Trait: mean corpuscular volume

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004526
Description
  • A mean corpuscular volume is the result of calculation of the mean volume of erythrocytes in a blood sample.
Trait category
Hematological measurement
Synonyms 2 synonyms
  • MCV
  • mean cell volume

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Number of Variants PGS Scoring File (FTP Link)
PGS000101 mcv PGP000051
Xu Y et al. bioRxiv (2020)
Pre
Mean corpuscular volume 739 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000101/ScoringFiles/PGS000101.txt.gz
PGS000176 mcv PGP000078
Vuckovic D et al. medRxiv (2020)
Pre
Mean corpuscular volume 685 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000176/ScoringFiles/PGS000176.txt.gz
PGS000181 mscv PGP000078
Vuckovic D et al. medRxiv (2020)
Pre
Mean sphered corpuscular volume 761 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000181/ScoringFiles/PGS000181.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000234 PGS000101 (mcv) PSS000166 PGP000051
Xu Y et al. (2020)
Pre
Reported Trait: Mean corpuscular volume Pearson correlation coefficent (r): 0.537 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM000235 PGS000101 (mcv) PSS000140 PGP000051
Xu Y et al. (2020)
Pre
Reported Trait: Mean corpuscular volume Pearson correlation coefficent (r): 0.4384 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment)
PPM000553 PGS000176 (mcv) PSS000290 PGP000078
Vuckovic D et al. (2020)
Pre
Reported Trait: Mean corpuscular volume : 0.166499089849 sex, age, 10 genetic PCs
PPM000532 PGS000176 (mcv) PSS000291 PGP000078
Vuckovic D et al. (2020)
Pre
Reported Trait: Mean corpuscular volume : 0.159305126007935 sex, age, 10 genetic PCs

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000140 40,080 individuals,
50.0 % Male samples
Mean = 43.82 years
Range = [18.0, 76.4] years
European INTERVAL
PSS000166 81,431 individuals,
46.0 % Male samples
Mean = 57.26 years
Range = [40.15, 71.1] years
European UKB
PSS000290 2,314 individuals European
(French Canadian)
CARTaGENE
PSS000291 39,260 individuals European INTERVAL