Trait: creatinine clearance measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0007934
Description
  • The clearance rate of creatinine, that is, the volume of plasma that is cleared of creatinine by the kidneys per unit time. Creatinine clearance is calculated using the level of creatinine in a sample of urine, usually one collected over a period of 24 hours, the corresponding plasma creatinine level, and the volume of urine excreted. It is used as an approximation of the glomerular filtration rate (GFR).
Trait category
Other measurement
Mapped term(s) CMO:0000765

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000679 snpnet.Creatinine_in_urine PGP000128 Sinnott-Armstrong N et al. Nat Genet (2021) Creatinine in urine [umol/L] creatinine clearance measurement 5,469 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000679/ScoringFiles/PGS000679.txt.gz - Check Terms/Licenses

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID) 		Evaluated Score PGS Sample Set ID
(PSS ID) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001512 PGS000679
(snpnet.Creatinine_in_urine)
 PSS000672 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Creatinine in urine [umol/L] — — R²: 0.16585
Spearman's ρ: 0.056		 Age, sex, PCs(1-40) —
PPM001547 PGS000679
(snpnet.Creatinine_in_urine)
 PSS000673 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Creatinine in urine [umol/L] — — R²: 0.14919
Spearman's ρ: 0.077		 Age, sex, PCs(1-40) —
PPM001477 PGS000679
(snpnet.Creatinine_in_urine)
 PSS000671 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Creatinine in urine [umol/L] — — R²: 0.16134
Spearman's ρ: 0.068		 Age, sex, PCs(1-40) —
PPM001442 PGS000679
(snpnet.Creatinine_in_urine)
 PSS000670 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Creatinine in urine [umol/L] — — R²: 0.16547
Spearman's ρ: 0.049		 Age, sex, PCs(1-40) —
PPM001407 PGS000679
(snpnet.Creatinine_in_urine)
 PSS000669 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Creatinine in urine [umol/L] — — R²: 0.11165
Spearman's ρ: 0.035		 Age, sex, PCs(1-40) —

Evaluated Samples

PGS Sample Set ID
(PSS ID) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000669 — — 5,789 individuals — African unspecified — UKB —
PSS000670 — — 1,045 individuals — East Asian — UKB —
PSS000671 — — 22,875 individuals — European Non-British White UKB —
PSS000672 — — 7,009 individuals — South Asian — UKB —
PSS000673 — — 62,142 individuals — European
(British)		 — UKB —