Trait: cystatin C measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004617
Description is a quantification of serum cystatin C C (formerly gamma trace, post-gamma-globulin or neuroendocrine basic polypeptide),[1] a protein encoded by the CST3 gene, is mainly used as a biomarker of kidney function and kidney disease.
Trait category
Other measurement
Mapped terms 2 mapped terms
  • NCIt:C92290
  • uniprot:P01034

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000680
(snpnet.Cystatin_C)
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Cystatin C [mg/L] cystatin C measurement 24,487
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000680/ScoringFiles/PGS000680.txt.gz - Check Terms/Licenses
PGS001947
(portability-PLR_log_cystatinC)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Cystatin C cystatin C measurement 84,459
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001947/ScoringFiles/PGS001947.txt.gz
PGS002165
(portability-ldpred2_log_cystatinC)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Cystatin C cystatin C measurement 781,302
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002165/ScoringFiles/PGS002165.txt.gz
PGS003279
(ExPRSweb_CysC_30720-irnt_LASSOSUM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Cystatin C cystatin C measurement 879,560
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003279/ScoringFiles/PGS003279.txt.gz
PGS003280
(ExPRSweb_CysC_30720-irnt_PT_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Cystatin C cystatin C measurement 346
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003280/ScoringFiles/PGS003280.txt.gz
PGS003281
(ExPRSweb_CysC_30720-irnt_PLINK_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Cystatin C cystatin C measurement 415
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003281/ScoringFiles/PGS003281.txt.gz
PGS003282
(ExPRSweb_CysC_30720-irnt_DBSLMM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Cystatin C cystatin C measurement 7,451,904
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003282/ScoringFiles/PGS003282.txt.gz
PGS003283
(ExPRSweb_CysC_30720-irnt_PRSCS_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Cystatin C cystatin C measurement 1,113,831
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003283/ScoringFiles/PGS003283.txt.gz
PGS003284
(ExPRSweb_CysC_30720-raw_LASSOSUM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Cystatin C cystatin C measurement 735,756
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003284/ScoringFiles/PGS003284.txt.gz
PGS003285
(ExPRSweb_CysC_30720-raw_PT_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Cystatin C cystatin C measurement 931
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003285/ScoringFiles/PGS003285.txt.gz
PGS003286
(ExPRSweb_CysC_30720-raw_PLINK_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Cystatin C cystatin C measurement 1,057
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003286/ScoringFiles/PGS003286.txt.gz
PGS003287
(ExPRSweb_CysC_30720-raw_DBSLMM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Cystatin C cystatin C measurement 7,451,726
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003287/ScoringFiles/PGS003287.txt.gz
PGS003288
(ExPRSweb_CysC_30720-raw_PRSCS_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Cystatin C cystatin C measurement 1,113,831
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003288/ScoringFiles/PGS003288.txt.gz
PGS003289
(ExPRSweb_CysC_CKDGen-1000Genomes-DiscoveryMeta-eGFRcys_LASSOSUM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 162,595
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003289/ScoringFiles/PGS003289.txt.gz
PGS003290
(ExPRSweb_CysC_CKDGen-1000Genomes-DiscoveryMeta-eGFRcys_PT_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 48
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003290/ScoringFiles/PGS003290.txt.gz
PGS003291
(ExPRSweb_CysC_CKDGen-1000Genomes-DiscoveryMeta-eGFRcys_PLINK_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 49
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003291/ScoringFiles/PGS003291.txt.gz
PGS003292
