PGS Publication: PGP000089

Publication Information (EuropePMC)
Title Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals.
PubMed ID 33067605(Europe PMC)
doi 10.1038/s42255-020-00287-2
Publication Date Oct. 16, 2020
Journal Nat Metab
Author(s) Folkersen L, Gustafsson S, Wang Q, Hansen DH, Hedman ÅK, Schork A, Page K, Zhernakova DV, Wu Y, Peters J, Eriksson N, Bergen SE, Boutin TS, Bretherick AD, Enroth S, Kalnapenkis A, Gådin JR, Suur BE, Chen Y, Matic L, Gale JD, Lee J, Zhang W, Quazi A, Ala-Korpela M, Choi SH, Claringbould A, Danesh J, Davey Smith G, de Masi F, Elmståhl S, Engström G, Fauman E, Fernandez C, Franke L, Franks PW, Giedraitis V, Haley C, Hamsten A, Ingason A, Johansson Å, Joshi PK, Lind L, Lindgren CM, Lubitz S, Palmer T, Macdonald-Dunlop E, Magnusson M, Melander O, Michaelsson K, Morris AP, Mägi R, Nagle MW, Nilsson PM, Nilsson J, Orho-Melander M, Polasek O, Prins B, Pålsson E, Qi T, Sjögren M, Sundström J, Surendran P, Võsa U, Werge T, Wernersson R, Westra HJ, Yang J, Zhernakova A, Ärnlöv J, Fu J, Smith JG, Esko T, Hayward C, Gyllensten U, Landen M, Siegbahn A, Wilson JF, Wallentin L, Butterworth AS, Holmes MV, Ingelsson E, Mälarstig A.
Released in PGS Catalog: Oct. 19, 2020

Associated Polygenic Score(s)

PGS Developed By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000217 ADM PGP000089 Folkersen L et al. Nat Metab (2020) Adrenomedullin (ADM) serum levels blood protein measurement 552,255 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000217/ScoringFiles/PGS000217.txt.gz
PGS000218 AGRP PGP000089 Folkersen L et al. Nat Metab (2020) Agouti-related protein (AGRP) serum levels blood protein measurement 552,255 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000218/ScoringFiles/PGS000218.txt.gz
PGS000219 CA-125 PGP000089 Folkersen L et al. Nat Metab (2020) Ovarian cancer-related tumor marker CA 125 (CA-125) serum levels blood protein measurement 553,820 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000219/ScoringFiles/PGS000219.txt.gz
PGS000228 CTSL1 PGP000089 Folkersen L et al. Nat Metab (2020) Cathepsin L1 (CTSL1) serum levels blood protein measurement 552,085 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000228/ScoringFiles/PGS000228.txt.gz
PGS000229 CX3CL1 PGP000089 Folkersen L et al. Nat Metab (2020) Fractalkine (CX3CL1) serum levels blood protein measurement 552,275 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000229/ScoringFiles/PGS000229.txt.gz
PGS000230 CXCL1 PGP000089 Folkersen L et al. Nat Metab (2020) C-X-C motif chemokine 1 (CXCL1) serum levels blood protein measurement 552,235 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000230/ScoringFiles/PGS000230.txt.gz
PGS000220 CCL20 PGP000089 Folkersen L et al. Nat Metab (2020) C-C motif chemokine 20 (CCL20) serum levels blood protein measurement 551,990 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000220/ScoringFiles/PGS000220.txt.gz
PGS000221 CCL3 PGP000089 Folkersen L et al. Nat Metab (2020) C-C motif chemokine 3 (CCL3) serum levels blood protein measurement 552,348 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000221/ScoringFiles/PGS000221.txt.gz
PGS000222 CCL4 PGP000089 Folkersen L et al. Nat Metab (2020) C-C motif chemokine 4 (CCL4) serum levels blood protein measurement 552,215 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000222/ScoringFiles/PGS000222.txt.gz
PGS000223 CD40 PGP000089 Folkersen L et al. Nat Metab (2020) Tumor necrosis factor receptor superfamily member 5 (CD40) serum levels blood protein measurement 552,188 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000223/ScoringFiles/PGS000223.txt.gz
PGS000224 CHI3L1 PGP000089 Folkersen L et al. Nat Metab (2020) Chitinase-3-like protein 1 (CHI3L1) serum levels blood protein measurement 552,107 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000224/ScoringFiles/PGS000224.txt.gz
PGS000225 CSF-1 PGP000089 Folkersen L et al. Nat Metab (2020) Macrophage colony-stimulating factor 1 (CSF-1) serum levels blood protein measurement 552,164 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000225/ScoringFiles/PGS000225.txt.gz
PGS000226 CSTB PGP000089 Folkersen L et al. Nat Metab (2020) Cystatin-B (CSTB) serum levels blood protein measurement 552,196 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000226/ScoringFiles/PGS000226.txt.gz
PGS000227 CTSD PGP000089 Folkersen L et al. Nat Metab (2020) Cathepsin D (CTSD) serum levels blood protein measurement 552,135 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000227/ScoringFiles/PGS000227.txt.gz
PGS000231 CXCL16 PGP000089 Folkersen L et al. Nat Metab (2020) C-X-C motif chemokine 16 (CXCL16) serum levels blood protein measurement 552,242 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000231/ScoringFiles/PGS000231.txt.gz
PGS000232 CXCL6 PGP000089 Folkersen L et al. Nat Metab (2020) C-X-C motif chemokine 6 (CXCL6) serum levels blood protein measurement 552,062 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000232/ScoringFiles/PGS000232.txt.gz
