Trait: alcohol dependence measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0007835
Description
  • quantification of some aspect of alcohol dependence or misuse, eg using a cummulative symptom score to determine the severity of a case of alcohol dependence
Trait category
Other measurement
Synonyms alcohol misuse measurement
Mapped term(s) PMID:27151647

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000201 PROB_ALC_COGA PGP000084
Barr PB et al. Transl Psychiatry (2020)
Problematic Alcohol Use alcohol dependence measurement 1,094,954 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000201/ScoringFiles/PGS000201.txt.gz
PGS000202 PROB_ALC_FT12 PGP000084
Barr PB et al. Transl Psychiatry (2020)
Problematic Alcohol Use alcohol dependence measurement 1,083,002 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000202/ScoringFiles/PGS000202.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000629 PGS000202 (PROB_ALC_FT12) PSS000340 PGP000084
Barr PB et al. (2020)
Reported Trait: Alcohol use disorder (DSM-5 criteria count, log-transformed) β: 0.043 ΔR-squared (vs. covariates alone): 0.00456 sex, age of last observation, 10 Genetic PCs
PPM000626 PGS000201 (PROB_ALC_COGA) PSS000339 PGP000084
Barr PB et al. (2020)
Reported Trait: Alcohol use disorder (DSM-5 criteria count, log-transformed) β: 0.099 ΔR-squared (vs. covariates alone): 0.01192 sex, age of last observation, 10 Genetic PCs, genotyping array, data collection site

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000340 1,251 individuals,
45.6 % Male samples
Mean = 21.9 years
Sd = 0.77 years
Range = [21.0, 26.0] years
European
(Finnish)
FinnTwin12 Twin Study
PSS000339 7,599 individuals,
47.16 % Male samples
Mean = 36.94 years
Sd = 14.77 years
Range = [12.0, 91.0] years
European COGA