Trait: urinary microalbumin measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0010967
Description The quantification of microalbumin in urine.
Trait category
Other measurement
Mapped term PMID:33462484

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS000690
(snpnet.Microalbumin_in_urine)
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Microalbumin in urine [mg/L] urinary microalbumin measurement 111
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000690/ScoringFiles/PGS000690.txt.gz - Check Terms/Licenses
PGS000972
(GBE_BIN10030500)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Microalbumin [> 40 mg/L] urinary microalbumin measurement 1,097
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000972/ScoringFiles/PGS000972.txt.gz
PGS001967
(portability-PLR_log_microalbumin_urine)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Microalbumin in urine urinary microalbumin measurement 948
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001967/ScoringFiles/PGS001967.txt.gz
PGS002185
(portability-ldpred2_log_microalbumin_urine)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Microalbumin in urine urinary microalbumin measurement 671,610
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002185/ScoringFiles/PGS002185.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001418 PGS000690
(snpnet.Microalbumin_in_urine)
PSS000724|
African Ancestry|
2,679 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Microalbumin in urine [mg/L] : 0.02307
Spearman's ρ: 0.013
Age, sex, PCs(1-40)
PPM001453 PGS000690
(snpnet.Microalbumin_in_urine)
PSS000725|
East Asian Ancestry|
323 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Microalbumin in urine [mg/L] : 0.00102
Spearman's ρ: 0.098
Age, sex, PCs(1-40)
PPM001488 PGS000690
(snpnet.Microalbumin_in_urine)
PSS000726|
European Ancestry|
7,133 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Microalbumin in urine [mg/L] : 0.02086
Spearman's ρ: 0.023
Age, sex, PCs(1-40)
PPM001523 PGS000690
(snpnet.Microalbumin_in_urine)
PSS000727|
South Asian Ancestry|
2,560 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Microalbumin in urine [mg/L] : 0.02677
Spearman's ρ: 0.053
Age, sex, PCs(1-40)
PPM001558 PGS000690
(snpnet.Microalbumin_in_urine)
PSS000728|
European Ancestry|
19,352 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Microalbumin in urine [mg/L] : 0.02007
Spearman's ρ: 0.021
Age, sex, PCs(1-40)
PPM001594 PGS000690
(snpnet.Microalbumin_in_urine)
PSS000834|
European Ancestry|
1,998 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Microalbumin in urine [mg/L] Spearman's ρ: 0.017 Age, sex
PPM007375 PGS000690
(snpnet.Microalbumin_in_urine)
PSS007046|
African Ancestry|
2,909 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Microalbumin in urine : 0.00508 [0.00163, 0.00852]
Incremental R2 (full-covars): 0.0
PGS R2 (no covariates): 0.0 [-0.00007, 0.00008]
age, sex, UKB array type, Genotype PCs
PPM007376 PGS000690
(snpnet.Microalbumin_in_urine)
PSS007047|
East Asian Ancestry|
510 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Microalbumin in urine : 0.08744 [0.06187, 0.11301]
Incremental R2 (full-covars): 2e-05
PGS R2 (no covariates): 0.00542 [-0.00152, 0.01236]
age, sex, UKB array type, Genotype PCs
PPM007377 PGS000690
(snpnet.Microalbumin_in_urine)
PSS007048|
European Ancestry|
7,647 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Microalbumin in urine : 0.00869 [0.00639, 0.01098]
Incremental R2 (full-covars): 0.0
PGS R2 (no covariates): 0.00037 [-0.00011, 0.00085]
age, sex, UKB array type, Genotype PCs
PPM007378 PGS000690
(snpnet.Microalbumin_in_urine)
PSS007049|
South Asian Ancestry|
2,749 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Microalbumin in urine : 0.00601 [0.0026, 0.00942]
Incremental R2 (full-covars): 0.0
PGS R2 (no covariates): 0.00099 [-0.0004, 0.00238]
age, sex, UKB array type, Genotype PCs
PPM007379 PGS000690
(snpnet.Microalbumin_in_urine)
PSS007050|
European Ancestry|
20,988 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Microalbumin in urine : 0.00188 [0.00123, 0.00254]
