Trait: lymphocyte percentage of leukocytes

Experimental Factor Ontology (EFO) Information
Identifier EFO_0007993
Description
  • A calculated measurement in which the number of lymphocytes in a specified sample of blood is divided by the total number of white blood cells in the sample, and the result presented as a ratio, fraction, quotient or percentage.
Trait category
Hematological measurement
Synonyms 5 synonyms
  • lymphocyte percentage
  • lymphocyte count to total WBC count ratio
  • blood lymphocyte count to total leukocyte count ratio
  • lymphocyte count as percentage of total white blood cells
  • lymphocyte percentage of white cells
Mapped term(s) CMO:0000371

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Number of Variants PGS Scoring File (FTP Link)
PGS000098 lymph_p PGP000051
Xu Y et al. bioRxiv (2020)
Lymphocyte percentage of white cells 489 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000098/ScoringFiles/PGS000098.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000228 PGS000098 (lymph_p) PSS000163 PGP000051
Xu Y et al. (2020)
Reported Trait: Lymphocyte percentage of white cells Pearson correlation coefficent (r): 0.3046 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM000229 PGS000098 (lymph_p) PSS000137 PGP000051
Xu Y et al. (2020)
Reported Trait: Lymphocyte percentage of white cells Pearson correlation coefficent (r): 0.2817 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment)

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000137 39,178 individuals,
50.0 % Male samples
Mean = 43.82 years
Range = [18.0, 76.4] years
European INTERVAL
PSS000163 81,464 individuals,
46.0 % Male samples
Mean = 57.22 years
Range = [40.17, 71.1] years
European UKB