PGS Publication: PGP000084

Publication Information (EuropePMC)
Title Using polygenic scores for identifying individuals at increased risk of substance use disorders in clinical and population samples.
PubMed ID 32555147(Europe PMC)
doi 10.1038/s41398-020-00865-8
Publication Date June 18, 2020
Journal Transl Psychiatry
Author(s) Barr PB, Ksinan A, Su J, Johnson EC, Meyers JL, Wetherill L, Latvala A, Aliev F, Chan G, Kuperman S, Nurnberger J, Kamarajan C, Anokhin A, Agrawal A, Rose RJ, Edenberg HJ, Schuckit M, Kaprio J, Dick DM.
Released in PGS: July 1, 2020

Associated Polygenic Score(s)

PGS Developed By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000202 PROB_ALC_FT12 PGP000084
Barr PB et al. Transl Psychiatry (2020)
Problematic Alcohol Use alcohol dependence measurement 1,083,002 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000202/ScoringFiles/PGS000202.txt.gz
PGS000206 RISK_PC_FT12 PGP000084
Barr PB et al. Transl Psychiatry (2020)
Risk-taking tendency (4-domain principal component model) risk-taking behaviour 1,098,765 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000206/ScoringFiles/PGS000206.txt.gz
PGS000203 GSCAN_DPW_COGA PGP000084
Barr PB et al. Transl Psychiatry (2020)
Alcohol consumption (drinks per week) alcohol consumption measurement 1,110,910 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000203/ScoringFiles/PGS000203.txt.gz
PGS000204 GSCAN_DPW_FT12 PGP000084
Barr PB et al. Transl Psychiatry (2020)
Alcohol consumption (drinks per week) alcohol consumption measurement 1,099,480 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000204/ScoringFiles/PGS000204.txt.gz
PGS000205 RISK_PC_COGA PGP000084
Barr PB et al. Transl Psychiatry (2020)
Risk-taking tendency (4-domain principal component model) risk-taking behaviour 1,110,737 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000205/ScoringFiles/PGS000205.txt.gz
PGS000201 PROB_ALC_COGA PGP000084
Barr PB et al. Transl Psychiatry (2020)
Problematic Alcohol Use alcohol dependence measurement 1,094,954 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000201/ScoringFiles/PGS000201.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000629 PGS000202 (PROB_ALC_FT12) PSS000340 PGP000084
Barr PB et al. (2020)
Reported Trait: Alcohol use disorder (DSM-5 criteria count, log-transformed) β: 0.043 ΔR-squared (vs. covariates alone): 0.00456 sex, age of last observation, 10 Genetic PCs
PPM000630 PGS000206 (RISK_PC_FT12) PSS000340 PGP000084
Barr PB et al. (2020)
Reported Trait: Alcohol use disorder (DSM-5 criteria count, log-transformed) β: 0.1 ΔR-squared (vs. covariates alone): 0.02273 sex, age of last observation, 10 Genetic PCs
PPM000625 PGS000203 (GSCAN_DPW_COGA) PSS000339 PGP000084
Barr PB et al. (2020)
Reported Trait: Alcohol use disorder (DSM-5 criteria count, log-transformed) β: 0.121 ΔR-squared (vs. covariates alone): 0.01734 sex, age of last observation, 10 Genetic PCs, genotyping array, data collection site
PPM000628 PGS000204 (GSCAN_DPW_FT12) PSS000340 PGP000084
Barr PB et al. (2020)
Reported Trait: Alcohol use disorder (DSM-5 criteria count, log-transformed) β: 0.114 ΔR-squared (vs. covariates alone): 0.0298 sex, age of last observation, 10 Genetic PCs
PPM000627 PGS000205 (RISK_PC_COGA) PSS000339 PGP000084
Barr PB et al. (2020)
Reported Trait: Alcohol use disorder (DSM-5 criteria count, log-transformed) β: 0.117 ΔR-squared (vs. covariates alone): 0.01613 sex, age of last observation, 10 Genetic PCs, genotyping array, data collection site
PPM000626 PGS000201 (PROB_ALC_COGA) PSS000339 PGP000084
Barr PB et al. (2020)
Reported Trait: Alcohol use disorder (DSM-5 criteria count, log-transformed) β: 0.099 ΔR-squared (vs. covariates alone): 0.01192 sex, age of last observation, 10 Genetic PCs, genotyping array, data collection site

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000340 1,251 individuals,
45.6 % Male samples
Mean = 21.9 years
Sd = 0.77 years
Range = [21.0, 26.0] years
European
(Finnish)
FinnTwin12 Twin Study
PSS000339 7,599 individuals,
47.16 % Male samples
Mean = 36.94 years
Sd = 14.77 years
Range = [12.0, 91.0] years
European COGA