PGS Publication: PGP000305

Publication Information (EuropePMC)
Title Young-onset diabetes in Asian Indians is associated with lower measured and genetically determined beta cell function.
PubMed ID 35247066(Europe PMC)
doi 10.1007/s00125-022-05671-z
Publication Date March 5, 2022
Journal Diabetologia
Author(s) Siddiqui MK, Anjana RM, Dawed AY, Martoeau C, Srinivasan S, Saravanan J, Madanagopal SK, Taylor A, Bell S, Veluchamy A, Pradeepa R, Sattar N, Venkatesan R, Palmer CNA, Pearson ER, Mohan V.
Released in PGS Catalog: April 13, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002277
(pPS_Insulin_secretion_1)
 PGP000305 |
Siddiqui MK et al. Diabetologia (2022)
 Type 2 diabetes (based on SNPs associated with insulin secretion) type 2 diabetes mellitus 8
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002277/ScoringFiles/PGS002277.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012948 PGS002277
(pPS_Insulin_secretion_1)
 PSS009629|
South Asian Ancestry|
5,806 individuals
 PGP000305 |
Siddiqui MK et al. Diabetologia (2022)
 Reported Trait: Age at diagnosis (normal BMI) β: 37.31 (16.7) — R²: 0.012 — —
PPM012947 PGS002277
(pPS_Insulin_secretion_1)
 PSS009629|
South Asian Ancestry|
5,806 individuals
 PGP000305 |
Siddiqui MK et al. Diabetologia (2022)
 Reported Trait: Age at diagnosis — — Z: 5.2 — Z-score p-value < 0.0001
PPM012949 PGS002277
(pPS_Insulin_secretion_1)
 PSS009629|
South Asian Ancestry|
5,806 individuals
 PGP000305 |
Siddiqui MK et al. Diabetologia (2022)
 Reported Trait: Age at diagnosis (overweight BMI) β: 32.68 (20.7) — R²: 0.0097 — —
PPM012950 PGS002277
(pPS_Insulin_secretion_1)
 PSS009629|
South Asian Ancestry|
5,806 individuals
 PGP000305 |
Siddiqui MK et al. Diabetologia (2022)
 Reported Trait: Age at diagnosis (obese BMI) β: 18.9 (10.76) — R²: 0.0036 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009629 — — 5,806 individuals — South Asian
(Indian)		 — INSPIRED Dr. Mohan’s Diabetes Specialities Centre (INSPIRED - DMDSC)