Trait: uric acid measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004761
Description
  • Is a quantification of uric acid, typically in blood. Uric acid is associated with gout, insulin resistance and cardivascular disease.
Trait category
Cardiovascular measurement
Synonyms 2 synonyms
  • uric acid level
  • uric acid levels
Mapped term(s) SNOMEDCT:86228006

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000755 PRS_SUA PGP000161
Cho SK et al. Sci Rep (2020)
Serum uric acid levels uric acid measurement 14 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000755/ScoringFiles/PGS000755.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001923 PGS000755
(PRS_SUA)
PSS000964 PGP000161
Cho SK et al. Sci Rep (2020)
Reported Trait: Serum uric acid levels β: 0.237 (0.033) Sex, age, BMI, eGFR, diabetes, hypertension, hyperlipidaemia, systolic blood pressure, total cholesterol, HDL cholesterol, triglycerides Only 11 of the 14 SNPs were utilised within the polygenic score
PPM001924 PGS000755
(PRS_SUA)
PSS000965 PGP000161
Cho SK et al. Sci Rep (2020)
Reported Trait: Serum uric acid levels β: 0.211 (0.022) Sex, age, BMI, eGFR, diabetes, hypertension, hyperlipidaemia, systolic blood pressure, total cholesterol, HDL cholesterol, triglycerides Only 13 of the 14 SNPs were utilised within the polygenic score

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000964 1,167 individuals,
40.19 % Male samples
Mean = 64.61 years
Sd = 8.26 years
East Asian
(Korean)
KoGES
PSS000965 2,027 individuals,
56.14 % Male samples
Mean = 39.35 years
Sd = 8.87 years
East Asian
(Korean)