Trait: mean corpuscular hemoglobin concentration

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004528
Description
  • The mean corpuscular hemoglobin concentration is a measure of the concentration of hemoglobin in a given volume of packed red blood cell
Trait category
Hematological measurement
Synonyms 6 synonyms
  • CHCM
  • Erythrocyte Corpuscular Hemoglobin Concentration Mean
  • Corpuscular HGB Concentration Mean
  • MCHC
  • mean corpuscular haemoglobin concentration
  • Corpuscular Hemoglobin Concentration Mean
Mapped term(s) NCIt:C139067

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Number of Variants PGS Scoring File (FTP Link)
PGS000100 mchc PGP000051
Xu Y et al. bioRxiv (2020)
Pre
Mean corpuscular hemoglobin concentration 252 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000100/ScoringFiles/PGS000100.txt.gz
PGS000175 mchc PGP000078
Vuckovic D et al. medRxiv (2020)
Pre
Mean corpuscular hemoglobin concentration 224 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000175/ScoringFiles/PGS000175.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000232 PGS000100 (mchc) PSS000165 PGP000051
Xu Y et al. (2020)
Pre
Reported Trait: Mean corpuscular hemoglobin concentration Pearson correlation coefficent (r): 0.2755 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM000233 PGS000100 (mchc) PSS000139 PGP000051
Xu Y et al. (2020)
Pre
Reported Trait: Mean corpuscular hemoglobin concentration Pearson correlation coefficent (r): 0.2642 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment)
PPM000551 PGS000175 (mchc) PSS000290 PGP000078
Vuckovic D et al. (2020)
Pre
Reported Trait: Mean corpuscular hemoglobin concentration : 0.04795587553689 sex, age, 10 genetic PCs
PPM000531 PGS000175 (mchc) PSS000291 PGP000078
Vuckovic D et al. (2020)
Pre
Reported Trait: Mean corpuscular hemoglobin concentration : 0.0515942741395813 sex, age, 10 genetic PCs

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000165 81,570 individuals,
46.0 % Male samples
Mean = 57.27 years
Range = [39.98, 70.7] years
European UKB
PSS000291 39,260 individuals European INTERVAL
PSS000290 2,314 individuals European
(French Canadian)
CARTaGENE
PSS000139 40,265 individuals,
50.0 % Male samples
Mean = 43.83 years
Range = [18.0, 76.4] years
European INTERVAL