(ExPRSweb_CysC_CKDGen-1000Genomes-DiscoveryMeta-eGFRcys_DBSLMM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 88,980
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003292/ScoringFiles/PGS003292.txt.gz
PGS003293
(ExPRSweb_CysC_CKDGen-1000Genomes-DiscoveryMeta-eGFRcys_PRSCS_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 1,114,109
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003293/ScoringFiles/PGS003293.txt.gz
PGS003294
(ExPRSweb_CysC_eGFRcys-overall-EA_LASSOSUM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 1,954
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003294/ScoringFiles/PGS003294.txt.gz
PGS003295
(ExPRSweb_CysC_eGFRcys-overall-EA_PT_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 42
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003295/ScoringFiles/PGS003295.txt.gz
PGS003296
(ExPRSweb_CysC_eGFRcys-overall-EA_PLINK_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 87
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003296/ScoringFiles/PGS003296.txt.gz
PGS003297
(ExPRSweb_CysC_eGFRcys-overall-EA_DBSLMM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 7,372
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003297/ScoringFiles/PGS003297.txt.gz
PGS003298
(ExPRSweb_CysC_eGFRcys-overall-EA_PRSCS_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 16,681
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003298/ScoringFiles/PGS003298.txt.gz
PGS003299
(ExPRSweb_CysC_eGFRcys-overall-IV-2GC_LASSOSUM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 62,133
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003299/ScoringFiles/PGS003299.txt.gz
PGS003300
(ExPRSweb_CysC_eGFRcys-overall-IV-2GC_PT_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 203
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003300/ScoringFiles/PGS003300.txt.gz
PGS003301
(ExPRSweb_CysC_eGFRcys-overall-IV-2GC_PLINK_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 204
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003301/ScoringFiles/PGS003301.txt.gz
PGS003302
(ExPRSweb_CysC_eGFRcys-overall-IV-2GC_DBSLMM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 695,827
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003302/ScoringFiles/PGS003302.txt.gz
PGS003303
(ExPRSweb_CysC_eGFRcys-overall-IV-2GC_PRSCS_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 933,013
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003303/ScoringFiles/PGS003303.txt.gz
PGS003304
(ExPRSweb_CysC_CKDGen-1000Genomes-DiscoveryMeta-eGFRcys_LASSOSUM_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 174,315
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003304/ScoringFiles/PGS003304.txt.gz
PGS003305
(ExPRSweb_CysC_CKDGen-1000Genomes-DiscoveryMeta-eGFRcys_PT_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 15
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003305/ScoringFiles/PGS003305.txt.gz
PGS003306
(ExPRSweb_CysC_CKDGen-1000Genomes-DiscoveryMeta-eGFRcys_PLINK_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 15
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003306/ScoringFiles/PGS003306.txt.gz
PGS003307
(ExPRSweb_CysC_CKDGen-1000Genomes-DiscoveryMeta-eGFRcys_DBSLMM_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 11,672
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003307/ScoringFiles/PGS003307.txt.gz
PGS003308
(ExPRSweb_CysC_CKDGen-1000Genomes-DiscoveryMeta-eGFRcys_PRSCS_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 1,114,999
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003308/ScoringFiles/PGS003308.txt.gz
PGS003309
(ExPRSweb_CysC_eGFRcys-overall-EA_LASSOSUM_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 1,954
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003309/ScoringFiles/PGS003309.txt.gz
PGS003310
(ExPRSweb_CysC_eGFRcys-overall-EA_PT_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 6
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003310/ScoringFiles/PGS003310.txt.gz
PGS003311
(ExPRSweb_CysC_eGFRcys-overall-EA_PLINK_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 7
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003311/ScoringFiles/PGS003311.txt.gz