Incremental R2 (full-covars): 0.0
PGS R2 (no covariates): 6e-05 [-0.00006, 0.00018]
age, sex, UKB array type, Genotype PCs
PPM007668 PGS000972
(GBE_BIN10030500)
PSS003612|
African Ancestry|
6,237 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Microalbumin > 40 mg/L AUROC: 0.56401 [0.54377, 0.58425] : 0.01367
Incremental AUROC (full-covars): 0.00172
PGS R2 (no covariates): 0.00077
PGS AUROC (no covariates): 0.51727 [0.49741, 0.53712]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007669 PGS000972
(GBE_BIN10030500)
PSS003613|
East Asian Ancestry|
1,644 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Microalbumin > 40 mg/L AUROC: 0.62489 [0.57557, 0.6742] : 0.03696
Incremental AUROC (full-covars): 0.02692
PGS R2 (no covariates): 0.00868
PGS AUROC (no covariates): 0.55027 [0.49859, 0.60195]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007670 PGS000972
(GBE_BIN10030500)
PSS003614|
European Ancestry|
24,117 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Microalbumin > 40 mg/L AUROC: 0.62147 [0.60789, 0.63506] : 0.03174
Incremental AUROC (full-covars): 0.00857
PGS R2 (no covariates): 0.00473
PGS AUROC (no covariates): 0.5459 [0.53225, 0.55954]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007671 PGS000972
(GBE_BIN10030500)
PSS003615|
South Asian Ancestry|
7,468 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Microalbumin > 40 mg/L AUROC: 0.60772 [0.58839, 0.62705] : 0.0303
Incremental AUROC (full-covars): 0.01148
PGS R2 (no covariates): 0.00728
PGS AUROC (no covariates): 0.54792 [0.52849, 0.56735]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007672 PGS000972
(GBE_BIN10030500)
PSS003616|
European Ancestry|
65,587 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Microalbumin > 40 mg/L AUROC: 0.61261 [0.60404, 0.62118] : 0.02634
Incremental AUROC (full-covars): 0.01117
PGS R2 (no covariates): 0.00557
PGS AUROC (no covariates): 0.54793 [0.53935, 0.5565]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM010611 PGS001967
(portability-PLR_log_microalbumin_urine)
PSS009456|
European Ancestry|
6,053 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Microalbumin in urine Partial Correlation (partial-r): 0.0727 [0.0475, 0.0977] sex, age, birth date, deprivation index, 16 PCs
PPM010612 PGS001967
(portability-PLR_log_microalbumin_urine)
PSS009230|
European Ancestry|
1,215 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Microalbumin in urine Partial Correlation (partial-r): 0.0331 [-0.0236, 0.0897] sex, age, birth date, deprivation index, 16 PCs
PPM010613 PGS001967
(portability-PLR_log_microalbumin_urine)
PSS008784|
European Ancestry|
2,128 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Microalbumin in urine Partial Correlation (partial-r): 0.0845 [0.042, 0.1268] sex, age, birth date, deprivation index, 16 PCs
PPM010614 PGS001967
(portability-PLR_log_microalbumin_urine)
PSS008558|
Greater Middle Eastern Ancestry|
426 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Microalbumin in urine Partial Correlation (partial-r): 0.0716 [-0.0259, 0.1677] sex, age, birth date, deprivation index, 16 PCs
PPM010615 PGS001967
(portability-PLR_log_microalbumin_urine)
PSS008336|
South Asian Ancestry|
2,181 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Microalbumin in urine Partial Correlation (partial-r): 0.0304 [-0.0118, 0.0725] sex, age, birth date, deprivation index, 16 PCs
PPM010616 PGS001967
(portability-PLR_log_microalbumin_urine)
PSS008113|
East Asian Ancestry|
505 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Microalbumin in urine Partial Correlation (partial-r): 0.0357 [-0.0535, 0.1243] sex, age, birth date, deprivation index, 16 PCs
PPM010617 PGS001967
(portability-PLR_log_microalbumin_urine)
PSS007900|
African Ancestry|
1,112 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Microalbumin in urine Partial Correlation (partial-r): 0.0224 [-0.037, 0.0816] sex, age, birth date, deprivation index, 16 PCs
PPM010618 PGS001967
(portability-PLR_log_microalbumin_urine)
