Trait: eosinophil percentage of leukocytes

Experimental Factor Ontology (EFO) Information
Identifier EFO_0007991
Description
  • A calculated measurement in which the number of eosinophil granulocytes is divided by the number of all white blood cells in a specified sample of peripheral venous blood, and the result presented as a ratio, fraction, quotient or percentage. An eosinophil is a granular leukocyte having a nucleus with two lobes connected by a thread of chromatin, and cytoplasm containing coarse, round granules of uniform size that stain readily with eosin and other acid dyes.
Trait category
Hematological measurement
Synonyms 5 synonyms
  • eosinophil percentage of white cells
  • eosinophil count as percentage of total white blood cells
  • eosinophil count to total WBC count ratio
  • eosinophil percentage
  • blood eosinophil count to total leukocyte count ratio
Mapped term(s) CMO:0000369

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Number of Variants PGS Scoring File (FTP Link)
PGS000091 eo_p PGP000051
Xu Y et al. bioRxiv (2020)
Pre
Eosinophil percentage of white cells 589 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000091/ScoringFiles/PGS000091.txt.gz
PGS000166 eo_p PGP000078
Vuckovic D et al. medRxiv (2020)
Pre
Eosinophil percentage of white cells 571 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000166/ScoringFiles/PGS000166.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000214 PGS000091 (eo_p) PSS000156 PGP000051
Xu Y et al. (2020)
Pre
Reported Trait: Eosinophil percentage of white cells Pearson correlation coefficent (r): 0.3687 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM000215 PGS000091 (eo_p) PSS000130 PGP000051
Xu Y et al. (2020)
Pre
Reported Trait: Eosinophil percentage of white cells Pearson correlation coefficent (r): 0.3412 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment)
PPM000522 PGS000166 (eo_p) PSS000291 PGP000078
Vuckovic D et al. (2020)
Pre
Reported Trait: Eosinophil percentage of white cells : 0.0978959437205518 sex, age, 10 genetic PCs

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000156 81,283 individuals,
45.0 % Male samples
Mean = 57.19 years
Range = [38.87, 71.1] years
European UKB
PSS000130 40,326 individuals,
49.0 % Male samples
Mean = 43.83 years
Range = [18.0, 76.4] years
European INTERVAL
PSS000291 39,260 individuals European INTERVAL