Trait: apolipoprotein B measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004615
Description
  • The measurement of ApoB in blood. Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor, and is upregulated in response to enterovirus 71.
Trait category
Lipid or lipoprotein measurement
Mapped term(s) NCIt:C74734

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000672 snpnet.Apolipoprotein_B_adjstatins PGP000128 Sinnott-Armstrong N et al. Nat Genet (2021) Apolipoprotein B [g/L] (statin adjusted) apolipoprotein B measurement 18,666 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000672/ScoringFiles/PGS000672.txt.gz - Check Terms/Licenses

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001505 PGS000672
(snpnet.Apolipoprotein_B_adjstatins)
PSS000645 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Apolipoprotein B [g/L] (statin adjusted) : 0.15714
Spearman's ρ: 0.335
Age, sex, PCs(1-40)
PPM001435 PGS000672
(snpnet.Apolipoprotein_B_adjstatins)
PSS000643 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Apolipoprotein B [g/L] (statin adjusted) : 0.17749
Spearman's ρ: 0.346
Age, sex, PCs(1-40)
PPM001540 PGS000672
(snpnet.Apolipoprotein_B_adjstatins)
PSS000646 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Apolipoprotein B [g/L] (statin adjusted) : 0.30182
Spearman's ρ: 0.483
Age, sex, PCs(1-40)
PPM001470 PGS000672
(snpnet.Apolipoprotein_B_adjstatins)
PSS000644 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Apolipoprotein B [g/L] (statin adjusted) : 0.29807
Spearman's ρ: 0.467
Age, sex, PCs(1-40)
PPM001400 PGS000672
(snpnet.Apolipoprotein_B_adjstatins)
PSS000642 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Apolipoprotein B [g/L] (statin adjusted) : 0.15686
Spearman's ρ: 0.318
Age, sex, PCs(1-40)

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000642 5,962 individuals African unspecified UKB
PSS000643 1,074 individuals East Asian UKB
PSS000644 23,448 individuals European Non-British White UKB
PSS000645 7,275 individuals South Asian UKB
PSS000646 63,491 individuals European
(British)
UKB