PGS003312
(ExPRSweb_CysC_eGFRcys-overall-EA_DBSLMM_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 6,375
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003312/ScoringFiles/PGS003312.txt.gz
PGS003313
(ExPRSweb_CysC_eGFRcys-overall-EA_PRSCS_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 16,685
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003313/ScoringFiles/PGS003313.txt.gz
PGS003314
(ExPRSweb_CysC_eGFRcys-overall-IV-2GC_LASSOSUM_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 62,626
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003314/ScoringFiles/PGS003314.txt.gz
PGS003315
(ExPRSweb_CysC_eGFRcys-overall-IV-2GC_PT_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 2
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003315/ScoringFiles/PGS003315.txt.gz
PGS003316
(ExPRSweb_CysC_eGFRcys-overall-IV-2GC_PLINK_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 2
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003316/ScoringFiles/PGS003316.txt.gz
PGS003317
(ExPRSweb_CysC_eGFRcys-overall-IV-2GC_DBSLMM_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 594,334
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003317/ScoringFiles/PGS003317.txt.gz
PGS003318
(ExPRSweb_CysC_eGFRcys-overall-IV-2GC_PRSCS_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 933,341
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003318/ScoringFiles/PGS003318.txt.gz
PGS003528
(cont-decay-log_cystatinC)
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Cystatin C cystatin C measurement 979,739
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003528/ScoringFiles/PGS003528.txt.gz
PGS003589
(UKB_cycproduction_EUR)
 PGP000463 |
Kleeman SO et al. Cell Genom (2023)
 Cystatin C production cystatin C measurement 1,031,527
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003589/ScoringFiles/PGS003589.txt.gz
PGS003590
(UKB_cycproduction_EUR_exome)
 PGP000463 |
Kleeman SO et al. Cell Genom (2023)
 Cystatin C production cystatin C measurement 352,549
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003590/ScoringFiles/PGS003590.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001408 PGS000680
(snpnet.Cystatin_C)
 PSS000677|
African Ancestry|
6,015 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Cystatin C [mg/L] — — R²: 0.17697
Spearman's ρ: 0.196		 Age, sex, PCs(1-40) —
PPM001443 PGS000680
(snpnet.Cystatin_C)
 PSS000678|
East Asian Ancestry|
1,082 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Cystatin C [mg/L] — — R²: 0.28853
Spearman's ρ: 0.274		 Age, sex, PCs(1-40) —
PPM001478 PGS000680
(snpnet.Cystatin_C)
 PSS000679|
European Ancestry|
23,580 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Cystatin C [mg/L] — — Spearman's ρ: 0.391
R²: 0.30498		 Age, sex, PCs(1-40) —
PPM001513 PGS000680
(snpnet.Cystatin_C)
 PSS000680|
South Asian Ancestry|
7,338 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Cystatin C [mg/L] — — R²: 0.26742
Spearman's ρ: 0.323		 Age, sex, PCs(1-40) —
PPM001548 PGS000680
(snpnet.Cystatin_C)
 PSS000681|
European Ancestry|
63,762 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Cystatin C [mg/L] — — R²: 0.29509
Spearman's ρ: 0.405		 Age, sex, PCs(1-40) —
PPM001591 PGS000680
(snpnet.Cystatin_C)
 PSS000802|
European Ancestry|
2,116 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Cystatin C [mg/L] — — Spearman's ρ: 0.255 Age, sex —
PPM007325 PGS000680
(snpnet.Cystatin_C)
 PSS007141|
African Ancestry|
6,098 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Cystatin C — — R²: 0.11726 [0.10257, 0.13195]
Incremental R2 (full-covars): 0.00628
PGS R2 (no covariates): 0.01457 [0.00879, 0.02036]		 age, sex, UKB array type, Genotype PCs —
PPM007326 PGS000680
(snpnet.Cystatin_C)
 PSS007142|
East Asian Ancestry|
1,617 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Cystatin C — — R²: 0.22897 [0.194, 0.26393]
Incremental R2 (full-covars): 0.02178
PGS R2 (no covariates): 0.03277 [0.01618, 0.04936]		 age, sex, UKB array type, Genotype PCs —
PPM007327 PGS000680
(snpnet.Cystatin_C)
 PSS007143|
European Ancestry|
