Trait: testosterone measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004908
Description
  • is a quantification of testosterone, typically in serum. Testosterone is a steroid hormone.Testosterone measurement is used in the diagnosis of precocious or delayed puberty, infertility (in men and women), ovarian tumours, adrenal tumours and pituitary disorders.
Trait category
Other measurement
Synonyms 2 synonyms
  • testosterone level
  • testosterone levels
Mapped term(s) 2 mapped terms
  • NCIt:C75378
  • SNOMEDCT:104957004

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000321 snpnet_Testosterone_combined PGP000097
Flynn E et al. Eur J Hum Genet (2020)
Serum testosterone levels testosterone measurement 7,319 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000321/ScoringFiles/PGS000321.txt.gz
PGS000322 snpnet_Testosterone_female-specific PGP000097
Flynn E et al. Eur J Hum Genet (2020)
Serum testosterone levels in females female
testosterone measurement
7,168 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000322/ScoringFiles/PGS000322.txt.gz
PGS000323 snpnet_Testosterone_male-specific PGP000097
Flynn E et al. Eur J Hum Genet (2020)
Serum testosterone levels in males male
testosterone measurement
8,235 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000323/ScoringFiles/PGS000323.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000865 PGS000321 (snpnet_Testosterone_combined) PSS000421 PGP000097
Flynn E et al. (2020)
Reported Trait: Serum testosterone levels in females : 0.13 age, sex, PCs 1-40, blood draw time, fasting time, sample dilution factor, batch, genotyping array
PPM000862 PGS000321 (snpnet_Testosterone_combined) PSS000422 PGP000097
Flynn E et al. (2020)
Reported Trait: Serum testosterone levels in males : 0.21 age, sex, PCs 1-40, blood draw time, fasting time, sample dilution factor, batch, genotyping array
PPM000864 PGS000322 (snpnet_Testosterone_female-specific) PSS000421 PGP000097
Flynn E et al. (2020)
Reported Trait: Serum testosterone levels in females : 0.18 age, sex, PCs 1-40, blood draw time, fasting time, sample dilution factor, batch, genotyping array
PPM000863 PGS000322 (snpnet_Testosterone_female-specific) PSS000422 PGP000097
Flynn E et al. (2020)
Reported Trait: Serum testosterone levels in males : 0.02 age, sex, PCs 1-40, blood draw time, fasting time, sample dilution factor, batch, genotyping array
PPM000866 PGS000323 (snpnet_Testosterone_male-specific) PSS000421 PGP000097
Flynn E et al. (2020)
Reported Trait: Serum testosterone levels in females : 0.023 age, sex, PCs 1-40, blood draw time, fasting time, sample dilution factor, batch, genotyping array
PPM000861 PGS000323 (snpnet_Testosterone_male-specific) PSS000422 PGP000097
Flynn E et al. (2020)
Reported Trait: Serum testosterone levels in males : 0.31 age, sex, PCs 1-40, blood draw time, fasting time, sample dilution factor, batch, genotyping array

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000421 Blood testosterone levels (UKB field 30850). Individuals taking the following testosterone-related drugs (methyltestosterone, finasteride, dutasteride, testosterone, mesterolone, and cyproterone) were excluded. 28,640 individuals,
0.0 % Male samples
European UKB
PSS000422 Blood testosterone levels (UKB field 30850). Individuals taking the following testosterone-related drugs (methyltestosterone, finasteride, dutasteride, testosterone, mesterolone, and cyproterone) were excluded. 28,601 individuals,
100.0 % Male samples
European UKB