PGS000233 Dkk-1 PGP000089 Folkersen L et al. Nat Metab (2020) Dickkopf-related protein 1 (Dkk-1) serum levels blood protein measurement 552,068 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000233/ScoringFiles/PGS000233.txt.gz
PGS000234 ECP PGP000089 Folkersen L et al. Nat Metab (2020) Eosinophil cationic protein (ECP) serum levels blood protein measurement 553,047 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000234/ScoringFiles/PGS000234.txt.gz
PGS000235 EGF PGP000089 Folkersen L et al. Nat Metab (2020) Epidermal growth factor (EGF) serum levels blood protein measurement 553,164 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000235/ScoringFiles/PGS000235.txt.gz
PGS000236 ESM-1 PGP000089 Folkersen L et al. Nat Metab (2020) Endothelial cell-specific molecule 1 (ESM-1) serum levels blood protein measurement 553,241 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000236/ScoringFiles/PGS000236.txt.gz
PGS000237 FABP4 PGP000089 Folkersen L et al. Nat Metab (2020) Fatty acid-binding protein, adipocyte (FABP4) serum levels blood protein measurement 552,344 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000237/ScoringFiles/PGS000237.txt.gz
PGS000238 FAS PGP000089 Folkersen L et al. Nat Metab (2020) Tumor necrosis factor receptor superfamily member 6 (FAS) serum levels blood protein measurement 552,336 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000238/ScoringFiles/PGS000238.txt.gz
PGS000239 FGF-23 PGP000089 Folkersen L et al. Nat Metab (2020) Fibroblast growth factor 23 (FGF-23) serum levels blood protein measurement 552,101 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000239/ScoringFiles/PGS000239.txt.gz
PGS000240 FS PGP000089 Folkersen L et al. Nat Metab (2020) Follistatin (FS) serum levels blood protein measurement 552,139 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000240/ScoringFiles/PGS000240.txt.gz
PGS000241 GAL PGP000089 Folkersen L et al. Nat Metab (2020) Galanin peptides (GAL) serum levels blood protein measurement 553,549 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000241/ScoringFiles/PGS000241.txt.gz
PGS000242 Gal-3 PGP000089 Folkersen L et al. Nat Metab (2020) Galectin-3 (Gal-3) serum levels blood protein measurement 552,283 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000242/ScoringFiles/PGS000242.txt.gz
PGS000244 GH PGP000089 Folkersen L et al. Nat Metab (2020) Growth hormone (GH) serum levels blood protein measurement 552,237 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000244/ScoringFiles/PGS000244.txt.gz
PGS000246 HGF PGP000089 Folkersen L et al. Nat Metab (2020) Hepatocyte growth factor (HGF) serum levels blood protein measurement 552,105 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000246/ScoringFiles/PGS000246.txt.gz
PGS000245 HB-EGF PGP000089 Folkersen L et al. Nat Metab (2020) Proheparin-binding EGF-like growth factor (HB-EGF) serum levels blood protein measurement 552,109 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000245/ScoringFiles/PGS000245.txt.gz
PGS000248 HSP_27 PGP000089 Folkersen L et al. Nat Metab (2020) Heat shock 27 kDa protein (HSP_27) serum levels blood protein measurement 552,213 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000248/ScoringFiles/PGS000248.txt.gz
PGS000247 hK11 PGP000089 Folkersen L et al. Nat Metab (2020) Kallikrein-11 (hK11) serum levels blood protein measurement 553,240 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000247/ScoringFiles/PGS000247.txt.gz
PGS000250 IL-1ra PGP000089 Folkersen L et al. Nat Metab (2020) Interleukin-1 receptor antagonist protein (IL-1ra) serum levels blood protein measurement 551,918 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000250/ScoringFiles/PGS000250.txt.gz
PGS000249 IL-18 PGP000089 Folkersen L et al. Nat Metab (2020) Interleukin-18 (IL-18) serum levels blood protein measurement 552,187 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000249/ScoringFiles/PGS000249.txt.gz
PGS000252 IL-6 PGP000089 Folkersen L et al. Nat Metab (2020) Interleukin-6 (IL-6) serum levels blood protein measurement 552,427 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000252/ScoringFiles/PGS000252.txt.gz
PGS000251 IL-27 PGP000089 Folkersen L et al. Nat Metab (2020) Interleukin-27 (IL-27) serum levels blood protein measurement 552,027 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000251/ScoringFiles/PGS000251.txt.gz
PGS000254 IL-8 PGP000089 Folkersen L et al. Nat Metab (2020) Interleukin-8 (IL-8) serum levels blood protein measurement 551,991 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000254/ScoringFiles/PGS000254.txt.gz
PGS000253 IL-6RA PGP000089 Folkersen L et al. Nat Metab (2020) Interleukin-6 receptor subunit alpha (IL-6RA) serum levels blood protein measurement 552,133 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000253/ScoringFiles/PGS000253.txt.gz
