| Publication Information (EuropePMC) | |
| Title | Association of Prostate-Specific Antigen Levels with Prostate Cancer Risk in a Multiethnic Population: Stability over Time and Comparison with Polygenic Risk Score. |
| PubMed ID | 36126957(Europe PMC) |
| doi | 10.1158/1055-9965.epi-22-0443 |
| Publication Date | Sept. 20, 2022 |
| Journal | Cancer Epidemiol Biomarkers Prev |
| Author(s) | Chou A, Darst BF, Wilkens LR, Le Marchand L, Lilja H, Conti DV, Haiman CA. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000662 (GRS.PCa.269) |
PGP000122 | Conti DV et al. Nat Genet (2021) |
Prostate cancer | prostate carcinoma | 269 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000662/ScoringFiles/PGS000662.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM015510 | PGS000662 (GRS.PCa.269) |
PSS009970| Multi-ancestry (including European)| 4,448 individuals |
PGP000380 | Chou A et al. Cancer Epidemiol Biomarkers Prev (2022) |Ext. |
Reported Trait: Prostate cancer risk in 10 years | OR: 2.12 [1.55, 2.93] | — | — | — | — |
| PPM015511 | PGS000662 (GRS.PCa.269) |
PSS009970| Multi-ancestry (including European)| 4,448 individuals |
PGP000380 | Chou A et al. Cancer Epidemiol Biomarkers Prev (2022) |Ext. |
Reported Trait: Total prostate cancer risk in 10 years | — | AUROC: 0.932 [0.918, 0.947] | — | — | — |
| PPM015512 | PGS000662 (GRS.PCa.269) |
PSS009970| Multi-ancestry (including European)| 4,448 individuals |
PGP000380 | Chou A et al. Cancer Epidemiol Biomarkers Prev (2022) |Ext. |
Reported Trait: Gleason <=7 prostate cancer risk in 10 years | — | AUROC: 0.943 [0.928, 0.959] | — | — | — |
| PPM015513 | PGS000662 (GRS.PCa.269) |
PSS009970| Multi-ancestry (including European)| 4,448 individuals |
PGP000380 | Chou A et al. Cancer Epidemiol Biomarkers Prev (2022) |Ext. |
Reported Trait: Gleason >=8 prostate cancer risk in 10 years | — | AUROC: 0.942 [0.919, 0.964] | — | — | — |
| PPM015514 | PGS000662 (GRS.PCa.269) |
PSS009970| Multi-ancestry (including European)| 4,448 individuals |
PGP000380 | Chou A et al. Cancer Epidemiol Biomarkers Prev (2022) |Ext. |
Reported Trait: Localized prostate cancer risk in 10 years | — | AUROC: 0.936 [0.918, 0.953] | — | — | — |
| PPM015515 | PGS000662 (GRS.PCa.269) |
PSS009970| Multi-ancestry (including European)| 4,448 individuals |
PGP000380 | Chou A et al. Cancer Epidemiol Biomarkers Prev (2022) |Ext. |
Reported Trait: Non-localized prostate cancer risk in 10 years | — | AUROC: 0.948 [0.922, 0.974] | — | — | — |
| PPM015516 | PGS000662 (GRS.PCa.269) |
PSS009970| Multi-ancestry (including European)| 4,448 individuals |
PGP000380 | Chou A et al. Cancer Epidemiol Biomarkers Prev (2022) |Ext. |
Reported Trait: Lethal prostate cancer risk in 10 years | — | AUROC: 0.961 [0.941, 0.982] | — | — | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS009970 | — | — | [ ,
100.0 % Male samples |
— | European | — | MEC | — |
| PSS009970 | — | — | [ ,
100.0 % Male samples |
— | African American or Afro-Caribbean (African American) |
— | MEC | — |
| PSS009970 | — | — | [ ,
100.0 % Male samples |
— | Native American (Native Hawaiian) |
— | MEC | — |
| PSS009970 | — | — | [ ,
100.0 % Male samples |
— | East Asian (Japanese) |
— | MEC | — |
| PSS009970 | — | — | [ ,
100.0 % Male samples |
— | Hispanic or Latin American (Latino) |
— | MEC | — |