PSS009004|
African Ancestry|
1,818 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Microalbumin in urine Partial Correlation (partial-r): 0.0185 [-0.0278, 0.0647] sex, age, birth date, deprivation index, 16 PCs
PPM012327 PGS002185
(portability-ldpred2_log_microalbumin_urine)
PSS009456|
European Ancestry|
6,053 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Microalbumin in urine Partial Correlation (partial-r): 0.094 [0.0689, 0.119] sex, age, birth date, deprivation index, 16 PCs
PPM012328 PGS002185
(portability-ldpred2_log_microalbumin_urine)
PSS009230|
European Ancestry|
1,215 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Microalbumin in urine Partial Correlation (partial-r): 0.0501 [-0.0067, 0.1065] sex, age, birth date, deprivation index, 16 PCs
PPM012329 PGS002185
(portability-ldpred2_log_microalbumin_urine)
PSS008784|
European Ancestry|
2,128 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Microalbumin in urine Partial Correlation (partial-r): 0.0718 [0.0292, 0.1142] sex, age, birth date, deprivation index, 16 PCs
PPM012331 PGS002185
(portability-ldpred2_log_microalbumin_urine)
PSS008336|
South Asian Ancestry|
2,181 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Microalbumin in urine Partial Correlation (partial-r): 0.0771 [0.0351, 0.1189] sex, age, birth date, deprivation index, 16 PCs
PPM012332 PGS002185
(portability-ldpred2_log_microalbumin_urine)
PSS008113|
East Asian Ancestry|
505 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Microalbumin in urine Partial Correlation (partial-r): 0.0772 [-0.0119, 0.1651] sex, age, birth date, deprivation index, 16 PCs
PPM012333 PGS002185
(portability-ldpred2_log_microalbumin_urine)
PSS007900|
African Ancestry|
1,112 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Microalbumin in urine Partial Correlation (partial-r): 0.0198 [-0.0395, 0.0791] sex, age, birth date, deprivation index, 16 PCs
PPM012334 PGS002185
(portability-ldpred2_log_microalbumin_urine)
PSS009004|
African Ancestry|
1,818 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Microalbumin in urine Partial Correlation (partial-r): 0.0669 [0.0207, 0.1127] sex, age, birth date, deprivation index, 16 PCs
PPM012330 PGS002185
(portability-ldpred2_log_microalbumin_urine)
PSS008558|
Greater Middle Eastern Ancestry|
426 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Microalbumin in urine Partial Correlation (partial-r): 0.0693 [-0.0282, 0.1655] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008784 2,128 individuals European Italy (South Europe) UKB
PSS007900 1,112 individuals African American or Afro-Caribbean Carribean UKB
PSS000834 1,998 individuals European Participants self-identifying as white MESA
PSS008558 426 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009456 6,053 individuals European UK (+ Ireland) UKB
PSS000724 2,679 individuals African unspecified UKB
PSS000725 323 individuals East Asian UKB
PSS000726 7,133 individuals European Non-British White UKB
PSS000727 2,560 individuals South Asian UKB
PSS000728 19,352 individuals European
(British)
UKB
PSS007046 2,909 individuals African unspecified UKB
PSS007047 510 individuals East Asian UKB
PSS007048 7,647 individuals European non-white British ancestry UKB
PSS007049 2,749 individuals South Asian UKB
PSS007050 20,988 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS009230 1,215 individuals European Poland (NE Europe) UKB
PSS008336 2,181 individuals South Asian India (South Asia) UKB
PSS003612
[
  • 933 cases
  • , 5,304 controls
]
African unspecified UKB
PSS003613
[
  • 142 cases
  • , 1,502 controls
]
East Asian UKB
PSS003614
[
  • 1,842 cases
  • , 22,275 controls
]
European non-white British ancestry UKB
PSS003615
[
  • 982 cases
  • , 6,486 controls
]
South Asian UKB
PSS003616
[
  • 4,718 cases
  • , 60,869 controls
]
European white British ancestry UKB Testing cohort (heldout set)
PSS009004 1,818 individuals African unspecified Nigeria (West Africa) UKB
PSS008113 505 individuals East Asian China (East Asia) UKB