23,779 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Cystatin C — — R²: 0.20012 [0.19124, 0.20901]
Incremental R2 (full-covars): 0.07378
PGS R2 (no covariates): 0.07907 [0.07263, 0.0855]		 age, sex, UKB array type, Genotype PCs —
PPM007328 PGS000680
(snpnet.Cystatin_C)
 PSS007144|
South Asian Ancestry|
7,426 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Cystatin C — — R²: 0.16627 [0.15122, 0.18132]
Incremental R2 (full-covars): 0.03349
PGS R2 (no covariates): 0.03448 [0.02654, 0.04242]		 age, sex, UKB array type, Genotype PCs —
PPM007329 PGS000680
(snpnet.Cystatin_C)
 PSS007145|
European Ancestry|
64,468 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Cystatin C — — R²: 0.21975 [0.21423, 0.22528]
Incremental R2 (full-covars): 0.09316
PGS R2 (no covariates): 0.09133 [0.08718, 0.09548]		 age, sex, UKB array type, Genotype PCs —
PPM010455 PGS001947
(portability-PLR_log_cystatinC)
 PSS008321|
South Asian Ancestry|
6,001 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C — — Partial Correlation (partial-r): 0.3057 [0.2826, 0.3285] sex, age, birth date, deprivation index, 16 PCs —
PPM010451 PGS001947
(portability-PLR_log_cystatinC)
 PSS009441|
European Ancestry|
18,996 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C — — Partial Correlation (partial-r): 0.418 [0.4062, 0.4297] sex, age, birth date, deprivation index, 16 PCs —
PPM010452 PGS001947
(portability-PLR_log_cystatinC)
 PSS009215|
European Ancestry|
3,953 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C — — Partial Correlation (partial-r): 0.4317 [0.4059, 0.4568] sex, age, birth date, deprivation index, 16 PCs —
PPM010454 PGS001947
(portability-PLR_log_cystatinC)
 PSS008543|
Greater Middle Eastern Ancestry|
1,126 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C — — Partial Correlation (partial-r): 0.3385 [0.2852, 0.3897] sex, age, birth date, deprivation index, 16 PCs —
PPM010457 PGS001947
(portability-PLR_log_cystatinC)
 PSS007885|
African Ancestry|
2,342 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C — — Partial Correlation (partial-r): 0.1917 [0.1522, 0.2306] sex, age, birth date, deprivation index, 16 PCs —
PPM010458 PGS001947
(portability-PLR_log_cystatinC)
 PSS008989|
African Ancestry|
3,658 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C — — Partial Correlation (partial-r): 0.1856 [0.1541, 0.2168] sex, age, birth date, deprivation index, 16 PCs —
PPM010453 PGS001947
(portability-PLR_log_cystatinC)
 PSS008769|
European Ancestry|
6,319 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C — — Partial Correlation (partial-r): 0.3864 [0.3652, 0.4072] sex, age, birth date, deprivation index, 16 PCs —
PPM010456 PGS001947
(portability-PLR_log_cystatinC)
 PSS008098|
East Asian Ancestry|
1,718 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C — — Partial Correlation (partial-r): 0.2689 [0.2242, 0.3125] sex, age, birth date, deprivation index, 16 PCs —
PPM012167 PGS002165
(portability-ldpred2_log_cystatinC)
 PSS009441|
European Ancestry|
18,996 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C — — Partial Correlation (partial-r): 0.4072 [0.3953, 0.419] sex, age, birth date, deprivation index, 16 PCs —
PPM012168 PGS002165
(portability-ldpred2_log_cystatinC)
 PSS009215|
European Ancestry|
3,953 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C — — Partial Correlation (partial-r): 0.4276 [0.4017, 0.4528] sex, age, birth date, deprivation index, 16 PCs —
PPM012169 PGS002165
(portability-ldpred2_log_cystatinC)
 PSS008769|
European Ancestry|
6,319 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C — — Partial Correlation (partial-r): 0.371 [0.3495, 0.3921] sex, age, birth date, deprivation index, 16 PCs —
PPM012170 PGS002165
(portability-ldpred2_log_cystatinC)
 PSS008543|
Greater Middle Eastern Ancestry|
1,126 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C — — Partial Correlation (partial-r): 0.3446 [0.2916, 0.3956] sex, age, birth date, deprivation index, 16 PCs —
PPM012171 PGS002165
(portability-ldpred2_log_cystatinC)
 PSS008321|
South Asian Ancestry|
