Trait: risk-taking behaviour

Experimental Factor Ontology (EFO) Information
Identifier EFO_0008579
Description
  • The tendency to take risks. Risk-taking behaviour is a characteristic of several psychiatric disorders such as ADHD and bipolar disorder, as well as problem behaviours such as smoking and drug abuse.
Trait category
Biological process

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000205 RISK_PC_COGA PGP000084
Barr PB et al. Transl Psychiatry (2020)
Risk-taking tendency (4-domain principal component model) risk-taking behaviour 1,110,737 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000205/ScoringFiles/PGS000205.txt.gz
PGS000206 RISK_PC_FT12 PGP000084
Barr PB et al. Transl Psychiatry (2020)
Risk-taking tendency (4-domain principal component model) risk-taking behaviour 1,098,765 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000206/ScoringFiles/PGS000206.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000630 PGS000206 (RISK_PC_FT12) PSS000340 PGP000084
Barr PB et al. (2020)
Reported Trait: Alcohol use disorder (DSM-5 criteria count, log-transformed) β: 0.1 ΔR-squared (vs. covariates alone): 0.02273 sex, age of last observation, 10 Genetic PCs
PPM000627 PGS000205 (RISK_PC_COGA) PSS000339 PGP000084
Barr PB et al. (2020)
Reported Trait: Alcohol use disorder (DSM-5 criteria count, log-transformed) β: 0.117 ΔR-squared (vs. covariates alone): 0.01613 sex, age of last observation, 10 Genetic PCs, genotyping array, data collection site

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000340 1,251 individuals,
45.6 % Male samples
Mean = 21.9 years
Sd = 0.77 years
Range = [21.0, 26.0] years
European
(Finnish)
FinnTwin12 Twin Study
PSS000339 7,599 individuals,
47.16 % Male samples
Mean = 36.94 years
Sd = 14.77 years
Range = [12.0, 91.0] years
European COGA