Trait: female

Trait Information
Identifier PATO_0000383
Description
  • A biological sex quality inhering in an individual or a population that only produces gametes that can be fertilised by male gametes.
Trait category
Sex-specific PGS
Mapped term(s) 6 mapped terms
  • CARO:0000028
  • SNOMEDCT:248152002
  • MSH:D005260
  • MO:506
  • NCIt:C16576
  • PATO:0000383

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000318 cPRS_F PGP000095
Meisner A et al. Am J Hum Genet (2020)
All-cause mortality (female) age at death
female
4,122 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000318/ScoringFiles/PGS000318.txt.gz
PGS000322 snpnet_Testosterone_female-specific PGP000097
Flynn E et al. Eur J Hum Genet (2020)
Serum testosterone levels in females female
testosterone measurement
7,168 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000322/ScoringFiles/PGS000322.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000856 PGS000318 (cPRS_F) PSS000409 PGP000095
Meisner A et al. (2020)
Reported Trait: Years of life lost (females) β: 0.58[-0.11, 1.26] 10 genetic PCs, risk factors measured at baseline (BMI, smoking status, alcohol consumption, SBP, DBP, eGFR, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, blood glucose, and sleep duration)
PPM000854 PGS000318 (cPRS_F) PSS000409 PGP000095
Meisner A et al. (2020)
Reported Trait: All-cause mortality (age at death in females) HR: 1.06[0.99, 1.13] 10 genetic PCs, risk factors measured at baseline (BMI, smoking status, alcohol consumption, SBP, DBP, eGFR, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, blood glucose, and sleep duration)
PPM000852 PGS000318 (cPRS_F) PSS000409 PGP000095
Meisner A et al. (2020)
Reported Trait: Years of life lost (females) β: 0.97[0.5, 1.44] 10 genetic PCs
PPM000850 PGS000318 (cPRS_F) PSS000409 PGP000095
Meisner A et al. (2020)
Reported Trait: All-cause mortality (age at death in females) HR: 1.1[1.05, 1.16] 10 genetic PCs
PPM000863 PGS000322 (snpnet_Testosterone_female-specific) PSS000422 PGP000097
Flynn E et al. (2020)
Reported Trait: Serum testosterone levels in males : 0.02 age, sex, PCs 1-40, blood draw time, fasting time, sample dilution factor, batch, genotyping array
PPM000864 PGS000322 (snpnet_Testosterone_female-specific) PSS000421 PGP000097
Flynn E et al. (2020)
Reported Trait: Serum testosterone levels in females : 0.18 age, sex, PCs 1-40, blood draw time, fasting time, sample dilution factor, batch, genotyping array

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000409 The death registry data were available through November 30, 2016, for the centers in Scotland and January 31, 2018, for the centers in England and Wales. We determined whether an individual died of a particular disease by considering the ICD-10 code listed as the primary cause of death Mean = 8.8 years
Sd = 1.0 years
[
  • 1,720 cases
  • , 58,588 controls
]
,
0.0 % Male samples
Mean (Baseline) = 57.2 years
Sd = 7.9 years
European UKB
PSS000421 Blood testosterone levels (UKB field 30850). Individuals taking the following testosterone-related drugs (methyltestosterone, finasteride, dutasteride, testosterone, mesterolone, and cyproterone) were excluded. 28,640 individuals,
0.0 % Male samples
European UKB
PSS000422 Blood testosterone levels (UKB field 30850). Individuals taking the following testosterone-related drugs (methyltestosterone, finasteride, dutasteride, testosterone, mesterolone, and cyproterone) were excluded. 28,601 individuals,
100.0 % Male samples
European UKB