Trait: kidney failure

Experimental Factor Ontology (EFO) Information
Identifier EFO_1002048
Description An acute or chronic condition that is characterized by the inability of the kidneys to adequately filter the blood. [NCIT: P378]
Trait category
Other disease
Synonyms 5 synonyms
  • failure, renal
  • kidney failure
  • renal failure
  • renal failure syndrome
  • renal insufficiency
Mapped term(s) 11 mapped terms
  • DOID:1074
  • ICD10:N19
  • ICD9:404.12
  • ICD9:404.13
  • ICD9:586
  • MESH:D051437
  • MONDO:0001106
  • NCIT:C4376
  • SCTID:42399005
  • UMLS:C0035078
  • UMLS:C1565489

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000708 HC294 PGP000128 Sinnott-Armstrong N et al. Nat Genet (2021) Kidney failure kidney failure 183,272 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000708/ScoringFiles/PGS000708.txt.gz - Check Terms/Licenses

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001608 PGS000708
(HC294)
PSS000829 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Renal failure HR: 1.12 [1.08, 1.16] C-index: 0.667 Age as time scale, sex, batch, PCs(1-10)
PPM001600 PGS000708
(HC294)
PSS000823 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Kidney failure AUROC: 0.56142 Age, sex, PCs(1-10)
PPM001609 PGS000708
(HC294)
PSS000804 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Dialysis HR: 1.13 [1.04, 1.23] C-index: 0.745 Age as time scale, sex, batch, PCs(1-10)
PPM001610 PGS000708
(HC294)
PSS000682 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Diabetic kidney failure in all HR: 1.19 [1.13, 1.26] C-index: 0.779 Age as time scale, sex, batch, PCs(1-10)
PPM001611 PGS000708
(HC294)
PSS000682 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Diabetic kidney failure in diabetics HR: 1.08 [1.02, 1.14] C-index: 0.706 Age as time scale, sex, batch, PCs(1-10)
PPM001612 PGS000708
(HC294)
PSS000683 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Diabetic kidney failure in type 2 diabetics HR: 1.13 [1.04, 1.24] C-index: 0.634 Age as time scale, sex, batch, PCs(1-10)

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000682 ICD-10 E1[0-4]2
[
  • 1,299 cases
  • , 134,001 controls
]
European
(Finnish)
FinnGen
PSS000683 ICD-10 E1[0-4]2
[
  • 511 cases
  • , 134,789 controls
]
European
(Finnish)
FinnGen
PSS000823 87,413 individuals European UKB
PSS000829 ICD-10 N17
[
  • 3,058 cases
  • , 132,242 controls
]
European
(Finnish)
FinnGen
PSS000804 ICD-10 Z992|Y841
[
  • 595 cases
  • , 134,705 controls
]
European
(Finnish)
FinnGen