PGS000256 ITGB1BP2 PGP000089 Folkersen L et al. Nat Metab (2020) Melusin (ITGB1BP2) serum levels blood protein measurement 552,424 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000256/ScoringFiles/PGS000256.txt.gz
PGS000255 IL16 PGP000089 Folkersen L et al. Nat Metab (2020) Pro-interleukin-16 (IL16) serum levels blood protein measurement 551,885 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000255/ScoringFiles/PGS000255.txt.gz
PGS000258 KLK6 PGP000089 Folkersen L et al. Nat Metab (2020) Kallikrein-6 (KLK6) serum levels blood protein measurement 552,054 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000258/ScoringFiles/PGS000258.txt.gz
PGS000257 KIM-1 PGP000089 Folkersen L et al. Nat Metab (2020) Kidney injury molecule 1 (KIM-1) serum levels blood protein measurement 552,063 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000257/ScoringFiles/PGS000257.txt.gz
PGS000260 LOX-1 PGP000089 Folkersen L et al. Nat Metab (2020) Lectin-like oxidized LDL receptor 1 (LOX-1) serum levels blood protein measurement 552,046 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000260/ScoringFiles/PGS000260.txt.gz
PGS000259 LEP PGP000089 Folkersen L et al. Nat Metab (2020) Leptin (LEP) serum levels blood protein measurement 552,111 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000259/ScoringFiles/PGS000259.txt.gz
PGS000262 MB PGP000089 Folkersen L et al. Nat Metab (2020) Myoglobin (MB) serum levels blood protein measurement 552,172 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000262/ScoringFiles/PGS000262.txt.gz
PGS000261 mAmP PGP000089 Folkersen L et al. Nat Metab (2020) Membrane-bound aminopeptidase P (mAmP) serum levels blood protein measurement 553,071 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000261/ScoringFiles/PGS000261.txt.gz
PGS000264 MMP-1 PGP000089 Folkersen L et al. Nat Metab (2020) Matrix metalloproteinase-1 (MMP-1) serum levels blood protein measurement 552,117 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000264/ScoringFiles/PGS000264.txt.gz
PGS000265 MMP-10 PGP000089 Folkersen L et al. Nat Metab (2020) Matrix metalloproteinase-10 (MMP-10) serum levels blood protein measurement 552,073 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000265/ScoringFiles/PGS000265.txt.gz
PGS000263 MCP-1 PGP000089 Folkersen L et al. Nat Metab (2020) Monocyte chemotactic protein 1 (MCP-1) serum levels blood protein measurement 552,001 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000263/ScoringFiles/PGS000263.txt.gz
PGS000267 MMP-3 PGP000089 Folkersen L et al. Nat Metab (2020) Matrix metalloproteinase-3 (MMP-3) serum levels blood protein measurement 552,329 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000267/ScoringFiles/PGS000267.txt.gz
PGS000266 MMP-12 PGP000089 Folkersen L et al. Nat Metab (2020) Matrix metalloproteinase-12 (MMP-12) serum levels blood protein measurement 552,022 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000266/ScoringFiles/PGS000266.txt.gz
PGS000269 MPO PGP000089 Folkersen L et al. Nat Metab (2020) Myeloperoxidase (MPO) serum levels blood protein measurement 552,279 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000269/ScoringFiles/PGS000269.txt.gz
PGS000270 NT-pro_BNP PGP000089 Folkersen L et al. Nat Metab (2020) N-terminal prohormone brain natriuretic peptide (NT-pro_BNP) serum levels blood protein measurement 554,138 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000270/ScoringFiles/PGS000270.txt.gz
PGS000268 MMP-7 PGP000089 Folkersen L et al. Nat Metab (2020) Matrix metalloproteinase-7 (MMP-7) serum levels blood protein measurement 552,053 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000268/ScoringFiles/PGS000268.txt.gz
PGS000272 PAPPA PGP000089 Folkersen L et al. Nat Metab (2020) Pappalysin-1 (PAPPA) serum levels blood protein measurement 552,299 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000272/ScoringFiles/PGS000272.txt.gz
PGS000271 OPG PGP000089 Folkersen L et al. Nat Metab (2020) Osteoprotegerin (OPG) serum levels blood protein measurement 552,206 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000271/ScoringFiles/PGS000271.txt.gz
PGS000275 PECAM-1 PGP000089 Folkersen L et al. Nat Metab (2020) Platelet endothelial cell adhesion molecule (PECAM-1) serum levels blood protein measurement 552,011 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000275/ScoringFiles/PGS000275.txt.gz
PGS000274 PDGF_subunit_B PGP000089 Folkersen L et al. Nat Metab (2020) Platelet-derived growth factor subunit B (PDGF_subunit_B) serum levels blood protein measurement 552,266 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000274/ScoringFiles/PGS000274.txt.gz
PGS000273 PAR-1 PGP000089 Folkersen L et al. Nat Metab (2020) Proteinase-activated receptor 1 (PAR-1) serum levels blood protein measurement 552,203 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000273/ScoringFiles/PGS000273.txt.gz
