PGS Publication: PGP000303

Publication Information (EuropePMC)
Title Genetic variants associated with low-density lipoprotein cholesterol and systolic blood pressure and the risk of recurrent cardiovascular disease in patients with established vascular disease.
PubMed ID 35317921(Europe PMC)
doi 10.1016/j.atherosclerosis.2022.03.006
Publication Date March 11, 2022
Journal Atherosclerosis
Author(s) Groenland EH, Heidemann BE, van der Laan SW, van Setten J, Koopal C, Bots ML, Asselbergs FW, Visseren FLJ, Spiering W, UCC-SMART Study Group.
Released in PGS Catalog: April 1, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002275
(SBP-PRS)
 PGP000303 |
Groenland EH et al. Atherosclerosis (2022)
 Systolic blood pressure systolic blood pressure 425
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002275/ScoringFiles/PGS002275.txt.gz
PGS002274
(LDL-PRS)
 PGP000303 |
Groenland EH et al. Atherosclerosis (2022)
 LDL cholesterol low density lipoprotein cholesterol measurement 279
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002274/ScoringFiles/PGS002274.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012944 PGS002274
(LDL-PRS)
 PSS009627|
European Ancestry|
4,416 individuals
 PGP000303 |
Groenland EH et al. Atherosclerosis (2022)
 Reported Trait: Low-density lipoprotein cholesterol β: 0.18 [0.15, 0.21] — — Age, sex, the first 5 principal components, BMI, T2DM, smoking, alcohol use, systolic blood pressure, eGFR, triglycerides, lipid-lowering medication —
PPM012945 PGS002275
(SBP-PRS)
 PSS009627|
European Ancestry|
4,416 individuals
 PGP000303 |
Groenland EH et al. Atherosclerosis (2022)
 Reported Trait: Systolic blood pressure β: 3.19 [2.6, 3.78] — — Age, sex, the first 5 principal components, BMI, T2DM, smoking, alcohol use, LDL-cholesterol, eGFR, triglycerides, antihypertensive medication —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009627 — — 4,416 individuals,
75.0 % Male samples
 European — UCC-SMART UCC-SMART