PGS Publication: PGP000300

Publication Information (EuropePMC)
Title Association of smoking and polygenic risk with the incidence of lung cancer: a prospective cohort study.
PubMed ID 35194190(Europe PMC)
doi 10.1038/s41416-022-01736-3
Publication Date Feb. 22, 2022
Journal Br J Cancer
Author(s) Zhang P, Chen PL, Li ZH, Zhang A, Zhang XR, Zhang YJ, Liu D, Mao C.
Released in PGS Catalog: April 1, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002270
(PRS33_LC)
 PGP000300 |
Zhang P et al. Br J Cancer (2022)
 Lung cancer lung carcinoma 33
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002270/ScoringFiles/PGS002270.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012923 PGS002270
(PRS33_LC)
 PSS009619|
European Ancestry|
345,794 individuals
 PGP000300 |
Zhang P et al. Br J Cancer (2022)
 Reported Trait: Incident lung cancer HR: 1.16 [1.11, 1.22] — — Age, sex, education, Townsend deprivation index, income, BMI, diet, physical activity, alcohol consumption, occupational exposure, passive smoking, relatedness and first 20 principal components of ancestry —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009619 — —
[
  • 1,687 cases
  • , 344,107 controls
]
,
44.1 % Male samples
 Mean = 56.3 years
Sd = 8.0 years		 European — UKB —