PGS000281 RETN PGP000089 Folkersen L et al. Nat Metab (2020) Resistin (RETN) serum levels blood protein measurement 552,003 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000281/ScoringFiles/PGS000281.txt.gz
PGS000280 REN PGP000089 Folkersen L et al. Nat Metab (2020) Renin (REN) serum levels blood protein measurement 552,079 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000280/ScoringFiles/PGS000280.txt.gz
PGS000279 RAGE PGP000089 Folkersen L et al. Nat Metab (2020) Receptor for advanced glycosylation end products (RAGE) serum levels blood protein measurement 552,299 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000279/ScoringFiles/PGS000279.txt.gz
PGS000278 PTX3 PGP000089 Folkersen L et al. Nat Metab (2020) Pentraxin-related protein PTX3 (PTX3) serum levels blood protein measurement 552,475 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000278/ScoringFiles/PGS000278.txt.gz
PGS000277 PSGL-1 PGP000089 Folkersen L et al. Nat Metab (2020) P-selectin glycoprotein ligand 1 (PSGL-1) serum levels blood protein measurement 552,166 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000277/ScoringFiles/PGS000277.txt.gz
PGS000276 PlGF PGP000089 Folkersen L et al. Nat Metab (2020) Placenta growth factor (PlGF) serum levels blood protein measurement 552,276 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000276/ScoringFiles/PGS000276.txt.gz
PGS000287 TNF-R1 PGP000089 Folkersen L et al. Nat Metab (2020) Tumor necrosis factor receptor 1 (TNF-R1) serum levels blood protein measurement 552,318 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000287/ScoringFiles/PGS000287.txt.gz
PGS000286 TM PGP000089 Folkersen L et al. Nat Metab (2020) Thrombomodulin (TM) serum levels blood protein measurement 552,242 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000286/ScoringFiles/PGS000286.txt.gz
PGS000285 TF PGP000089 Folkersen L et al. Nat Metab (2020) Tissue factor (TF) serum levels blood protein measurement 552,229 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000285/ScoringFiles/PGS000285.txt.gz
PGS000284 ST2 PGP000089 Folkersen L et al. Nat Metab (2020) ST2 protein (ST2) serum levels blood protein measurement 552,007 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000284/ScoringFiles/PGS000284.txt.gz
PGS000283 SPON1 PGP000089 Folkersen L et al. Nat Metab (2020) Spondin-1 (SPON1) serum levels blood protein measurement 552,704 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000283/ScoringFiles/PGS000283.txt.gz
PGS000292 TRANCE PGP000089 Folkersen L et al. Nat Metab (2020) TNF-related activation-induced cytokine (TRANCE) serum levels blood protein measurement 552,091 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000292/ScoringFiles/PGS000292.txt.gz
PGS000291 TRAIL-R2 PGP000089 Folkersen L et al. Nat Metab (2020) TNF-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) serum levels blood protein measurement 552,199 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000291/ScoringFiles/PGS000291.txt.gz
PGS000290 TRAIL PGP000089 Folkersen L et al. Nat Metab (2020) TNF-related apoptosis-inducing ligand (TRAIL) serum levels blood protein measurement 552,280 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000290/ScoringFiles/PGS000290.txt.gz
PGS000295 VEGF-D PGP000089 Folkersen L et al. Nat Metab (2020) Vascular endothelial growth factor D (VEGF-D) serum levels blood protein measurement 551,906 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000295/ScoringFiles/PGS000295.txt.gz
PGS000294 VEGF-A PGP000089 Folkersen L et al. Nat Metab (2020) Vascular endothelial growth factor A (VEGF-A) serum levels blood protein measurement 552,071 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000294/ScoringFiles/PGS000294.txt.gz
PGS000293 U-PAR PGP000089 Folkersen L et al. Nat Metab (2020) Urokinase plasminogen activator surface receptor (U-PAR) serum levels blood protein measurement 552,049 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000293/ScoringFiles/PGS000293.txt.gz
PGS000289 TNFSF14 PGP000089 Folkersen L et al. Nat Metab (2020) Tumor necrosis factor ligand superfamily member 14 (TNFSF14) serum levels blood protein measurement 552,049 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000289/ScoringFiles/PGS000289.txt.gz
PGS000288 TNF-R2 PGP000089 Folkersen L et al. Nat Metab (2020) Tumor necrosis factor receptor 2 (TNF-R2) serum levels blood protein measurement 552,186 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000288/ScoringFiles/PGS000288.txt.gz
PGS000282 SCF PGP000089 Folkersen L et al. Nat Metab (2020) Stem cell factor (SCF) serum levels blood protein measurement 552,421 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000282/ScoringFiles/PGS000282.txt.gz
PGS000243 GDF-15 PGP000089 Folkersen L et al. Nat Metab (2020) Growth/differentiation factor 15 (GDF-15) serum levels blood protein measurement 552,229 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000243/ScoringFiles/PGS000243.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000665 PGS000244 (GH) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Growth hormone (GH) serum levels R² difference (PGS+covariates vs. covariates only): 0.00246
