Trait: sex hormone-binding globulin measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004696
Description Is a quantification of sex hormone binding globulin. In men the test is used in when investigating testosterone deficiency. The SHBG glycoprotein binds to circulating estradiol and testosterone, low levels of SHBG may be implicated in breast cancer etiology.
Trait category
Other measurement
Synonyms 2 synonyms
  • SHBG level
  • SHBG levels

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS000694
(snpnet.SHBG)
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
SHBG [nmol/L] sex hormone-binding globulin measurement 19,328
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000694/ScoringFiles/PGS000694.txt.gz - Check Terms/Licenses
PGS001977
(portability-PLR_log_SHBG)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Sex hormone binding globulin (SHBG) sex hormone-binding globulin measurement 51,427
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001977/ScoringFiles/PGS001977.txt.gz
PGS002195
(portability-ldpred2_log_SHBG)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Sex hormone binding globulin (SHBG) sex hormone-binding globulin measurement 650,364
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002195/ScoringFiles/PGS002195.txt.gz
PGS003552
(cont-decay-log_SHBG)
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Sex hormone binding globulin (SHBG) sex hormone-binding globulin measurement 979,739
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003552/ScoringFiles/PGS003552.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001422 PGS000694
(snpnet.SHBG)
PSS000744|
African Ancestry|
5,523 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: SHBG [nmol/L] : 0.22708
Spearman's ρ: 0.235
Age, sex, PCs(1-40)
PPM001457 PGS000694
(snpnet.SHBG)
PSS000745|
East Asian Ancestry|
979 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: SHBG [nmol/L] : 0.31846
Spearman's ρ: 0.311
Age, sex, PCs(1-40)
PPM001492 PGS000694
(snpnet.SHBG)
PSS000746|
European Ancestry|
21,313 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: SHBG [nmol/L] : 0.35511
Spearman's ρ: 0.384
Age, sex, PCs(1-40)
PPM001527 PGS000694
(snpnet.SHBG)
PSS000747|
South Asian Ancestry|
6,638 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: SHBG [nmol/L] : 0.28079
Spearman's ρ: 0.326
Age, sex, PCs(1-40)
PPM001562 PGS000694
(snpnet.SHBG)
PSS000748|
European Ancestry|
57,677 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: SHBG [nmol/L] : 0.34576
Spearman's ρ: 0.414
Age, sex, PCs(1-40)
PPM001571 PGS000694
(snpnet.SHBG)
PSS000830|
European Ancestry|
2,129 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: SHBG [nmol/L] Spearman's ρ: 0.19 Age, sex
PPM007395 PGS000694
(snpnet.SHBG)
PSS007186|
African Ancestry|
5,606 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: SHBG : 0.15136 [0.13531, 0.16741]
Incremental R2 (full-covars): 0.00248
PGS R2 (no covariates): 0.04048 [0.0311, 0.04987]
age, sex, UKB array type, Genotype PCs
PPM007396 PGS000694
(snpnet.SHBG)
PSS007187|
East Asian Ancestry|
1,463 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: SHBG : 0.21699 [0.18242, 0.25155]
Incremental R2 (full-covars): 0.00252
PGS R2 (no covariates): 0.04369 [0.02475, 0.06264]
age, sex, UKB array type, Genotype PCs
PPM007397 PGS000694
(snpnet.SHBG)
PSS007188|
European Ancestry|
21,531 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: SHBG : 0.18855 [0.1798, 0.1973]
Incremental R2 (full-covars): 0.00395
PGS R2 (no covariates): 0.09661 [0.08964, 0.10359]
age, sex, UKB array type, Genotype PCs
PPM007398 PGS000694
(snpnet.SHBG)
PSS007189|
South Asian Ancestry|
6,736 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: SHBG : 0.13468 [0.12062, 0.14874]
Incremental R2 (full-covars): 0.004
PGS R2 (no covariates): 0.07268 [0.06161, 0.08375]
age, sex, UKB array type, Genotype PCs
PPM007399 PGS000694
(snpnet.SHBG)
PSS007190|
European Ancestry|
58,525 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: SHBG : 0.16541 [0.16028, 0.17053]
Incremental R2 (full-covars): 0.0045
PGS R2 (no covariates): 0.11086 [0.10639, 0.11533]
age, sex, UKB array type, Genotype PCs
PPM010692 PGS001977
(portability-PLR_log_SHBG)
PSS009210|
European Ancestry|
