Trait: sex hormone-binding globulin measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004696
Description
  • Is a quantification of sex hormone binding globulin. In men the test is used in when investigating testosterone deficiency. The SHBG glycoprotein binds to circulating estradiol and testosterone, low levels of SHBG may be implicated in breast cancer etiology.
Trait category
Other measurement
Synonyms 2 synonyms
  • SHBG level
  • SHBG levels

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000694 snpnet.SHBG PGP000128 Sinnott-Armstrong N et al. Nat Genet (2021) SHBG [nmol/L] sex hormone-binding globulin measurement 19,328 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000694/ScoringFiles/PGS000694.txt.gz - Check Terms/Licenses

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID) 		Evaluated Score PGS Sample Set ID
(PSS ID) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001422 PGS000694
(snpnet.SHBG)
 PSS000744 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: SHBG [nmol/L] — — R²: 0.22708
Spearman's ρ: 0.235		 Age, sex, PCs(1-40) —
PPM001457 PGS000694
(snpnet.SHBG)
 PSS000745 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: SHBG [nmol/L] — — R²: 0.31846
Spearman's ρ: 0.311		 Age, sex, PCs(1-40) —
PPM001492 PGS000694
(snpnet.SHBG)
 PSS000746 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: SHBG [nmol/L] — — R²: 0.35511
Spearman's ρ: 0.384		 Age, sex, PCs(1-40) —
PPM001527 PGS000694
(snpnet.SHBG)
 PSS000747 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: SHBG [nmol/L] — — R²: 0.28079
Spearman's ρ: 0.326		 Age, sex, PCs(1-40) —
PPM001562 PGS000694
(snpnet.SHBG)
 PSS000748 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: SHBG [nmol/L] — — R²: 0.34576
Spearman's ρ: 0.414		 Age, sex, PCs(1-40) —
PPM001571 PGS000694
(snpnet.SHBG)
 PSS000830 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: SHBG [nmol/L] — — Spearman's ρ: 0.19 Age, sex —

Evaluated Samples

PGS Sample Set ID
(PSS ID) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000744 — — 5,523 individuals — African unspecified — UKB —
PSS000745 — — 979 individuals — East Asian — UKB —
PSS000746 — — 21,313 individuals — European Non-British White UKB —
PSS000747 — — 6,638 individuals — South Asian — UKB —
PSS000748 — — 57,677 individuals — European
(British)		 — UKB —
PSS000830 — — 2,129 individuals — European Participants self-identifying as white MESA —