Trait: intraocular pressure measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004695
  • Is a quantification of intraocular pressure. Increased intraocular pressure is a heritable risk factor for primary open angle glaucoma.
Trait category
Other measurement

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000124 IOP_AS PGP000061 MacGregor S et al. Nat Genet (2018) Intraocular pressure intraocular pressure measurement 103

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
Evaluated Score PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000403 PGS000124
PSS000231 PGP000061 MacGregor S et al. (2018) Reported Trait: Advanced glaucoma AUROC: 0.65 [0.63, 0.66] sex, first 4 genetic PCs

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000231 Advanced primary open-angle glaucoma
  • 1,734 cases
  • , 2,938 controls
European ANZRAG Samples come from Phase 1 and Phase 2 of ANZRAG.