: 0.32546
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000666 PGS000254 (IL-8) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Interleukin-8 (IL-8) serum levels : 0.03298
R² difference (PGS+covariates vs. covariates only): 0.00298
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000667 PGS000256 (ITGB1BP2) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Melusin (ITGB1BP2) serum levels : 0.00624
R² difference (PGS+covariates vs. covariates only): 0.00324
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000668 PGS000274 (PDGF_subunit_B) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Platelet-derived growth factor subunit B (PDGF_subunit_B) serum levels : 0.00734
R² difference (PGS+covariates vs. covariates only): 0.00434
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000669 PGS000225 (CSF-1) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Macrophage colony-stimulating factor 1 (CSF-1) serum levels : 0.01849
R² difference (PGS+covariates vs. covariates only): 0.00549
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000671 PGS000276 (PlGF) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Placenta growth factor (PlGF) serum levels : 0.09579
R² difference (PGS+covariates vs. covariates only): 0.00679
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000672 PGS000259 (LEP) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Leptin (LEP) serum levels : 0.32983
R² difference (PGS+covariates vs. covariates only): 0.00683
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000673 PGS000280 (REN) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Renin (REN) serum levels : 0.08537
R² difference (PGS+covariates vs. covariates only): 0.00737
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000674 PGS000218 (AGRP) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Agouti-related protein (AGRP) serum levels : 0.0215
R² difference (PGS+covariates vs. covariates only): 0.0075
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000675 PGS000252 (IL-6) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Interleukin-6 (IL-6) serum levels : 0.01995
R² difference (PGS+covariates vs. covariates only): 0.00795
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000676 PGS000287 (TNF-R1) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Tumor necrosis factor receptor 1 (TNF-R1) serum levels : 0.06801
R² difference (PGS+covariates vs. covariates only): 0.00801
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000677 PGS000237 (FABP4) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Fatty acid-binding protein, adipocyte (FABP4) serum levels : 0.14804
R² difference (PGS+covariates vs. covariates only): 0.00804
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000678 PGS000273 (PAR-1) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Proteinase-activated receptor 1 (PAR-1) serum levels : 0.01206
R² difference (PGS+covariates vs. covariates only): 0.00906
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000679 PGS000236 (ESM-1) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Endothelial cell-specific molecule 1 (ESM-1) serum levels : 0.03924
R² difference (PGS+covariates vs. covariates only): 0.00924
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000680 PGS000235 (EGF) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Epidermal growth factor (EGF) serum levels : 0.01262
R² difference (PGS+covariates vs. covariates only): 0.00962
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000681 PGS000260 (LOX-1) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Lectin-like oxidized LDL receptor 1 (LOX-1) serum levels : 0.01745
R² difference (PGS+covariates vs. covariates only): 0.01045
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000682 PGS000277 (PSGL-1) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: P-selectin glycoprotein ligand 1 (PSGL-1) serum levels : 0.01086
R² difference (PGS+covariates vs. covariates only): 0.01086
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000683 PGS000262 (MB) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Myoglobin (MB) serum levels : 0.14211
R² difference (PGS+covariates vs. covariates only): 0.01111
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000684 PGS000240 (FS) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Follistatin (FS) serum levels R² difference (PGS+covariates vs. covariates only): 0.01152
: 0.05152
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000686 PGS000246 (HGF) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Hepatocyte growth factor (HGF) serum levels : 0.0741
R² difference (PGS+covariates vs. covariates only): 0.0131
