Trait: left ventricular systolic function measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0008206
Description quantification of some aspect of the systolic function of the left cardiac ventricle such as ventricular fractional shortening or systolic dysfunction
Trait category
Cardiovascular measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000666
(PGS_LVESVi)
 PGP000126 |
Pirruccello JP et al. Nat Commun (2020)
 Body surface area-indexed left ventricular end-systolic volume left ventricular systolic function measurement 28
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000666/ScoringFiles/PGS000666.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001376 PGS000666
(PGS_LVESVi)
 PSS000603|
Ancestry Not Reported|
449,027 individuals
 PGP000126 |
Pirruccello JP et al. Nat Commun (2020)
 Reported Trait: Nonischemic dilated cardiomyopathy OR: 1.51 — — age at enrollment, genotyping array, PCs(1-5) of ancestry. —
PPM001377 PGS000666
(PGS_LVESVi)
 PSS000604|
Multi-ancestry (including European)|
362,922 individuals
 PGP000126 |
Pirruccello JP et al. Nat Commun (2020)
 Reported Trait: Incident nonischemic dilated cardiomyopathy HR: 1.58 [1.43, 1.76] — — cubic basis spline of age at enrollment, sex, genotyping array, PCs(1-5) of ancestry. —
PPM022381 PGS000666
(PGS_LVESVi)
 PSS011932|
European Ancestry|
281 individuals
 PGP000707 |
Claessen G et al. Circulation (2023)
|Ext.		 Reported Trait: Reduced Ejection Fraction — — Hazard ratio (HR, high vs low quartiles): 2.24 [0.96, 6.38] — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011932 — — 281 individuals — European — Pro@Heart, ProAFHeart —
PSS000603 Hospitalization for or death due to ICD-10 code for dilated cardiomyopathy (I42.0); excluding individuals with history of coronary artery disease (as defined below), or history of hypertrophic cardiomyopathy during verbal interview with trained nurse, or hospitalization for or death due to ICD-10 code for hypertrophic cardiomyopathy (I42.1, I42.2) —
[
  • 923 cases
  • , 448,104 controls
]
 — NR — UKB —
PSS000604 Incident DCM: Hospitalization for or death due to ICD-10 code for dilated cardiomyopathy (I42.0); excluding individuals with history of coronary artery disease (as defined below), or history of hypertrophic cardiomyopathy during verbal interview with trained nurse, or hospitalization for or death due to ICD-10 code for hypertrophic cardiomyopathy (I42.1, I42.2).In participants who had not undergone cardiac MRI, were free from CHF, DCM, and CAD at baseline, and who were not identified by the UK Biobank as having third-degree or closer relatedness to another participant. —
[
  • 380 cases
  • , 362,542 controls
]
,
45.0 % Male samples
 Mean = 57.0 years
Sd = 8.1 years		 European, South Asian, African unspecified, East Asian, NR African unspecified = 2937, East Asain = 1303, European = 348778, NR = 3670, South Asian =6234 UKB —