6,001 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C — — Partial Correlation (partial-r): 0.3009 [0.2777, 0.3238] sex, age, birth date, deprivation index, 16 PCs —
PPM012173 PGS002165
(portability-ldpred2_log_cystatinC)
 PSS007885|
African Ancestry|
2,342 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C — — Partial Correlation (partial-r): 0.181 [0.1414, 0.2201] sex, age, birth date, deprivation index, 16 PCs —
PPM012174 PGS002165
(portability-ldpred2_log_cystatinC)
 PSS008989|
African Ancestry|
3,658 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C — — Partial Correlation (partial-r): 0.1653 [0.1335, 0.1967] sex, age, birth date, deprivation index, 16 PCs —
PPM012172 PGS002165
(portability-ldpred2_log_cystatinC)
 PSS008098|
East Asian Ancestry|
1,718 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C — — Partial Correlation (partial-r): 0.2565 [0.2115, 0.3004] sex, age, birth date, deprivation index, 16 PCs —
PPM015728 PGS003279
(ExPRSweb_CysC_30720-irnt_LASSOSUM_MGI_20211120)
 PSS010000|
Ancestry Not Reported|
213 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C β: -0.0115 (0.0535) — R²: 0.00174 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015731 PGS003280
(ExPRSweb_CysC_30720-irnt_PT_MGI_20211120)
 PSS010000|
Ancestry Not Reported|
213 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C β: -0.0229 (0.0513) — R²: 4e-05 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015729 PGS003281
(ExPRSweb_CysC_30720-irnt_PLINK_MGI_20211120)
 PSS010000|
Ancestry Not Reported|
213 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C β: -0.0217 (0.0481) — R²: 7.56e-07 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015727 PGS003282
(ExPRSweb_CysC_30720-irnt_DBSLMM_MGI_20211120)
 PSS010000|
Ancestry Not Reported|
213 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C β: -0.0119 (0.0509) — R²: 0.00026 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015730 PGS003283
(ExPRSweb_CysC_30720-irnt_PRSCS_MGI_20211120)
 PSS010000|
Ancestry Not Reported|
213 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C β: -0.00096 (0.0523) — R²: 0.00308 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015733 PGS003284
(ExPRSweb_CysC_30720-raw_LASSOSUM_MGI_20211120)
 PSS010000|
Ancestry Not Reported|
213 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C β: -0.0222 (0.0552) — R²: 0.00215 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015736 PGS003285
(ExPRSweb_CysC_30720-raw_PT_MGI_20211120)
 PSS010000|
Ancestry Not Reported|
213 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C β: -0.0277 (0.049) — R²: 6.50e-07 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015734 PGS003286
(ExPRSweb_CysC_30720-raw_PLINK_MGI_20211120)
 PSS010000|
Ancestry Not Reported|
213 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C β: -0.0177 (0.0484) — R²: 0.00011 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015732 PGS003287
(ExPRSweb_CysC_30720-raw_DBSLMM_MGI_20211120)
 PSS010000|
Ancestry Not Reported|
213 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C β: -0.0205 (0.051) — R²: 4e-05 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015735 PGS003288
(ExPRSweb_CysC_30720-raw_PRSCS_MGI_20211120)
 PSS010000|
Ancestry Not Reported|
213 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C β: 0.0125 (0.0558) — R²: 0.00245 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015739 PGS003289
(ExPRSweb_CysC_CKDGen-1000Genomes-DiscoveryMeta-eGFRcys_LASSOSUM_MGI_20211120)
 PSS010020|
European Ancestry|
19,504 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: eGFR β: -0.0524 (0.0525) — R²: 0.00038 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015745 PGS003290
(ExPRSweb_CysC_CKDGen-1000Genomes-DiscoveryMeta-eGFRcys_PT_MGI_20211120)
 PSS010020|
European Ancestry|
19,504 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: eGFR β: -0.0298 (0.0525) — R²: 2e-05 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015741 PGS003291
(ExPRSweb_CysC_CKDGen-1000Genomes-DiscoveryMeta-eGFRcys_PLINK_MGI_20211120)
 PSS010020|
European Ancestry|
19,504 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: eGFR β: -0.0339 (0.0521) — R²: 0.0001 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015737 PGS003292
