| Publication Information (EuropePMC) | |
| Title | Clinical Application of a Novel Genetic Risk Score for Ischemic Stroke in Patients with Cardiometabolic Disease. |
| PubMed ID | 33185476(Europe PMC) |
| doi | 10.1161/circulationaha.120.051927 |
| Publication Date | Nov. 13, 2020 |
| Journal | Circulation |
| Author(s) | Marston NA, Patel PN, Kamanu FK, Nordio F, Melloni GM, Roselli C, Gurmu Y, Weng LC, Bonaca MP, Giugliano RP, Scirica BM, O'Donoghue ML, Cannon CP, Anderson CD, Bhatt DL, Steg PG, Cohen M, Storey RF, Sever P, Keech AC, Raz I, Mosenzon O, Antman EM, Braunwald E, Ellinor PT, Lubitz SA, Sabatine MS, Ruff CT. |
| Polygenic Score (PGS) ID | PGS Name | PGS Publication (PGP) ID | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants | PGS Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000665 | GRS_32 | PGP000125 Marston NA et al. Circulation (2020) | Ischemic stroke | Ischemic stroke stroke |
32 | http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000665/ScoringFiles/PGS000665.txt.gz |
|
PGS Performance Metric ID (PPM ID) |
Evaluated Score |
PGS Sample Set ID (PSS ID) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
PGS Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM001375 | PGS000665 (GRS_32) | PSS000601 | PGP000125 Marston NA et al. (2020) |
Reported Trait: Incident ischemic stroke in individuals with atrial fibrillation | — | — | Hazard Ratio (HR, top vs. bottom tertile): 1.29 [1.01, 1.64] | age, sex, PCs(1-5), hypertension, hyperlipidemia, diabetes mellitus, smoking, bascular disease, congestive heart failure, atrial fibrillation, components of CHA2DS2-VASc score | — |
| PPM001373 | PGS000665 (GRS_32) | PSS000602 | PGP000125 Marston NA et al. (2020) |
Reported Trait: Incident ischemic stroke | — | — | Hazard Ratio (HR, top vs. bottom tertile): 1.24 [1.05, 1.45] Hazard Ratio (HR, intermediate vs. bottom tertile): 1.15 [0.98, 1.36] |
age, sex, PCs(1-5), hypertension, hyperlipidemia, diabetes mellitus, smoking, bascular disease, congestive heart failure, atrial fibrillation | — |
| PPM001374 | PGS000665 (GRS_32) | PSS000602 | PGP000125 Marston NA et al. (2020) |
Reported Trait: Incident ischemic stroke | — | C-index: 0.65 [0.63, 0.66] | — | Clinical variables from the Revised Framingham Stroke Risk score, geographic region | — |
|
PGS Sample Set ID (PSS ID) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS000602 | The endpoint of interest was ischemic stroke. In each trial, ischemic stroke was formally adjudicated by an independent clinical endpoint committee blinded to treatment assignment. | Median = 2.5 years | [ ,
71.7 % Male samples |
Mean = 65.9 years Sd = 9.2 years |
European | — | ENGAGE AF-TIMI 48, FOURIER, PEGASUS-TIMI 54, SAVOR-TIMI 53, SOLID-TIMI 52 | — |
| PSS000601 | All patients with atrial fibrillation and CHADS2 score of 2 or higher who were treated with anticoagulation. The endpoint of interest was ischemic stroke. In each trial, ischemic stroke was formally adjudicated by an independent clinical endpoint committee blinded to treatment assignment. | Median = 2.8 years | [ ,
60.78 % Male samples |
Mean = 70.8 years Sd = 9.1 years |
European | — | ENGAGE AF-TIMI 48 | — |