PGS Publication: PGP000187

Publication Information (EuropePMC)
Title Using a genetic risk score to calculate the optimal age for an individual to undergo coronary artery calcium screening.
PubMed ID 31104941(Europe PMC)
doi 10.1016/j.jcct.2019.05.005
Publication Date May 9, 2019
Journal J Cardiovasc Comput Tomogr
Author(s) Severance LM, Contijoch FJ, Carter H, Fan CC, Seibert TM, Dale AM, McVeigh ER.
Released in PGS Catalog: May 28, 2021

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000798
(157SNP_GRS)
 PGP000187 |
Severance LM et al. J Cardiovasc Comput Tomogr (2019)
 Coronary heart disease coronary artery disease 157
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000798/ScoringFiles/PGS000798.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002075 PGS000798
(157SNP_GRS)
 PSS001026|
Multi-ancestry (including European)|
6,660 individuals
 PGP000187 |
Severance LM et al. J Cardiovasc Comput Tomogr (2019)
 Reported Trait: Cornary artery calcium (non-zero CAC score) OR: 1.37 [1.29, 1.45] — — Age, sex —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001026 — — 2,647 individuals — European — MESA —
PSS001026 — — 728 individuals — East Asian — MESA —
PSS001026 — — 1,834 individuals — African American or Afro-Caribbean — MESA —
PSS001026 — — 1,451 individuals — Hispanic or Latin American — MESA —