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000687 PGS000219 (CA-125) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Ovarian cancer-related tumor marker CA 125 (CA-125) serum levels R² difference (PGS+covariates vs. covariates only): 0.01315
: 0.02315
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000688 PGS000288 (TNF-R2) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Tumor necrosis factor receptor 2 (TNF-R2) serum levels : 0.05136
R² difference (PGS+covariates vs. covariates only): 0.01336
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000689 PGS000217 (ADM) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Adrenomedullin (ADM) serum levels : 0.07313
R² difference (PGS+covariates vs. covariates only): 0.01413
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000690 PGS000293 (U-PAR) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Urokinase plasminogen activator surface receptor (U-PAR) serum levels : 0.03628
R² difference (PGS+covariates vs. covariates only): 0.01428
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000691 PGS000231 (CXCL16) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: C-X-C motif chemokine 16 (CXCL16) serum levels : 0.01734
R² difference (PGS+covariates vs. covariates only): 0.01434
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000692 PGS000239 (FGF-23) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Fibroblast growth factor 23 (FGF-23) serum levels : 0.01903
R² difference (PGS+covariates vs. covariates only): 0.01503
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000693 PGS000247 (hK11) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Kallikrein-11 (hK11) serum levels : 0.03621
R² difference (PGS+covariates vs. covariates only): 0.01721
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000694 PGS000261 (mAmP) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Membrane-bound aminopeptidase P (mAmP) serum levels : 0.02085
R² difference (PGS+covariates vs. covariates only): 0.01785
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000695 PGS000227 (CTSD) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Cathepsin D (CTSD) serum levels : 0.09886
R² difference (PGS+covariates vs. covariates only): 0.01786
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000696 PGS000258 (KLK6) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Kallikrein-6 (KLK6) serum levels : 0.03607
R² difference (PGS+covariates vs. covariates only): 0.01807
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000697 PGS000234 (ECP) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Eosinophil cationic protein (ECP) serum levels : 0.023
R² difference (PGS+covariates vs. covariates only): 0.019
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000698 PGS000233 (Dkk-1) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Dickkopf-related protein 1 (Dkk-1) serum levels : 0.02226
R² difference (PGS+covariates vs. covariates only): 0.01926
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000699 PGS000271 (OPG) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Osteoprotegerin (OPG) serum levels : 0.09428
R² difference (PGS+covariates vs. covariates only): 0.02128
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000700 PGS000295 (VEGF-D) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Vascular endothelial growth factor D (VEGF-D) serum levels : 0.0429
R² difference (PGS+covariates vs. covariates only): 0.0219
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000701 PGS000268 (MMP-7) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Matrix metalloproteinase-7 (MMP-7) serum levels : 0.0571
R² difference (PGS+covariates vs. covariates only): 0.0221
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000702 PGS000263 (MCP-1) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Monocyte chemotactic protein 1 (MCP-1) serum levels : 0.04833
R² difference (PGS+covariates vs. covariates only): 0.02333
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000703 PGS000229 (CX3CL1) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Fractalkine (CX3CL1) serum levels : 0.03603
R² difference (PGS+covariates vs. covariates only): 0.02403
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000704 PGS000238 (FAS) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Tumor necrosis factor receptor superfamily member 6 (FAS) serum levels : 0.08826
R² difference (PGS+covariates vs. covariates only): 0.02626
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000705 PGS000279 (RAGE) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Receptor for advanced glycosylation end products (RAGE) serum levels : 0.04312
R² difference (PGS+covariates vs. covariates only): 0.02712
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000706 PGS000283 (SPON1) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Spondin-1 (SPON1) serum levels : 0.06873
R² difference (PGS+covariates vs. covariates only): 0.02773
