Trait: sex hormone-binding globulin measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004696
Description Is a quantification of sex hormone binding globulin. In men the test is used in when investigating testosterone deficiency. The SHBG glycoprotein binds to circulating estradiol and testosterone, low levels of SHBG may be implicated in breast cancer etiology.
Trait category
Other measurement
Synonyms 2 synonyms
  • SHBG level
  • SHBG levels
Mapped term uniprot:P04278

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000694
(snpnet.SHBG)
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 SHBG [nmol/L] sex hormone-binding globulin measurement 19,328
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000694/ScoringFiles/PGS000694.txt.gz - Check Terms/Licenses
PGS001977
(portability-PLR_log_SHBG)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Sex hormone binding globulin (SHBG) sex hormone-binding globulin measurement 51,427
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001977/ScoringFiles/PGS001977.txt.gz
PGS002195
(portability-ldpred2_log_SHBG)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Sex hormone binding globulin (SHBG) sex hormone-binding globulin measurement 650,364
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002195/ScoringFiles/PGS002195.txt.gz
PGS003552
(cont-decay-log_SHBG)
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Sex hormone binding globulin (SHBG) sex hormone-binding globulin measurement 979,739
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003552/ScoringFiles/PGS003552.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001422 PGS000694
(snpnet.SHBG)
 PSS000744|
African Ancestry|
5,523 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: SHBG [nmol/L] — — R²: 0.22708
Spearman's ρ: 0.235		 Age, sex, PCs(1-40) —
PPM001457 PGS000694
(snpnet.SHBG)
 PSS000745|
East Asian Ancestry|
979 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: SHBG [nmol/L] — — R²: 0.31846
Spearman's ρ: 0.311		 Age, sex, PCs(1-40) —
PPM001492 PGS000694
(snpnet.SHBG)
 PSS000746|
European Ancestry|
21,313 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: SHBG [nmol/L] — — R²: 0.35511
Spearman's ρ: 0.384		 Age, sex, PCs(1-40) —
PPM001527 PGS000694
(snpnet.SHBG)
 PSS000747|
South Asian Ancestry|
6,638 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: SHBG [nmol/L] — — R²: 0.28079
Spearman's ρ: 0.326		 Age, sex, PCs(1-40) —
PPM001562 PGS000694
(snpnet.SHBG)
 PSS000748|
European Ancestry|
57,677 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: SHBG [nmol/L] — — R²: 0.34576
Spearman's ρ: 0.414		 Age, sex, PCs(1-40) —
PPM001571 PGS000694
(snpnet.SHBG)
 PSS000830|
European Ancestry|
2,129 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: SHBG [nmol/L] — — Spearman's ρ: 0.19 Age, sex —
PPM007395 PGS000694
(snpnet.SHBG)
 PSS007186|
African Ancestry|
5,606 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: SHBG — — R²: 0.15136 [0.13531, 0.16741]
Incremental R2 (full-covars): 0.00248
PGS R2 (no covariates): 0.04048 [0.0311, 0.04987]		 age, sex, UKB array type, Genotype PCs —
PPM007396 PGS000694
(snpnet.SHBG)
 PSS007187|
East Asian Ancestry|
1,463 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: SHBG — — R²: 0.21699 [0.18242, 0.25155]
Incremental R2 (full-covars): 0.00252
PGS R2 (no covariates): 0.04369 [0.02475, 0.06264]		 age, sex, UKB array type, Genotype PCs —
PPM007397 PGS000694
(snpnet.SHBG)
 PSS007188|
European Ancestry|
21,531 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: SHBG — — R²: 0.18855 [0.1798, 0.1973]
Incremental R2 (full-covars): 0.00395
PGS R2 (no covariates): 0.09661 [0.08964, 0.10359]		 age, sex, UKB array type, Genotype PCs —
PPM007398 PGS000694
(snpnet.SHBG)
 PSS007189|
South Asian Ancestry|
6,736 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: SHBG — — R²: 0.13468 [0.12062, 0.14874]
Incremental R2 (full-covars): 0.004
PGS R2 (no covariates): 0.07268 [0.06161, 0.08375]		 age, sex, UKB array type, Genotype PCs —
PPM007399 PGS000694
(snpnet.SHBG)
 PSS007190|
European Ancestry|
58,525 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: SHBG — — R²: 0.16541 [0.16028, 0.17053]
Incremental R2 (full-covars): 0.0045
PGS R2 (no covariates): 0.11086 [0.10639, 0.11533]		 age, sex, UKB array type, Genotype PCs —
PPM022571 PGS000694
(snpnet.SHBG)
 PSS012020|
European Ancestry|
233 individuals
 PGP000725 |
Busch AS et al. J Clin Endocrinol Metab (2024)
|Ext.		 Reported Trait: Mean SHBG SDS in infancy β: 2.4 (0.5) — R²: 0.18 — —
PPM010692 PGS001977
(portability-PLR_log_SHBG)
 PSS009210|
European Ancestry|