3,563 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sex hormone binding globulin (SHBG) Partial Correlation (partial-r): 0.3909 [0.3627, 0.4185] sex, age, birth date, deprivation index, 16 PCs
PPM010693 PGS001977
(portability-PLR_log_SHBG)
PSS008764|
European Ancestry|
5,738 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sex hormone binding globulin (SHBG) Partial Correlation (partial-r): 0.4056 [0.3837, 0.427] sex, age, birth date, deprivation index, 16 PCs
PPM010694 PGS001977
(portability-PLR_log_SHBG)
PSS008538|
Greater Middle Eastern Ancestry|
1,025 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sex hormone binding globulin (SHBG) Partial Correlation (partial-r): 0.3846 [0.3307, 0.4361] sex, age, birth date, deprivation index, 16 PCs
PPM010695 PGS001977
(portability-PLR_log_SHBG)
PSS008316|
South Asian Ancestry|
5,437 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sex hormone binding globulin (SHBG) Partial Correlation (partial-r): 0.3532 [0.3297, 0.3763] sex, age, birth date, deprivation index, 16 PCs
PPM010696 PGS001977
(portability-PLR_log_SHBG)
PSS008093|
East Asian Ancestry|
1,548 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sex hormone binding globulin (SHBG) Partial Correlation (partial-r): 0.3607 [0.3163, 0.4035] sex, age, birth date, deprivation index, 16 PCs
PPM010697 PGS001977
(portability-PLR_log_SHBG)
PSS007880|
African Ancestry|
2,140 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sex hormone binding globulin (SHBG) Partial Correlation (partial-r): 0.2192 [0.1783, 0.2594] sex, age, birth date, deprivation index, 16 PCs
PPM010698 PGS001977
(portability-PLR_log_SHBG)
PSS008984|
African Ancestry|
3,374 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sex hormone binding globulin (SHBG) Partial Correlation (partial-r): 0.1912 [0.1584, 0.2236] sex, age, birth date, deprivation index, 16 PCs
PPM010691 PGS001977
(portability-PLR_log_SHBG)
PSS009436|
European Ancestry|
17,266 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sex hormone binding globulin (SHBG) Partial Correlation (partial-r): 0.4274 [0.4152, 0.4396] sex, age, birth date, deprivation index, 16 PCs
PPM012407 PGS002195
(portability-ldpred2_log_SHBG)
PSS009436|
European Ancestry|
17,266 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sex hormone binding globulin (SHBG) Partial Correlation (partial-r): 0.417 [0.4046, 0.4292] sex, age, birth date, deprivation index, 16 PCs
PPM012408 PGS002195
(portability-ldpred2_log_SHBG)
PSS009210|
European Ancestry|
3,563 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sex hormone binding globulin (SHBG) Partial Correlation (partial-r): 0.3776 [0.349, 0.4055] sex, age, birth date, deprivation index, 16 PCs
PPM012410 PGS002195
(portability-ldpred2_log_SHBG)
PSS008538|
Greater Middle Eastern Ancestry|
1,025 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sex hormone binding globulin (SHBG) Partial Correlation (partial-r): 0.3852 [0.3312, 0.4366] sex, age, birth date, deprivation index, 16 PCs
PPM012411 PGS002195
(portability-ldpred2_log_SHBG)
PSS008316|
South Asian Ancestry|
5,437 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sex hormone binding globulin (SHBG) Partial Correlation (partial-r): 0.3497 [0.3261, 0.3729] sex, age, birth date, deprivation index, 16 PCs
PPM012412 PGS002195
(portability-ldpred2_log_SHBG)
PSS008093|
East Asian Ancestry|
1,548 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sex hormone binding globulin (SHBG) Partial Correlation (partial-r): 0.3684 [0.3242, 0.4109] sex, age, birth date, deprivation index, 16 PCs
PPM012413 PGS002195
(portability-ldpred2_log_SHBG)
PSS007880|
African Ancestry|
2,140 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sex hormone binding globulin (SHBG) Partial Correlation (partial-r): 0.2151 [0.1741, 0.2554] sex, age, birth date, deprivation index, 16 PCs
PPM012414 PGS002195
(portability-ldpred2_log_SHBG)
PSS008984|
African Ancestry|
3,374 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sex hormone binding globulin (SHBG) Partial Correlation (partial-r): 0.1604 [0.1272, 0.1932] sex, age, birth date, deprivation index, 16 PCs
PPM012409 PGS002195
(portability-ldpred2_log_SHBG)
PSS008764|
European Ancestry|
5,738 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sex hormone binding globulin (SHBG) Partial Correlation (partial-r): 0.3934 [0.3713, 0.4151] sex, age, birth date, deprivation index, 16 PCs
