Experimental Factor Ontology (EFO) Information | |
Identifier | EFO_0008206 |
Description | quantification of some aspect of the systolic function of the left cardiac ventricle such as ventricular fractional shortening or systolic dysfunction | Trait category |
Cardiovascular measurement
|
Polygenic Score (PGS) ID | PGS Name | PGS Publication (PGP) ID | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants | PGS Scoring File (FTP Link) |
---|---|---|---|---|---|---|
PGS000666 | PGS_LVESVi | PGP000126 Pirruccello JP et al. Nat Commun (2020) | Body surface area-indexed left ventricular end-systolic volume | left ventricular systolic function measurement | 28 | http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000666/ScoringFiles/PGS000666.txt.gz |
PGS Performance Metric ID (PPM ID) |
Evaluated Score |
PGS Sample Set ID (PSS ID) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
PGS Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|---|
PPM001377 | PGS000666 (PGS_LVESVi) | PSS000604 | PGP000126 Pirruccello JP et al. (2020) |
Reported Trait: Incident nonischemic dilated cardiomyopathy | HR: 1.58 [1.43, 1.76] | — | — | cubic basis spline of age at enrollment, sex, genotyping array, PCs(1-5) of ancestry. | — |
PPM001376 | PGS000666 (PGS_LVESVi) | PSS000603 | PGP000126 Pirruccello JP et al. (2020) |
Reported Trait: Nonischemic dilated cardiomyopathy | OR: 1.51 | — | — | age at enrollment, genotyping array, PCs(1-5) of ancestry. | — |
PGS Sample Set ID (PSS ID) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS000603 | Hospitalization for or death due to ICD-10 code for dilated cardiomyopathy (I42.0); excluding individuals with history of coronary artery disease (as defined below), or history of hypertrophic cardiomyopathy during verbal interview with trained nurse, or hospitalization for or death due to ICD-10 code for hypertrophic cardiomyopathy (I42.1, I42.2) | — | [
|
— | Not reported | — | UKB | — |
PSS000604 | Incident DCM: Hospitalization for or death due to ICD-10 code for dilated cardiomyopathy (I42.0); excluding individuals with history of coronary artery disease (as defined below), or history of hypertrophic cardiomyopathy during verbal interview with trained nurse, or hospitalization for or death due to ICD-10 code for hypertrophic cardiomyopathy (I42.1, I42.2).In participants who had not undergone cardiac MRI, were free from CHF, DCM, and CAD at baseline, and who were not identified by the UK Biobank as having third-degree or closer relatedness to another participant. | — | [ ,
45.0 % Male samples |
Mean = 57.0 years Sd = 8.1 years |
European, South Asian, African unspecified, East Asian, NR | African unpecified = 2937, East Asain = 1303, European = 348778, NR = 3670, South Asian =6234 | UKB | — |