Trait: aspartate aminotransferase measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004736
Description
  • Is a quantification of aspartate aminotransferase, and is commonly used as a marker for liver function.
Trait category
Liver enzyme measurement
Synonyms Aspartate transaminase measurement
Mapped term(s) 2 mapped terms
  • NCIt:C64467
  • SNOMEDCT:45896001

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000673 snpnet.Aspartate_aminotransferase PGP000128 Sinnott-Armstrong N et al. Nat Genet (2021) Aspartate aminotransferase [U/L] aspartate aminotransferase measurement 12,829 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000673/ScoringFiles/PGS000673.txt.gz - Check Terms/Licenses

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001471 PGS000673
(snpnet.Aspartate_aminotransferase)
PSS000649 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Aspartate aminotransferase [U/L] : 0.1564
Spearman's ρ: 0.278
Age, sex, PCs(1-40)
PPM001541 PGS000673
(snpnet.Aspartate_aminotransferase)
PSS000651 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Aspartate aminotransferase [U/L] : 0.1493
Spearman's ρ: 0.285
Age, sex, PCs(1-40)
PPM001506 PGS000673
(snpnet.Aspartate_aminotransferase)
PSS000650 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Aspartate aminotransferase [U/L] : 0.11262
Spearman's ρ: 0.243
Age, sex, PCs(1-40)
PPM001436 PGS000673
(snpnet.Aspartate_aminotransferase)
PSS000648 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Aspartate aminotransferase [U/L] : 0.08343
Spearman's ρ: 0.191
Age, sex, PCs(1-40)
PPM001401 PGS000673
(snpnet.Aspartate_aminotransferase)
PSS000647 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Aspartate aminotransferase [U/L] : 0.10334
Spearman's ρ: 0.103
Age, sex, PCs(1-40)

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000647 5,982 individuals African unspecified UKB
PSS000648 1,070 individuals East Asian UKB
PSS000649 23,483 individuals European Non-British White UKB
PSS000650 7,313 individuals South Asian UKB
PSS000651 63,562 individuals European
(British)
UKB