(ExPRSweb_CysC_CKDGen-1000Genomes-DiscoveryMeta-eGFRcys_DBSLMM_MGI_20211120)
 PSS010020|
European Ancestry|
19,504 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: eGFR β: 0.0339 (0.0485) — R²: 0.00258 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015743 PGS003293
(ExPRSweb_CysC_CKDGen-1000Genomes-DiscoveryMeta-eGFRcys_PRSCS_MGI_20211120)
 PSS010020|
European Ancestry|
19,504 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: eGFR β: 0.00954 (0.0537) — R²: 0.0131 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015749 PGS003294
(ExPRSweb_CysC_eGFRcys-overall-EA_LASSOSUM_MGI_20211120)
 PSS010020|
European Ancestry|
19,504 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: eGFR β: -0.0131 (0.0552) — R²: 0.00398 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015755 PGS003295
(ExPRSweb_CysC_eGFRcys-overall-EA_PT_MGI_20211120)
 PSS010020|
European Ancestry|
19,504 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: eGFR β: 0.0475 (0.0562) — R²: 0.00743 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015751 PGS003296
(ExPRSweb_CysC_eGFRcys-overall-EA_PLINK_MGI_20211120)
 PSS010020|
European Ancestry|
19,504 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: eGFR β: -0.0261 (0.0529) — R²: 3e-05 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015747 PGS003297
(ExPRSweb_CysC_eGFRcys-overall-EA_DBSLMM_MGI_20211120)
 PSS010020|
European Ancestry|
19,504 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: eGFR β: -0.0371 (0.0545) — R²: 0.00926 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015753 PGS003298
(ExPRSweb_CysC_eGFRcys-overall-EA_PRSCS_MGI_20211120)
 PSS010020|
European Ancestry|
19,504 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: eGFR β: 0.0457 (0.049) — R²: 0.0103 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015759 PGS003299
(ExPRSweb_CysC_eGFRcys-overall-IV-2GC_LASSOSUM_MGI_20211120)
 PSS010020|
European Ancestry|
19,504 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: eGFR β: -0.021 (0.0515) — R²: 0.015 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015765 PGS003300
(ExPRSweb_CysC_eGFRcys-overall-IV-2GC_PT_MGI_20211120)
 PSS010020|
European Ancestry|
19,504 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: eGFR β: 0.0484 (0.0519) — R²: 0.00015 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015761 PGS003301
(ExPRSweb_CysC_eGFRcys-overall-IV-2GC_PLINK_MGI_20211120)
 PSS010020|
European Ancestry|
19,504 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: eGFR β: 0.0486 (0.0519) — R²: 7e-05 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015757 PGS003302
(ExPRSweb_CysC_eGFRcys-overall-IV-2GC_DBSLMM_MGI_20211120)
 PSS010020|
European Ancestry|
19,504 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: eGFR β: 0.0163 (0.0472) — R²: 0.00069 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015763 PGS003303
(ExPRSweb_CysC_eGFRcys-overall-IV-2GC_PRSCS_MGI_20211120)
 PSS010020|
European Ancestry|
19,504 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: eGFR β: -0.0446 (0.0567) — R²: 0.0349 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015740 PGS003304
(ExPRSweb_CysC_CKDGen-1000Genomes-DiscoveryMeta-eGFRcys_LASSOSUM_UKB_20211120)
 PSS010026|
European Ancestry|
390,221 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C β: 0.0328 (0.000358) — R²: 0.0356 Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 —
PPM015746 PGS003305
(ExPRSweb_CysC_CKDGen-1000Genomes-DiscoveryMeta-eGFRcys_PT_UKB_20211120)
 PSS010026|
European Ancestry|
390,221 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C β: 0.0314 (0.000359) — R²: 0.0326 Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 —
PPM015742 PGS003306
(ExPRSweb_CysC_CKDGen-1000Genomes-DiscoveryMeta-eGFRcys_PLINK_UKB_20211120)
 PSS010026|
European Ancestry|
390,221 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C β: 0.0314 (0.000359) — R²: 0.0326 Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 —
PPM015738 PGS003307
(ExPRSweb_CysC_CKDGen-1000Genomes-DiscoveryMeta-eGFRcys_DBSLMM_UKB_20211120)
 PSS010026|
European Ancestry|
