Trait: platelet component distribution width

Experimental Factor Ontology (EFO) Information
Identifier EFO_0007984
Description
  • The determination of the amount of platelet shape changes present in a sample. [ NCI ]
  • Measure of variation in platelet size.
Trait category
Hematological measurement
Synonyms 3 synonyms
  • PCDW
  • Platelet Component Distribution Width Measurement
  • Platelet distribution width
Mapped term(s) 2 mapped terms
  • CMO:0001350
  • NCIt:C111294

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000108
(pdw)
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Platelet distribution width platelet component distribution width 579
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000108/ScoringFiles/PGS000108.txt.gz
PGS000185
(pdw)
PGP000078 |
Vuckovic D et al. Cell (2020)
Platelet distribution width platelet component distribution width 555
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000185/ScoringFiles/PGS000185.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000248 PGS000108
(pdw)
PSS000173|
European Ancestry|
78,290 individuals
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Reported Trait: Platelet distribution width Pearson correlation coefficent (r): 0.4784 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM000249 PGS000108
(pdw)
PSS000147|
European Ancestry|
37,262 individuals
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Reported Trait: Platelet distribution width Pearson correlation coefficent (r): 0.2701 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment)
PPM000539 PGS000185
(pdw)
PSS000291|
European Ancestry|
39,260 individuals
PGP000078 |
Vuckovic D et al. Cell (2020)
Reported Trait: Platelet distribution width : 0.05996 sex, age, 10 genetic PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000173 78,290 individuals,
46.0 % Male samples
Mean = 57.2 years
Range = [39.99, 70.53] years
European UKB
PSS000291 39,260 individuals European INTERVAL
PSS000147 37,262 individuals,
50.0 % Male samples
Mean = 43.81 years
Range = [18.0, 75.8] years
European INTERVAL