Trait: platelet component distribution width

Experimental Factor Ontology (EFO) Information
Identifier EFO_0007984
Description
  • The determination of the amount of platelet shape changes present in a sample. [ NCI ]
  • Measure of variation in platelet size.
Trait category
Hematological measurement
Synonyms 3 synonyms
  • Platelet Component Distribution Width Measurement
  • PCDW
  • Platelet distribution width
Mapped term(s) 2 mapped terms
  • CMO:0001350
  • NCIt:C111294

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Number of Variants PGS Scoring File (FTP Link)
PGS000108 pdw PGP000051
Xu Y et al. bioRxiv (2020)
Pre
Platelet distribution width 579 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000108/ScoringFiles/PGS000108.txt.gz
PGS000185 pdw PGP000078
Vuckovic D et al. medRxiv (2020)
Pre
Platelet distribution width 555 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000185/ScoringFiles/PGS000185.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000248 PGS000108 (pdw) PSS000173 PGP000051
Xu Y et al. (2020)
Pre
Reported Trait: Platelet distribution width Pearson correlation coefficent (r): 0.4784 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM000249 PGS000108 (pdw) PSS000147 PGP000051
Xu Y et al. (2020)
Pre
Reported Trait: Platelet distribution width Pearson correlation coefficent (r): 0.2701 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment)
PPM000539 PGS000185 (pdw) PSS000291 PGP000078
Vuckovic D et al. (2020)
Pre
Reported Trait: Platelet distribution width : 0.0599616972316209 sex, age, 10 genetic PCs

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000173 78,290 individuals,
46.0 % Male samples
Mean = 57.2 years
Range = [39.99, 70.53] years
European UKB
PSS000291 39,260 individuals European INTERVAL
PSS000147 37,262 individuals,
50.0 % Male samples
Mean = 43.81 years
Range = [18.0, 75.8] years
European INTERVAL