Trait: neutrophil count

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004833
Description
  • Is a quantification of neutrophils in blood.
  • The number of granulocytes (polymorphonuclear leukocytes) in a specified volume of blood, usually 1 cubic millimeter.
Trait category
Hematological measurement
Synonyms blood neutrophil count
Mapped term(s) 4 mapped terms
  • CMO:0000030
  • MedDRA:10029363
  • NCIt:C51950
  • SNOMEDCT:30630007
Child trait(s) neutrophil percentage of leukocytes

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "neutrophil count" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000105
(neut)
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Neutrophil count neutrophil count 512
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000105/ScoringFiles/PGS000105.txt.gz
PGS000106
(neut_p)
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Neutrophil percentage of white cells neutrophil percentage of leukocytes 452
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000106/ScoringFiles/PGS000106.txt.gz
PGS000182
(neut)
PGP000078 |
Vuckovic D et al. Cell (2020)
Neutrophil count neutrophil count 492
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000182/ScoringFiles/PGS000182.txt.gz
PGS000183
(neut_p)
PGP000078 |
Vuckovic D et al. Cell (2020)
Neutrophil percentage of white cells neutrophil percentage of leukocytes 437
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000183/ScoringFiles/PGS000183.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000242 PGS000105
(neut)
PSS000170|
European Ancestry|
81,358 individuals
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Reported Trait: Neutrophil count Pearson correlation coefficent (r): 0.3359 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM000243 PGS000105
(neut)
PSS000144|
European Ancestry|
39,138 individuals
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Reported Trait: Neutrophil count Pearson correlation coefficent (r): 0.3159 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment)
PPM000244 PGS000106
(neut_p)
PSS000171|
European Ancestry|
81,423 individuals
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Reported Trait: Neutrophil percentage of white cells Pearson correlation coefficent (r): 0.2924 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM000245 PGS000106
(neut_p)
PSS000145|
European Ancestry|
39,190 individuals
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Reported Trait: Neutrophil percentage of white cells Pearson correlation coefficent (r): 0.2774 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment)
PPM000556 PGS000182
(neut)
PSS000290|
European Ancestry|
2,314 individuals
PGP000078 |
Vuckovic D et al. Cell (2020)
Reported Trait: Neutrophil count : 0.06859 sex, age, 10 genetic PCs
PPM000536 PGS000182
(neut)
PSS000291|
European Ancestry|
39,260 individuals
PGP000078 |
Vuckovic D et al. Cell (2020)
Reported Trait: Neutrophil count : 0.08009 sex, age, 10 genetic PCs
PPM000537 PGS000183
(neut_p)
PSS000291|
European Ancestry|
39,260 individuals
PGP000078 |
Vuckovic D et al. Cell (2020)
Reported Trait: Neutrophil percentage of white cells : 0.06432 sex, age, 10 genetic PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000290 2,314 individuals European
(French Canadian)
CARTaGENE
PSS000170 81,358 individuals,
45.0 % Male samples
Mean = 57.19 years
Range = [40.19, 72.44] years
European UKB
PSS000171 81,423 individuals,
46.0 % Male samples
Mean = 57.25 years
Range = [39.99, 70.5] years
European UKB
PSS000291 39,260 individuals European INTERVAL
PSS000144 39,138 individuals,
50.0 % Male samples
Mean = 43.84 years
Range = [18.0, 76.4] years
European INTERVAL
PSS000145 39,190 individuals,
50.0 % Male samples
Mean = 43.83 years
Range = [18.0, 76.4] years
European INTERVAL