3,563 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sex hormone binding globulin (SHBG) — — Partial Correlation (partial-r): 0.3909 [0.3627, 0.4185] sex, age, birth date, deprivation index, 16 PCs —
PPM010693 PGS001977
(portability-PLR_log_SHBG)
 PSS008764|
European Ancestry|
5,738 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sex hormone binding globulin (SHBG) — — Partial Correlation (partial-r): 0.4056 [0.3837, 0.427] sex, age, birth date, deprivation index, 16 PCs —
PPM010694 PGS001977
(portability-PLR_log_SHBG)
 PSS008538|
Greater Middle Eastern Ancestry|
1,025 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sex hormone binding globulin (SHBG) — — Partial Correlation (partial-r): 0.3846 [0.3307, 0.4361] sex, age, birth date, deprivation index, 16 PCs —
PPM010695 PGS001977
(portability-PLR_log_SHBG)
 PSS008316|
South Asian Ancestry|
5,437 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sex hormone binding globulin (SHBG) — — Partial Correlation (partial-r): 0.3532 [0.3297, 0.3763] sex, age, birth date, deprivation index, 16 PCs —
PPM010696 PGS001977
(portability-PLR_log_SHBG)
 PSS008093|
East Asian Ancestry|
1,548 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sex hormone binding globulin (SHBG) — — Partial Correlation (partial-r): 0.3607 [0.3163, 0.4035] sex, age, birth date, deprivation index, 16 PCs —
PPM010697 PGS001977
(portability-PLR_log_SHBG)
 PSS007880|
African Ancestry|
2,140 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sex hormone binding globulin (SHBG) — — Partial Correlation (partial-r): 0.2192 [0.1783, 0.2594] sex, age, birth date, deprivation index, 16 PCs —
PPM010698 PGS001977
(portability-PLR_log_SHBG)
 PSS008984|
African Ancestry|
3,374 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sex hormone binding globulin (SHBG) — — Partial Correlation (partial-r): 0.1912 [0.1584, 0.2236] sex, age, birth date, deprivation index, 16 PCs —
PPM010691 PGS001977
(portability-PLR_log_SHBG)
 PSS009436|
European Ancestry|
17,266 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sex hormone binding globulin (SHBG) — — Partial Correlation (partial-r): 0.4274 [0.4152, 0.4396] sex, age, birth date, deprivation index, 16 PCs —
PPM012407 PGS002195
(portability-ldpred2_log_SHBG)
 PSS009436|
European Ancestry|
17,266 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sex hormone binding globulin (SHBG) — — Partial Correlation (partial-r): 0.417 [0.4046, 0.4292] sex, age, birth date, deprivation index, 16 PCs —
PPM012408 PGS002195
(portability-ldpred2_log_SHBG)
 PSS009210|
European Ancestry|
3,563 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sex hormone binding globulin (SHBG) — — Partial Correlation (partial-r): 0.3776 [0.349, 0.4055] sex, age, birth date, deprivation index, 16 PCs —
PPM012410 PGS002195
(portability-ldpred2_log_SHBG)
 PSS008538|
Greater Middle Eastern Ancestry|
1,025 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sex hormone binding globulin (SHBG) — — Partial Correlation (partial-r): 0.3852 [0.3312, 0.4366] sex, age, birth date, deprivation index, 16 PCs —
PPM012411 PGS002195
(portability-ldpred2_log_SHBG)
 PSS008316|
South Asian Ancestry|
5,437 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sex hormone binding globulin (SHBG) — — Partial Correlation (partial-r): 0.3497 [0.3261, 0.3729] sex, age, birth date, deprivation index, 16 PCs —
PPM012412 PGS002195
(portability-ldpred2_log_SHBG)
 PSS008093|
East Asian Ancestry|
1,548 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sex hormone binding globulin (SHBG) — — Partial Correlation (partial-r): 0.3684 [0.3242, 0.4109] sex, age, birth date, deprivation index, 16 PCs —
PPM012413 PGS002195
(portability-ldpred2_log_SHBG)
 PSS007880|
African Ancestry|
2,140 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sex hormone binding globulin (SHBG) — — Partial Correlation (partial-r): 0.2151 [0.1741, 0.2554] sex, age, birth date, deprivation index, 16 PCs —
PPM012414 PGS002195
(portability-ldpred2_log_SHBG)
 PSS008984|
African Ancestry|
3,374 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sex hormone binding globulin (SHBG) — — Partial Correlation (partial-r): 0.1604 [0.1272, 0.1932] sex, age, birth date, deprivation index, 16 PCs —
PPM012409 PGS002195
(portability-ldpred2_log_SHBG)
 PSS008764|
European Ancestry|
5,738 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sex hormone binding globulin (SHBG) — — Partial Correlation (partial-r): 0.3934 [0.3713, 0.4151] sex, age, birth date, deprivation index, 16 PCs —
PPM017480 PGS003552
(cont-decay-log_SHBG)
 PSS010918|
European Ancestry|
