|
European Ancestry|
81,431 individuals
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Reported Trait: Mean corpuscular volume Pearson correlation coefficent (r): 0.537 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM000235 PGS000101
(mcv)
PSS000140|
European Ancestry|
40,080 individuals
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Reported Trait: Mean corpuscular volume Pearson correlation coefficent (r): 0.4384 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment)
PPM000553 PGS000176
(mcv)
PSS000290|
European Ancestry|
2,314 individuals
PGP000078 |
Vuckovic D et al. Cell (2020)
Reported Trait: Mean corpuscular volume : 0.1665 sex, age, 10 genetic PCs
PPM000532 PGS000176
(mcv)
PSS000291|
European Ancestry|
39,260 individuals
PGP000078 |
Vuckovic D et al. Cell (2020)
Reported Trait: Mean corpuscular volume : 0.15931 sex, age, 10 genetic PCs
PPM001774 PGS000176
(mcv)
PSS000911|
Greater Middle Eastern Ancestry|
13,989 individuals
PGP000147 |
Thareja G et al. Nat Commun (2021)
|Ext.
Reported Trait: Mean corpuscular volume Pearson correlation coefficent (r): 0.23
PPM004623 PGS001220
(GBE_INI30040)
PSS003086|
African Ancestry|
6,139 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Mean corpuscular volume : 0.03915
Incremental R2 (full-covars): 0.01322
PGS R2 (no covariates): 0.01574
age, sex Genotype PCs
PPM004624 PGS001220
(GBE_INI30040)
PSS003087|
East Asian Ancestry|
1,655 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Mean corpuscular volume : 0.09514
Incremental R2 (full-covars): 0.04115
PGS R2 (no covariates): 0.06236
age, sex Genotype PCs
PPM004625 PGS001220
(GBE_INI30040)
PSS003088|
European Ancestry|
24,175 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Mean corpuscular volume : 0.20619
Incremental R2 (full-covars): 0.15849
PGS R2 (no covariates): 0.17295
age, sex Genotype PCs
PPM004626 PGS001220
(GBE_INI30040)
PSS003089|
South Asian Ancestry|
7,520 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Mean corpuscular volume : 0.12918
Incremental R2 (full-covars): 0.0792
PGS R2 (no covariates): 0.08422
age, sex Genotype PCs
PPM004627 PGS001220
(GBE_INI30040)
PSS003090|
European Ancestry|
65,638 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Mean corpuscular volume : 0.21449
Incremental R2 (full-covars): 0.19853
PGS R2 (no covariates): 0.20021
age, sex Genotype PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS003088 24,175 individuals European non-white British ancestry UKB
PSS003089 7,520 individuals South Asian UKB
PSS000166 81,431 individuals,
46.0 % Male samples
Mean = 57.26 years
Range = [40.15, 71.1] years
European UKB
PSS003090 65,638 individuals European white British ancestry UKB
PSS000290 2,314 individuals European
(French Canadian)
CARTaGENE
PSS000291 39,260 individuals European INTERVAL
PSS000140 40,080 individuals,
50.0 % Male samples
Mean = 43.82 years
Range = [18.0, 76.4] years
European INTERVAL
PSS000911 13,989 individuals Greater Middle Eastern (Middle Eastern, North African or Persian)
(Qatari)
QBB
PSS003086 6,139 individuals African unspecified UKB
PSS003087 1,655 individuals East Asian UKB