Trait: seeing a general practitioner for nerves, anxiety, tension or depression, self-reported

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009820
Description
  • Seeing a general practitioner for nerves, anxiety, tension or depression, as reported by an individual.
Trait category
Other trait

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Number of Variants PGS Scoring File (FTP Link)
PGS000142 DepAll PGP000068
Cai N et al. Nat Genet (2020)
Probable Depression (low mood or anhedonia, and seen a GP or psychiatrist for nerves, anxiety, tension or depression) 21,908 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000142/ScoringFiles/PGS000142.txt.gz
PGS000140 GPpsy PGP000068
Cai N et al. Nat Genet (2020)
Broad Depression (seen a General Practitioner for nerves, anxiety, tension or depression) 24,665 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000140/ScoringFiles/PGS000140.txt.gz
PGS000143 GPNoDep PGP000068
Cai N et al. Nat Genet (2020)
Seen a General Practitioner for nerves, anxiety, tension or depression (without report of low mood or anhedonia) 21,042 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000143/ScoringFiles/PGS000143.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000435 PGS000143 (GPNoDep) PSS000250 PGP000068
Cai N et al. (2020)
Reported Trait: Major Depressive Disorder status AUROC: 0.5344061 : 0.004712141 Cohort
PPM000432 PGS000140 (GPpsy) PSS000250 PGP000068
Cai N et al. (2020)
Reported Trait: Major Depressive Disorder status AUROC: 0.5319298 : 0.004810792 Cohort
PPM000434 PGS000142 (DepAll) PSS000250 PGP000068
Cai N et al. (2020)
Reported Trait: Major Depressive Disorder status AUROC: 0.5333024 : 0.004918643 Cohort

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000250
[
  • 14,696 cases
  • , 22,013 controls
]
European 15 cohorts
  • BOMA
  • ,CoLaus
  • ,Edinburgh
  • ,GenPOD
  • ,GenRED
  • ,MARS
  • ,MPIP
  • ,NESDA
  • ,QIMR
  • ,RADIANT
  • ,RS
  • ,SHIP
  • ,STAR*D
  • ,TwinGene
  • ,i2b2
Part of PGC29 (PMID: 29700475)