PPM017480 PGS003552
(cont-decay-log_SHBG)
PSS010918|
European Ancestry|
17,359 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: Sex hormone binding globulin (SHBG) partial-R2: 0.18 sex, age, deprivation index, PC1-16
PPM017648 PGS003552
(cont-decay-log_SHBG)
PSS010666|
European Ancestry|
5,599 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: Sex hormone binding globulin (SHBG) partial-R2: 0.15 sex, age, deprivation index, PC1-16
PPM017732 PGS003552
(cont-decay-log_SHBG)
PSS010582|
Greater Middle Eastern Ancestry|
996 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: Sex hormone binding globulin (SHBG) partial-R2: 0.13 sex, age, deprivation index, PC1-16
PPM017816 PGS003552
(cont-decay-log_SHBG)
PSS010246|
European Ancestry|
2,029 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: Sex hormone binding globulin (SHBG) partial-R2: 0.15 sex, age, deprivation index, PC1-16
PPM017900 PGS003552
(cont-decay-log_SHBG)
PSS010498|
South Asian Ancestry|
5,386 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: Sex hormone binding globulin (SHBG) partial-R2: 0.12 sex, age, deprivation index, PC1-16
PPM017984 PGS003552
(cont-decay-log_SHBG)
PSS010414|
East Asian Ancestry|
1,538 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: Sex hormone binding globulin (SHBG) partial-R2: 0.12 sex, age, deprivation index, PC1-16
PPM018068 PGS003552
(cont-decay-log_SHBG)
PSS010330|
African Ancestry|
2,129 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: Sex hormone binding globulin (SHBG) partial-R2: 0.04 sex, age, deprivation index, PC1-16
PPM018152 PGS003552
(cont-decay-log_SHBG)
PSS010750|
African Ancestry|
3,347 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: Sex hormone binding globulin (SHBG) partial-R2: 0.03 sex, age, deprivation index, PC1-16
PPM017564 PGS003552
(cont-decay-log_SHBG)
PSS010834|
European Ancestry|
3,551 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: Sex hormone binding globulin (SHBG) partial-R2: 0.14 sex, age, deprivation index, PC1-16

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007880 2,140 individuals African American or Afro-Caribbean Carribean UKB
PSS010918 17,359 individuals,
47.0 % Male samples
Mean = 56.9 years
Sd = 7.9 years
European white British UKB
PSS010666 5,599 individuals,
46.0 % Male samples
Mean = 54.5 years
Sd = 8.4 years
European Italian UKB
PSS010414 1,538 individuals,
33.0 % Male samples
Mean = 52.5 years
Sd = 7.8 years
East Asian Chinese UKB
PSS008538 1,025 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS000830 2,129 individuals European Participants self-identifying as white MESA
PSS009436 17,266 individuals European UK (+ Ireland) UKB
PSS010834 3,551 individuals,
39.0 % Male samples
Mean = 54.4 years
Sd = 7.5 years
European Polish UKB
PSS009210 3,563 individuals European Poland (NE Europe) UKB
PSS008316 5,437 individuals South Asian India (South Asia) UKB
PSS010582 996 individuals,
60.0 % Male samples
Mean = 51.9 years
Sd = 7.9 years
Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB
PSS010330 2,129 individuals,
37.0 % Male samples
Mean = 52.5 years
Sd = 8.1 years
African American or Afro-Caribbean Caribbean UKB
PSS000744 5,523 individuals African unspecified UKB
PSS000745 979 individuals East Asian UKB
PSS000746 21,313 individuals European Non-British White UKB
PSS000747 6,638 individuals South Asian UKB
PSS000748 57,677 individuals European
(British)
UKB
PSS008984 3,374 individuals African unspecified Nigeria (West Africa) UKB
PSS007186 5,606 individuals African unspecified UKB
PSS007187 1,463 individuals East Asian UKB
PSS007188 21,531 individuals European non-white British ancestry UKB
PSS008093 1,548 individuals East Asian China (East Asia) UKB
PSS007189 6,736 individuals South Asian UKB
PSS007190 58,525 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS010750 3,347 individuals,
47.0 % Male samples
Mean = 51.9 years
Sd = 8.1 years
African unspecified Nigerian UKB
PSS010498 5,386 individuals,
55.0 % Male samples
Mean = 53.2 years
Sd = 8.4 years
South Asian Indian UKB
PSS010246 2,029 individuals,
46.0 % Male samples
Mean = 58.1 years
Sd = 7.0 years
European Ashkenazi UKB
PSS008764 5,738 individuals European Italy (South Europe) UKB