PGS Publication: PGP000213

Publication Information (EuropePMC)
Title The association between a genetic risk score for allergy and the risk of developing allergies in childhood-Results of the WHISTLER cohort.
PubMed ID 29047167(Europe PMC)
doi 10.1111/pai.12824
Publication Date Nov. 22, 2017
Journal Pediatr Allergy Immunol
Author(s) Arabkhazaeli A, Ahmadizar F, Leusink M, Arets HGM, Raaijmakers JAM, Uiterwaal CSPM, van der Ent CK, Maitland-van der Zee AH, Vijverberg SJH.
Released in PGS Catalog: Aug. 26, 2021

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000867
(GRS10_Allergy)
 PGP000213 |
Arabkhazaeli A et al. Pediatr Allergy Immunol (2017)
 Allergy allergic disease 10
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000867/ScoringFiles/PGS000867.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002411 PGS000867
(GRS10_Allergy)
 PSS001091|
European Ancestry|
1,330 individuals
 PGP000213 |
Arabkhazaeli A et al. Pediatr Allergy Immunol (2017)
 Reported Trait: Time to physician-diagnosed allergy in childhood HR: 1.79 [1.06, 3.02] — — — —
PPM002412 PGS000867
(GRS10_Allergy)
 PSS001091|
European Ancestry|
1,330 individuals
 PGP000213 |
Arabkhazaeli A et al. Pediatr Allergy Immunol (2017)
 Reported Trait: Time to physician-diagnosed allergy in childhood HR: 1.89 [1.05, 3.41] — — Age, gender, breastfeeding, family history of asthma, family history of allergies —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001091 Cases were individuals who had been diagnosed by a phsyician with allergic symptoms. Allergic symptoms were diagnoised/defined using the International Classification of Primary Care (ICPC), allergic conjunctivitis (ICPC: F71), allergic rhinitis (ICPC: R97), or eczema/dermatitis (ICPC: S87, S88). Median = 3.6 years
IQR = [1.5, 6.7] years
[
  • 497 cases
  • , 833 controls
]
,
49.2 % Male samples
 Median = 7.0 years
IQR = [4.0, 9.0] years		 European
(Dutch, NR)		 Dutch = 471, NR = 859 WHISTLER —