PGS Publication: PGP000174

Publication Information (EuropePMC)
Title Depression genetic risk score is associated with anhedonia-related markers across units of analysis.
PubMed ID 31537779(Europe PMC)
doi 10.1038/s41398-019-0566-7
Publication Date Sept. 19, 2019
Journal Transl Psychiatry
Author(s) Guffanti G, Kumar P, Admon R, Treadway MT, Hall MH, Mehta M, Douglas S, Arulpragasam AR, Pizzagalli DA.
Released in PGS Catalog: May 28, 2021

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Asian Ancestries
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000767
(GRS14)
 PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
 Depression depressive symptom measurement,
major depressive disorder		 14
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000767/ScoringFiles/PGS000767.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001972 PGS000767
(GRS14)
 PSS000984|
Multi-ancestry (including European)|
62 individuals
 PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
 Reported Trait: Bilateral Nucleus acumbens stress induced reward prediciton error change — — R²: 0.065 PCs(1-2) —
PPM001973 PGS000767
(GRS14)
 PSS000985|
Multi-ancestry (including European)|
63 individuals
 PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
 Reported Trait: Bilateral putamen stress induced reward prediciton error change — — R²: 0.074 PCs(1-2) —
PPM001974 PGS000767
(GRS14)
 PSS000986|
Multi-ancestry (including European)|
73 individuals
 PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
 Reported Trait: Bilateral nucleus acumbens volume — — R²: 0.064 PCs(1-2) —
PPM001975 PGS000767
(GRS14)
 PSS000986|
Multi-ancestry (including European)|
73 individuals
 PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
 Reported Trait: Bilateral putamen volume — — R²: 0.095 PCs(1-2) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000986 — — 73 individuals,
0.0 % Male samples
 — European, Hispanic or Latin American, African unspecified, Asian unspecified, NR — NR —
PSS000984 — — 62 individuals,
0.0 % Male samples
 — European, Hispanic or Latin American, African unspecified, Asian unspecified, NR — NR —
PSS000985 — — 63 individuals,
0.0 % Male samples
 — European, Hispanic or Latin American, African unspecified, Asian unspecified, NR — NR —