Trait: monocyte percentage of leukocytes

Experimental Factor Ontology (EFO) Information
Identifier EFO_0007989
Description
  • A calculated measurement in which the number of monocytes in a specified sample of blood is divided by the total number of white blood cells in the sample, and the result presented as a ratio, fraction, quotient or percentage.
Trait category
Hematological measurement
Synonyms 5 synonyms
  • monocyte percentage
  • monocyte percentage of white cells
  • monocyte count to total WBC count ratio
  • monocyte count as percentage of total white blood cells
  • blood monocyte count to total leukocyte count ratio
Mapped term(s) CMO:0000374

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Number of Variants PGS Scoring File (FTP Link)
PGS000103 mono_p PGP000051
Xu Y et al. bioRxiv (2020)
Monocyte percentage of white cells 583 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000103/ScoringFiles/PGS000103.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000238 PGS000103 (mono_p) PSS000168 PGP000051
Xu Y et al. (2020)
Reported Trait: Monocyte percentage of white cells Pearson correlation coefficent (r): 0.4395 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM000239 PGS000103 (mono_p) PSS000142 PGP000051
Xu Y et al. (2020)
Reported Trait: Monocyte percentage of white cells Pearson correlation coefficent (r): 0.4207 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment)

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000142 39,189 individuals,
50.0 % Male samples
Mean = 43.83 years
Range = [18.0, 76.4] years
European INTERVAL
PSS000168 80,627 individuals,
46.0 % Male samples
Mean = 57.23 years
Range = [40.19, 71.1] years
European UKB