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000708 PGS000278 (PTX3) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Pentraxin-related protein PTX3 (PTX3) serum levels : 0.03012
R² difference (PGS+covariates vs. covariates only): 0.02812
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000709 PGS000281 (RETN) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Resistin (RETN) serum levels : 0.04427
R² difference (PGS+covariates vs. covariates only): 0.03327
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000710 PGS000286 (TM) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Thrombomodulin (TM) serum levels : 0.08819
R² difference (PGS+covariates vs. covariates only): 0.03619
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000711 PGS000249 (IL-18) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Interleukin-18 (IL-18) serum levels : 0.08863
R² difference (PGS+covariates vs. covariates only): 0.03763
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000712 PGS000228 (CTSL1) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Cathepsin L1 (CTSL1) serum levels : 0.09752
R² difference (PGS+covariates vs. covariates only): 0.03852
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000713 PGS000289 (TNFSF14) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Tumor necrosis factor ligand superfamily member 14 (TNFSF14) serum levels : 0.04311
R² difference (PGS+covariates vs. covariates only): 0.03911
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000714 PGS000250 (IL-1ra) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Interleukin-1 receptor antagonist protein (IL-1ra) serum levels : 0.05359
R² difference (PGS+covariates vs. covariates only): 0.03959
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000715 PGS000292 (TRANCE) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: TNF-related activation-induced cytokine (TRANCE) serum levels : 0.0487
R² difference (PGS+covariates vs. covariates only): 0.0427
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000716 PGS000291 (TRAIL-R2) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: TNF-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) serum levels R² difference (PGS+covariates vs. covariates only): 0.04464
: 0.05164
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000717 PGS000223 (CD40) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Tumor necrosis factor receptor superfamily member 5 (CD40) serum levels : 0.04728
R² difference (PGS+covariates vs. covariates only): 0.04528
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000718 PGS000243 (GDF-15) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Growth/differentiation factor 15 (GDF-15) serum levels R² difference (PGS+covariates vs. covariates only): 0.04577
: 0.19577
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000719 PGS000269 (MPO) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Myeloperoxidase (MPO) serum levels R² difference (PGS+covariates vs. covariates only): 0.04865
: 0.05565
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000720 PGS000272 (PAPPA) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Pappalysin-1 (PAPPA) serum levels : 0.14698
R² difference (PGS+covariates vs. covariates only): 0.04998
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000721 PGS000242 (Gal-3) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Galectin-3 (Gal-3) serum levels : 0.11502
R² difference (PGS+covariates vs. covariates only): 0.05002
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000722 PGS000265 (MMP-10) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Matrix metalloproteinase-10 (MMP-10) serum levels : 0.0618
R² difference (PGS+covariates vs. covariates only): 0.0518
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000724 PGS000290 (TRAIL) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: TNF-related apoptosis-inducing ligand (TRAIL) serum levels : 0.11259
R² difference (PGS+covariates vs. covariates only): 0.05259
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000725 PGS000275 (PECAM-1) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Platelet endothelial cell adhesion molecule (PECAM-1) serum levels : 0.07059
R² difference (PGS+covariates vs. covariates only): 0.05759
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000726 PGS000221 (CCL3) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: C-C motif chemokine 3 (CCL3) serum levels : 0.10469
R² difference (PGS+covariates vs. covariates only): 0.05869
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000727 PGS000285 (TF) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Tissue factor (TF) serum levels : 0.10251
R² difference (PGS+covariates vs. covariates only): 0.06551
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000728 PGS000267 (MMP-3) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Matrix metalloproteinase-3 (MMP-3) serum levels : 0.40253
