Trait: neutrophil percentage of leukocytes

Experimental Factor Ontology (EFO) Information
Identifier EFO_0007990
Description
  • A calculated measurement in which the number of neutrophil granulocytes is divided by the number of all white blood cells in a specified sample of peripheral venous blood, and the result presented as a ratio, fraction, quotient or percentage. A neutrophil is, or is in the process of becoming, a granular leucocyte having a nucleus with three to five lobes connected by threads of chromatin, cytoplasm containing very fine granules, and which is readily stainable with neutral dyes.
Trait category
Hematological measurement
Synonyms 5 synonyms
  • neutrophil percentage
  • blood neutrophil count to total leukocyte count ratio
  • neutrophil count to total WBC count ratio
  • neutrophil count as percentage of total white blood cells
  • neutrophil percentage of white cells
Mapped term(s) CMO:0000370

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Number of Variants PGS Scoring File (FTP Link)
PGS000106 neut_p PGP000051
Xu Y et al. bioRxiv (2020)
Neutrophil percentage of white cells 452 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000106/ScoringFiles/PGS000106.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000244 PGS000106 (neut_p) PSS000171 PGP000051
Xu Y et al. (2020)
Reported Trait: Neutrophil percentage of white cells Pearson correlation coefficent (r): 0.2924 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM000245 PGS000106 (neut_p) PSS000145 PGP000051
Xu Y et al. (2020)
Reported Trait: Neutrophil percentage of white cells Pearson correlation coefficent (r): 0.2774 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment)

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000145 39,190 individuals,
50.0 % Male samples
Mean = 43.83 years
Range = [18.0, 76.4] years
European INTERVAL
PSS000171 81,423 individuals,
46.0 % Male samples
Mean = 57.25 years
Range = [39.99, 70.5] years
European UKB