PGS Publication: PGP000339

Publication Information (EuropePMC)
Title Association of APOE-Independent Alzheimer Disease Polygenic Risk Score With Brain Amyloid Deposition in Asymptomatic Older Adults.
PubMed ID 35606148(Europe PMC)
doi 10.1212/wnl.0000000000200544
Publication Date May 23, 2022
Journal Neurology
Author(s) Xicota L, Gyorgy B, Grenier-Boley B, Lecoeur A, Fontaine GL, Danjou F, Gonzalez JS, Colliot O, Amouyel P, Martin G, Levy M, Villain N, Habert MO, Dubois B, Lambert JC, Potier MC, INSIGHT pre-AD study group and for the Alzheimer’s Disease Neuroimaging Initiative*.
Released in PGS Catalog: June 29, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002731
(oA-PRS)
 PGP000339 |
Xicota L et al. Neurology (2022)
 Alzheimer's disease Alzheimer disease 17
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002731/ScoringFiles/PGS002731.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014809 PGS002731
(oA-PRS)
 PSS009897|
Ancestry Not Reported|
228 individuals
 PGP000339 |
Xicota L et al. Neurology (2022)
 Reported Trait: Amyloid burden OR: 3.38 [1.02, 11.63] — — — —
PPM014810 PGS002731
(oA-PRS)
 PSS009897|
Ancestry Not Reported|
228 individuals
 PGP000339 |
Xicota L et al. Neurology (2022)
 Reported Trait: Amyloid burden in E4 carriers OR: 44.94 [3.03, 1277.0] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009897 — — 228 individuals,
49.6 % Male samples
 Mean = 76.62 years
Sd = 4.55 years		 Not reported — ADNI —