Trait: bilirubin measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004570
Description
  • A bilirubin measurement is a quantification of bilirubin typically measured in serum.
Trait category
Other measurement
Synonyms bilirubin levels
Mapped term(s) SNOMEDCT:302787001

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000681 snpnet.Direct_bilirubin PGP000128 Sinnott-Armstrong N et al. Nat Genet (2021) Direct bilirubin [umol/L] bilirubin measurement 3,104 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000681/ScoringFiles/PGS000681.txt.gz - Check Terms/Licenses
PGS000697 snpnet.Total_bilirubin PGP000128 Sinnott-Armstrong N et al. Nat Genet (2021) Total bilirubin [umol/L] bilirubin measurement 1,159 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000697/ScoringFiles/PGS000697.txt.gz - Check Terms/Licenses

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID) 		Evaluated Score PGS Sample Set ID
(PSS ID) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001409 PGS000681
(snpnet.Direct_bilirubin)
 PSS000684 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Direct bilirubin [umol/L] — — R²: 0.27938
Spearman's ρ: 0.469		 Age, sex, PCs(1-40) —
PPM001444 PGS000681
(snpnet.Direct_bilirubin)
 PSS000685 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Direct bilirubin [umol/L] — — R²: 0.15786
Spearman's ρ: 0.291		 Age, sex, PCs(1-40) —
PPM001479 PGS000681
(snpnet.Direct_bilirubin)
 PSS000686 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Direct bilirubin [umol/L] — — R²: 0.33072
Spearman's ρ: 0.453		 Age, sex, PCs(1-40) —
PPM001514 PGS000681
(snpnet.Direct_bilirubin)
 PSS000687 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Direct bilirubin [umol/L] — — R²: 0.3015
Spearman's ρ: 0.452		 Age, sex, PCs(1-40) —
PPM001549 PGS000681
(snpnet.Direct_bilirubin)
 PSS000688 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Direct bilirubin [umol/L] — — R²: 0.34294
Spearman's ρ: 0.46		 Age, sex, PCs(1-40) —
PPM001460 PGS000697
(snpnet.Total_bilirubin)
 PSS000763 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Total bilirubin [umol/L] — — R²: 0.2156
Spearman's ρ: 0.347		 Age, sex, PCs(1-40) —
PPM001495 PGS000697
(snpnet.Total_bilirubin)
 PSS000764 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Total bilirubin [umol/L] — — R²: 0.42641
Spearman's ρ: 0.523		 Age, sex, PCs(1-40) —
PPM001530 PGS000697
(snpnet.Total_bilirubin)
 PSS000765 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Total bilirubin [umol/L] — — R²: 0.43693
Spearman's ρ: 0.548		 Age, sex, PCs(1-40) —
PPM001565 PGS000697
(snpnet.Total_bilirubin)
 PSS000766 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Total bilirubin [umol/L] — — R²: 0.44377
Spearman's ρ: 0.533		 Age, sex, PCs(1-40) —
PPM001425 PGS000697
(snpnet.Total_bilirubin)
 PSS000762 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Total bilirubin [umol/L] — — R²: 0.38749
Spearman's ρ: 0.551		 Age, sex, PCs(1-40) —

Evaluated Samples

PGS Sample Set ID
(PSS ID) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000684 — — 5,007 individuals — African unspecified — UKB —
PSS000685 — — 915 individuals — East Asian — UKB —
PSS000686 — — 20,094 individuals — European Non-British White UKB —
PSS000687 — — 6,088 individuals — South Asian — UKB —
PSS000688 — — 54,161 individuals — European
(British)		 — UKB —
PSS000762 — — 5,978 individuals — African unspecified — UKB —
PSS000763 — — 1,069 individuals — East Asian — UKB —
PSS000764 — — 23,472 individuals — European Non-British White UKB —
PSS000765 — — 7,313 individuals — South Asian — UKB —
PSS000766 — — 63,531 individuals — European
(British)		 — UKB —