Trait: mean corpuscular hemoglobin

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004527
Description
  • The MCH is the average mass of hemoglobin per red blood cell in a sample of blood and is calculated by dividing the total mass of hemoglobin by the RBC count
Trait category
Hematological measurement
Synonyms 2 synonyms
  • MCH
  • mean corpuscular haemoglobin

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Number of Variants PGS Scoring File (FTP Link)
PGS000099 mch PGP000051
Xu Y et al. bioRxiv (2020)
Mean corpuscular hemoglobin 682 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000099/ScoringFiles/PGS000099.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000230 PGS000099 (mch) PSS000164 PGP000051
Xu Y et al. (2020)
Reported Trait: Mean corpuscular hemoglobin Pearson correlation coefficent (r): 0.5252 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM000231 PGS000099 (mch) PSS000138 PGP000051
Xu Y et al. (2020)
Reported Trait: Mean corpuscular hemoglobin Pearson correlation coefficent (r): 0.4583 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment)

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000164 81,303 individuals,
46.0 % Male samples
Mean = 57.27 years
Range = [39.99, 70.44] years
European UKB
PSS000138 40,108 individuals,
50.0 % Male samples
Mean = 43.85 years
Range = [18.0, 76.4] years
European INTERVAL