R² difference (PGS+covariates vs. covariates only): 0.06753
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000729 PGS000224 (CHI3L1) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Chitinase-3-like protein 1 (CHI3L1) serum levels : 0.15424
R² difference (PGS+covariates vs. covariates only): 0.07924
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000730 PGS000230 (CXCL1) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: C-X-C motif chemokine 1 (CXCL1) serum levels : 0.08781
R² difference (PGS+covariates vs. covariates only): 0.07981
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000731 PGS000266 (MMP-12) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Matrix metalloproteinase-12 (MMP-12) serum levels : 0.08867
R² difference (PGS+covariates vs. covariates only): 0.08867
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000732 PGS000294 (VEGF-A) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Vascular endothelial growth factor A (VEGF-A) serum levels : 0.10967
R² difference (PGS+covariates vs. covariates only): 0.08967
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000733 PGS000251 (IL-27) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Interleukin-27 (IL-27) serum levels : 0.11711
R² difference (PGS+covariates vs. covariates only): 0.09911
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000734 PGS000226 (CSTB) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Cystatin-B (CSTB) serum levels : 0.14472
R² difference (PGS+covariates vs. covariates only): 0.10072
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000735 PGS000248 (HSP_27) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Heat shock 27 kDa protein (HSP_27) serum levels : 0.10996
R² difference (PGS+covariates vs. covariates only): 0.10196
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000736 PGS000222 (CCL4) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: C-C motif chemokine 4 (CCL4) serum levels : 0.13833
R² difference (PGS+covariates vs. covariates only): 0.11033
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000737 PGS000255 (IL16) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Pro-interleukin-16 (IL16) serum levels : 0.1446
R² difference (PGS+covariates vs. covariates only): 0.1136
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000738 PGS000264 (MMP-1) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Matrix metalloproteinase-1 (MMP-1) serum levels : 0.2112
R² difference (PGS+covariates vs. covariates only): 0.1192
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000739 PGS000257 (KIM-1) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Kidney injury molecule 1 (KIM-1) serum levels : 0.22579
R² difference (PGS+covariates vs. covariates only): 0.13579
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000740 PGS000232 (CXCL6) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: C-X-C motif chemokine 6 (CXCL6) serum levels R² difference (PGS+covariates vs. covariates only): 0.1496
: 0.1536
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000742 PGS000253 (IL-6RA) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Interleukin-6 receptor subunit alpha (IL-6RA) serum levels : 0.31718
R² difference (PGS+covariates vs. covariates only): 0.28118
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000664 PGS000270 (NT-pro_BNP) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: N-terminal prohormone brain natriuretic peptide (NT-pro_BNP) serum levels R² difference (PGS+covariates vs. covariates only): 0.00108
: 0.07108
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000670 PGS000245 (HB-EGF) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Proheparin-binding EGF-like growth factor (HB-EGF) serum levels R² difference (PGS+covariates vs. covariates only): 0.00607
: 0.00807
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000685 PGS000220 (CCL20) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: C-C motif chemokine 20 (CCL20) serum levels R² difference (PGS+covariates vs. covariates only): 0.01158
: 0.02158
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000707 PGS000241 (GAL) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Galanin peptides (GAL) serum levels : 0.07696
R² difference (PGS+covariates vs. covariates only): 0.02796
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000723 PGS000282 (SCF) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: Stem cell factor (SCF) serum levels : 0.05956
R² difference (PGS+covariates vs. covariates only): 0.05256
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.
PPM000741 PGS000284 (ST2) PSS000364 PGP000089
Folkersen L et al. (2020)
Reported Trait: ST2 protein (ST2) serum levels : 0.32939
R² difference (PGS+covariates vs. covariates only): 0.19039
age + sex + 10 genetic PCs The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both.

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000364 4,678 individuals European
(Swedish)
MDC