Trait: total blood protein measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004536
Description
  • A total blood protein measurement is a quantification of protein in a blood sample. It is used as a marker for disease and nutrition. It is performed in the liquid portion of blood and typically measures albumin and globulin.
Trait category
Hematological measurement
Synonyms 2 synonyms
  • TBP
  • serum total protein

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000698 snpnet.Total_protein PGP000128 Sinnott-Armstrong N et al. Nat Genet (2021) Total protein [g/L] total blood protein measurement 16,420 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000698/ScoringFiles/PGS000698.txt.gz - Check Terms/Licenses

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001496 PGS000698
(snpnet.Total_protein)
PSS000769 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Total protein [g/L] : 0.11654
Spearman's ρ: 0.282
Age, sex, PCs(1-40)
PPM001461 PGS000698
(snpnet.Total_protein)
PSS000768 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Total protein [g/L] : 0.09275
Spearman's ρ: 0.247
Age, sex, PCs(1-40)
PPM001566 PGS000698
(snpnet.Total_protein)
PSS000771 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Total protein [g/L] : 0.11218
Spearman's ρ: 0.284
Age, sex, PCs(1-40)
PPM001531 PGS000698
(snpnet.Total_protein)
PSS000770 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Total protein [g/L] : 0.10522
Spearman's ρ: 0.258
Age, sex, PCs(1-40)
PPM001426 PGS000698
(snpnet.Total_protein)
PSS000767 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Total protein [g/L] : 0.04363
Spearman's ρ: 0.144
Age, sex, PCs(1-40)

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000767 5,573 individuals African unspecified UKB
PSS000768 984 individuals East Asian UKB
PSS000769 21,516 individuals European Non-British White UKB
PSS000770 6,687 individuals South Asian UKB
PSS000771 58,196 individuals European
(British)
UKB