390,221 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C β: -0.00171 (0.000365) — R²: 0.0001 Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 —
PPM015744 PGS003308
(ExPRSweb_CysC_CKDGen-1000Genomes-DiscoveryMeta-eGFRcys_PRSCS_UKB_20211120)
 PSS010026|
European Ancestry|
390,221 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C β: 0.0275 (0.00036) — R²: 0.0251 Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 —
PPM015750 PGS003309
(ExPRSweb_CysC_eGFRcys-overall-EA_LASSOSUM_UKB_20211120)
 PSS010026|
European Ancestry|
390,221 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C β: -0.0311 (0.000352) — R²: 0.0335 Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 —
PPM015756 PGS003310
(ExPRSweb_CysC_eGFRcys-overall-EA_PT_UKB_20211120)
 PSS010026|
European Ancestry|
390,221 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C β: -0.0294 (0.000353) — R²: 0.03 Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 —
PPM015752 PGS003311
(ExPRSweb_CysC_eGFRcys-overall-EA_PLINK_UKB_20211120)
 PSS010026|
European Ancestry|
390,221 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C β: -0.0297 (0.000353) — R²: 0.0304 Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 —
PPM015748 PGS003312
(ExPRSweb_CysC_eGFRcys-overall-EA_DBSLMM_UKB_20211120)
 PSS010026|
European Ancestry|
390,221 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C β: -0.0285 (0.000353) — R²: 0.0282 Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 —
PPM015754 PGS003313
(ExPRSweb_CysC_eGFRcys-overall-EA_PRSCS_UKB_20211120)
 PSS010026|
European Ancestry|
390,221 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C β: -0.0101 (0.000359) — R²: 0.00374 Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 —
PPM015760 PGS003314
(ExPRSweb_CysC_eGFRcys-overall-IV-2GC_LASSOSUM_UKB_20211120)
 PSS010026|
European Ancestry|
390,221 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C β: -0.0329 (0.000351) — R²: 0.0375 Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 —
PPM015766 PGS003315
(ExPRSweb_CysC_eGFRcys-overall-IV-2GC_PT_UKB_20211120)
 PSS010026|
European Ancestry|
390,221 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C β: -0.0312 (0.000352) — R²: 0.0336 Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 —
PPM015762 PGS003316
(ExPRSweb_CysC_eGFRcys-overall-IV-2GC_PLINK_UKB_20211120)
 PSS010026|
European Ancestry|
390,221 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C β: -0.0312 (0.000352) — R²: 0.0336 Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 —
PPM015758 PGS003317
(ExPRSweb_CysC_eGFRcys-overall-IV-2GC_DBSLMM_UKB_20211120)
 PSS010026|
European Ancestry|
390,221 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C β: -0.0155 (0.000358) — R²: 0.0084 Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 —
PPM015764 PGS003318
(ExPRSweb_CysC_eGFRcys-overall-IV-2GC_PRSCS_UKB_20211120)
 PSS010026|
European Ancestry|
390,221 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Cystatin C β: -0.0272 (0.000354) — R²: 0.0255 Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 —
PPM017456 PGS003528
(cont-decay-log_cystatinC)
 PSS010891|
European Ancestry|
19,120 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Cystatin C — — partial-R2: 0.16 sex, age, deprivation index, PC1-16 —
PPM017540 PGS003528
(cont-decay-log_cystatinC)
 PSS010807|
European Ancestry|
3,942 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Cystatin C — — partial-R2: 0.18 sex, age, deprivation index, PC1-16 —
PPM017624 PGS003528
(cont-decay-log_cystatinC)
 PSS010639|
European Ancestry|
6,167 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Cystatin C — — partial-R2: 0.14 sex, age, deprivation index, PC1-16 —
PPM017708 PGS003528
(cont-decay-log_cystatinC)
 PSS010555|
Greater Middle Eastern Ancestry|
1,097 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Cystatin C — — partial-R2: 0.12 sex, age, deprivation index, PC1-16 —
PPM017792 PGS003528
(cont-decay-log_cystatinC)
 PSS010219|
European Ancestry|
2,236 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Cystatin C — — partial-R2: 0.12 sex, age, deprivation index, PC1-16 —
PPM017876 PGS003528