17,359 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Sex hormone binding globulin (SHBG) — — partial-R2: 0.18 sex, age, deprivation index, PC1-16 —
PPM017648 PGS003552
(cont-decay-log_SHBG)
 PSS010666|
European Ancestry|
5,599 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Sex hormone binding globulin (SHBG) — — partial-R2: 0.15 sex, age, deprivation index, PC1-16 —
PPM017732 PGS003552
(cont-decay-log_SHBG)
 PSS010582|
Greater Middle Eastern Ancestry|
996 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Sex hormone binding globulin (SHBG) — — partial-R2: 0.13 sex, age, deprivation index, PC1-16 —
PPM017816 PGS003552
(cont-decay-log_SHBG)
 PSS010246|
European Ancestry|
2,029 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Sex hormone binding globulin (SHBG) — — partial-R2: 0.15 sex, age, deprivation index, PC1-16 —
PPM017900 PGS003552
(cont-decay-log_SHBG)
 PSS010498|
South Asian Ancestry|
5,386 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Sex hormone binding globulin (SHBG) — — partial-R2: 0.12 sex, age, deprivation index, PC1-16 —
PPM017984 PGS003552
(cont-decay-log_SHBG)
 PSS010414|
East Asian Ancestry|
1,538 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Sex hormone binding globulin (SHBG) — — partial-R2: 0.12 sex, age, deprivation index, PC1-16 —
PPM018068 PGS003552
(cont-decay-log_SHBG)
 PSS010330|
African Ancestry|
2,129 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Sex hormone binding globulin (SHBG) — — partial-R2: 0.04 sex, age, deprivation index, PC1-16 —
PPM018152 PGS003552
(cont-decay-log_SHBG)
 PSS010750|
African Ancestry|
3,347 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Sex hormone binding globulin (SHBG) — — partial-R2: 0.03 sex, age, deprivation index, PC1-16 —
PPM017564 PGS003552
(cont-decay-log_SHBG)
 PSS010834|
European Ancestry|
3,551 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Sex hormone binding globulin (SHBG) — — partial-R2: 0.14 sex, age, deprivation index, PC1-16 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007880 — — 2,140 individuals — African American or Afro-Caribbean Carribean UKB —
PSS010918 — — 17,359 individuals,
47.0 % Male samples
 Mean = 56.9 years
Sd = 7.9 years		 European white British UKB —
PSS010666 — — 5,599 individuals,
46.0 % Male samples
 Mean = 54.5 years
Sd = 8.4 years		 European Italian UKB —
PSS010414 — — 1,538 individuals,
33.0 % Male samples
 Mean = 52.5 years
Sd = 7.8 years		 East Asian Chinese UKB —
PSS008538 — — 1,025 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS000830 — — 2,129 individuals — European Participants self-identifying as white MESA —
PSS009436 — — 17,266 individuals — European UK (+ Ireland) UKB —
PSS010834 — — 3,551 individuals,
39.0 % Male samples
 Mean = 54.4 years
Sd = 7.5 years		 European Polish UKB —
PSS009210 — — 3,563 individuals — European Poland (NE Europe) UKB —
PSS008316 — — 5,437 individuals — South Asian India (South Asia) UKB —
PSS010582 — — 996 individuals,
60.0 % Male samples
 Mean = 51.9 years
Sd = 7.9 years		 Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB —
PSS010330 — — 2,129 individuals,
37.0 % Male samples
 Mean = 52.5 years
Sd = 8.1 years		 African American or Afro-Caribbean Caribbean UKB —
PSS012020 mean age-specific serum concentrations, i.e., SDS, of reproductive hormone concentrations based on the respective reference curves — 233 individuals,
100.0 % Male samples
 — European — NR —
PSS000744 — — 5,523 individuals — African unspecified — UKB —
PSS000745 — — 979 individuals — East Asian — UKB —
PSS000746 — — 21,313 individuals — European Non-British White UKB —
PSS000747 — — 6,638 individuals — South Asian — UKB —
PSS000748 — — 57,677 individuals — European
(British)		 — UKB —
PSS008984 — — 3,374 individuals — African unspecified Nigeria (West Africa) UKB —
PSS007186 — — 5,606 individuals — African unspecified — UKB —
PSS007187 — — 1,463 individuals — East Asian — UKB —
PSS007188 — — 21,531 individuals — European non-white British ancestry UKB —
PSS008093 — — 1,548 individuals — East Asian China (East Asia) UKB —
PSS007189 — — 6,736 individuals — South Asian — UKB —
PSS007190 — — 58,525 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS010750 — — 3,347 individuals,
47.0 % Male samples
 Mean = 51.9 years
Sd = 8.1 years		 African unspecified Nigerian UKB —
PSS010498 — — 5,386 individuals,
55.0 % Male samples
 Mean = 53.2 years
Sd = 8.4 years		 South Asian Indian UKB —
PSS010246 — — 2,029 individuals,
46.0 % Male samples
 Mean = 58.1 years
Sd = 7.0 years		 European Ashkenazi UKB —
PSS008764 — — 5,738 individuals — European Italy (South Europe) UKB —