PGS Publication: PGP000377

Publication Information (EuropePMC)
Title Family history of prostate and breast cancer integrated with a polygenic risk score identifies men at highest risk of dying from prostate cancer before age 75 years.
PubMed ID 36103261(Europe PMC)
doi 10.1158/1078-0432.ccr-22-1723
Publication Date Sept. 14, 2022
Journal Clin Cancer Res
Author(s) Plym A, Zhang Y, Stopsack KH, Jee YH, Wiklund F, Kibel AS, Kraft P, Giovannucci E, Penney KL, Mucci LA.
Released in PGS Catalog: Oct. 19, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000662
(GRS.PCa.269)
 PGP000122 |
Conti DV et al. Nat Genet (2021)
 Prostate cancer prostate carcinoma 269
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000662/ScoringFiles/PGS000662.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015500 PGS000662
(GRS.PCa.269)
 PSS009964|
Multi-ancestry (including European)|
10,120 individuals
 PGP000377 |
Plym A et al. Clin Cancer Res (2022)
|Ext.		 Reported Trait: Risk of prostate cancer with family history of prostate or breast cancer — — Hazard Ratio (HR, top vs. bottom quartile): 6.95 [5.57, 8.66] Age (underlying time-scale), calendar period of DNA collection (1993-1999, 2005-2006), and genetic ancestry (principal components 1-3) —
PPM015501 PGS000662
(GRS.PCa.269)
 PSS009964|
Multi-ancestry (including European)|
10,120 individuals
 PGP000377 |
Plym A et al. Clin Cancer Res (2022)
|Ext.		 Reported Trait: Prostate cancer death with family history of prostate or breast cancer — — Hazard Ratio (HR, top vs. bottom quartile): 4.84 [2.59, 9.03] Age (underlying time-scale), calendar period of DNA collection (1993-1999, 2005-2006), and genetic ancestry (principal components 1-3) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009964 — — 10,120 individuals,
100.0 % Male samples
 Median = 65.3 years European, Not reported 99% European HPFS —