(cont-decay-log_cystatinC)
 PSS010471|
South Asian Ancestry|
5,948 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Cystatin C — — partial-R2: 0.09 sex, age, deprivation index, PC1-16 —
PPM017960 PGS003528
(cont-decay-log_cystatinC)
 PSS010387|
East Asian Ancestry|
1,707 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Cystatin C — — partial-R2: 0.06 sex, age, deprivation index, PC1-16 —
PPM018044 PGS003528
(cont-decay-log_cystatinC)
 PSS010303|
African Ancestry|
2,330 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Cystatin C — — partial-R2: 0.03 sex, age, deprivation index, PC1-16 —
PPM018128 PGS003528
(cont-decay-log_cystatinC)
 PSS010723|
African Ancestry|
3,629 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Cystatin C — — partial-R2: 0.03 sex, age, deprivation index, PC1-16 —
PPM018283 PGS003589
(UKB_cycproduction_EUR)
 PSS010957|
European Ancestry|
50,000 individuals
 PGP000463 |
Kleeman SO et al. Cell Genom (2023)
 Reported Trait: Cystatin C production — — R²: 0.08 Age, sex, PC1-4, recruitment center, genotyping array —
PPM018284 PGS003590
(UKB_cycproduction_EUR_exome)
 PSS010957|
European Ancestry|
50,000 individuals
 PGP000463 |
Kleeman SO et al. Cell Genom (2023)
 Reported Trait: Cystatin C production — — R²: 0.04 Age, sex, PC1-4, recruitment center, genotyping array —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000679 — — 23,580 individuals — European Non-British White UKB —
PSS000680 — — 7,338 individuals — South Asian — UKB —
PSS000681 — — 63,762 individuals — European
(British)		 — UKB —
PSS007885 — — 2,342 individuals — African American or Afro-Caribbean Carribean UKB —
PSS010807 — — 3,942 individuals,
38.0 % Male samples
 Mean = 54.4 years
Sd = 7.5 years		 European Polish UKB —
PSS008543 — — 1,126 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009441 — — 18,996 individuals — European UK (+ Ireland) UKB —
PSS010555 — — 1,097 individuals,
60.0 % Male samples
 Mean = 51.9 years
Sd = 8.0 years		 Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB —
PSS010303 — — 2,330 individuals,
37.0 % Male samples
 Mean = 52.5 years
Sd = 8.1 years		 African American or Afro-Caribbean Caribbean UKB —
PSS007141 — — 6,098 individuals — African unspecified — UKB —
PSS007142 — — 1,617 individuals — East Asian — UKB —
PSS007143 — — 23,779 individuals — European non-white British ancestry UKB —
PSS007144 — — 7,426 individuals — South Asian — UKB —
PSS007145 — — 64,468 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS010000 — — 213 individuals — Not reported — MGI —
PSS009215 — — 3,953 individuals — European Poland (NE Europe) UKB —
PSS008321 — — 6,001 individuals — South Asian India (South Asia) UKB —
PSS010020 Estimated GFR, Non-Black (LOINC: 48642-3); Quantitative — 19,504 individuals — European — MGI —
PSS010723 — — 3,629 individuals,
46.0 % Male samples
 Mean = 51.9 years
Sd = 8.1 years		 African unspecified Nigerian UKB —
PSS010471 — — 5,948 individuals,
54.0 % Male samples
 Mean = 53.3 years
Sd = 8.4 years		 South Asian Indian UKB —
PSS010957 — — 50,000 individuals — European — UKB —
PSS010026 Field ID: 30720; Quantitative — 195,103 individuals — European — UKB —
PSS010026 Field ID: 30720; Quantitative — 195,118 individuals — European — UKB —
PSS010219 — — 2,236 individuals,
45.0 % Male samples
 Mean = 58.1 years
Sd = 7.1 years		 European Ashkenazi UKB —
PSS008989 — — 3,658 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008098 — — 1,718 individuals — East Asian China (East Asia) UKB —
PSS010891 — — 19,120 individuals,
46.0 % Male samples
 Mean = 56.9 years
Sd = 7.9 years		 European white British UKB —
PSS010639 — — 6,167 individuals,
45.0 % Male samples
 Mean = 54.5 years
Sd = 8.4 years		 European Italian UKB —
PSS010387 — — 1,707 individuals,
33.0 % Male samples
 Mean = 52.4 years
Sd = 7.8 years		 East Asian Chinese UKB —
PSS000802 — — 2,116 individuals — European Participants self-identifying as white MESA —
PSS008769 — — 6,319 individuals — European Italy (South Europe) UKB —
PSS000677 — — 6,015 individuals — African unspecified — UKB —
PSS000678 — — 1,082 individuals — East Asian — UKB —