Trait: HbA1c measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004541
Description
  • A quantification of glycated A1c hemoglobin in blood used as an index for blood glucose level over several months.
Trait category
Hematological measurement
Other measurement
Synonyms 10 synonyms
  • Glycosylated Hemoglobin Measurement
  • A1c measurement
  • A1C measurement
  • Hemoglobin A1C
  • glycosylated Haemoglobin A level
  • glycosylated Hemoglobin A level
  • glycated hemoglobin levels
  • HbA1c levels
  • Glycosylated Hemoglobin
  • HBA1C
Mapped term(s) NCIt:C64849

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Number of Variants PGS Scoring File (FTP Link)
PGS000132 GS-G-EAS PGP000064
Wheeler E et al. PLoS Med (2017)
Hemoglobin A1c 19 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000132/ScoringFiles/PGS000132.txt.gz
PGS000127 GS-E-EUR PGP000064
Wheeler E et al. PLoS Med (2017)
Hemoglobin A1c 21 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000127/ScoringFiles/PGS000127.txt.gz
PGS000128 GS-E-AFR PGP000064
Wheeler E et al. PLoS Med (2017)
Hemoglobin A1c 22 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000128/ScoringFiles/PGS000128.txt.gz
PGS000129 GS-E-EAS PGP000064
Wheeler E et al. PLoS Med (2017)
Hemoglobin A1c 17 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000129/ScoringFiles/PGS000129.txt.gz
PGS000130 GS-G-EUR PGP000064
Wheeler E et al. PLoS Med (2017)
Hemoglobin A1c 19 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000130/ScoringFiles/PGS000130.txt.gz
PGS000131 GS-G-AFR PGP000064
Wheeler E et al. PLoS Med (2017)
Hemoglobin A1c 19 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000131/ScoringFiles/PGS000131.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000407 PGS000127 (GS-E-EUR) PSS000236 PGP000064
Wheeler E et al. (2017)
Reported Trait: Incident type 2 diabetes OR: 1.0[0.99, 1.01] age, sex
PPM000411 PGS000131 (GS-G-AFR) PSS000234 PGP000064
Wheeler E et al. (2017)
Reported Trait: Incident type 2 diabetes OR: 1.0[0.95, 1.05] age, sex
PPM000412 PGS000132 (GS-G-EAS) PSS000235 PGP000064
Wheeler E et al. (2017)
Reported Trait: Incident type 2 diabetes OR: 1.05[1.02, 1.07] age, sex
PPM000410 PGS000130 (GS-G-EUR) PSS000236 PGP000064
Wheeler E et al. (2017)
Reported Trait: Incident type 2 diabetes OR: 1.05[1.04, 1.06] age, sex
PPM000409 PGS000129 (GS-E-EAS) PSS000235 PGP000064
Wheeler E et al. (2017)
Reported Trait: Incident type 2 diabetes OR: 1.02[0.99, 1.05] age, sex
PPM000408 PGS000128 (GS-E-AFR) PSS000234 PGP000064
Wheeler E et al. (2017)
Reported Trait: Incident type 2 diabetes OR: 0.98[0.96, 1.0] age, sex

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000234 Incident type 2 diabtes defined as fasting glucose >= 7 mmol/L, 2 hour glucose >= 11.1 mmol/L, antidiabetic medication use, or a physician diagnosis of type 2 diabetes Range = [10.0, 15.0] years
[
  • 262 cases
  • , 1,644 controls
]
,
0.38 % Male samples
Mean = 57.4 years
Sd = 7.43 years
African unspecified ARIC, MESA Partial overlap with discovery GWAS
PSS000235 Incident type 2 diabtes defined as fasting glucose >= 7 mmol/L, 2 hour glucose >= 11.1 mmol/L, antidiabetic medication use, or a physician diagnosis of type 2 diabetes Range = [10.0, 15.0] years
[
  • 2,391 cases
  • , 2,682 controls
]
,
0.47 % Male samples
Mean = 55.6 years
Sd = 7.37 years
East Asian MESA, SCHS Partial overlap with discovery GWAS
PSS000236 Incident type 2 diabtes defined as fasting glucose >= 7 mmol/L, 2 hour glucose >= 11.1 mmol/L, antidiabetic medication use, or a physician diagnosis of type 2 diabetes Range = [10.0, 15.0] years
[
  • 13,145 cases
  • , 24,212 controls
]
,
0.43 % Male samples
Mean = 54.63 years
Sd = 8.27 years
European ARIC, FHS, InterAct, MESA Partial overlap with discovery GWAS