Trait: follicular lymphoma

Trait Information
Identifier MONDO_0018906
Description Follicular lymphoma is a form of non-Hodgkin lymphoma characterized by a proliferation of B cells whose nodular structure of follicular architecture is preserved. [Orphanet: 545]
Trait category
Cancer
Immune system disorder
Synonyms 6 synonyms
  • follicle center lymphoma
  • follicular centre cell lymphoma
  • follicular non-Hodgkin lymphoma
  • follicular non-Hodgkin's lymphoma
  • lymphoma, follicular centre cell
  • lymphoma, follicular, malignant
Mapped term(s) 19 mapped terms
  • DOID:0050873
  • GARD:0002356
  • HGNC:990
  • ICD10:C82.0
  • ICD10:C82.1
  • ICD10:C82.2
  • ICD10:C82.3
  • ICD10:C82.4
  • ICD10:C82.5
  • ICD10:C82.6
  • ICD10:C82.7
  • ICD10:C82.9
  • ICDO:9690/3
  • MESH:D008224
  • NCIT:C3209
  • ONCOTREE:FL
  • Orphanet:545
  • SCTID:308121000
  • UMLS:C0024301

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000643 PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_PRS-CS_MGI_20200608 PGP000118 Fritsche LG et al. Am J Hum Genet (2020) Nodular lymphoma follicular lymphoma 1,048,780 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000643/ScoringFiles/PGS000643.txt.gz
PGS000644 PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_LASSOSUM_MGI_20200608 PGP000118 Fritsche LG et al. Am J Hum Genet (2020) Nodular lymphoma follicular lymphoma 2,209,179 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000644/ScoringFiles/PGS000644.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001329 PGS000644 (PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_LASSOSUM_MGI_20200608) PSS000560 PGP000118
Fritsche LG et al. (2020)
Reported Trait: Nodular lymphoma OR: 1.149 [1.021, 1.294]
β: 0.139 (0.0606)
AUROC: 0.538 [0.504, 0.573] Nagelkerke's Pseudo-R²: 0.00349
Brier score: 0.0825
Odds Ratio (OR, top 1% vs. Rest): 1.48 [0.538, 4.05]
age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_LASSOSUM_MGI_20200608
PPM001328 PGS000643 (PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_PRS-CS_MGI_20200608) PSS000560 PGP000118
Fritsche LG et al. (2020)
Reported Trait: Nodular lymphoma OR: 1.133 [1.005, 1.277]
β: 0.125 (0.061)
AUROC: 0.532 [0.497, 0.568] Nagelkerke's Pseudo-R²: 0.00282
Brier score: 0.0825
Odds Ratio (OR, top 1% vs. Rest): 2.49 [1.1, 5.65]
age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_PRS-CS_MGI_20200608

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000560 PheCode:202.21; ICD9CM:202.00, 202.01, 202.02, 202.03, 202.04, 202.05, 202.06, 202.07, 202.08; ICD10CM:C82, C82.0, C82.00, C82.01, C82.02, C82.03, C82.04, C82.05, C82.06, C82.07, C82.08, C82.09, C82.1, C82.10, C82.11, C82.12, C82.13, C82.14, C82.15, C82.16, C82.17, C82.18, C82.19, C82.2, C82.20, C82.21, C82.22, C82.23, C82.24, C82.25, C82.26, C82.27, C82.28, C82.29, C82.3, C82.30, C82.31, C82.32, C82.33, C82.34, C82.35, C82.36, C82.37, C82.38, C82.39, C82.4, C82.40, C82.41, C82.42, C82.43, C82.44, C82.45, C82.46, C82.47, C82.48, C82.49, C82.5, C82.50, C82.51, C82.52, C82.53, C82.54, C82.55, C82.56, C82.57, C82.58, C82.59, C82.6, C82.60, C82.61, C82.62, C82.63, C82.64, C82.65, C82.66, C82.67, C82.68, C82.69, C82.8, C82.80, C82.81, C82.82, C82.83, C82.84, C82.85, C82.86, C82.87, C82.88, C82.89, C82.9, C82.90, C82.91, C82.92, C82.93, C82.94, C82.95, C82.96, C82.97, C82.98, C82.99
[
  • 296 cases
  • , 2,960 controls
]
European MGI