PGS Publication: PGP000432

Publication Information (EuropePMC)
Title The value of genetic data from 665,460 individuals in managing iron deficiency anaemia and suitability to donate blood
PubMed ID 38018286(Europe PMC)
doi 10.1111/vox.13564
Publication Date Feb. 6, 2023
Journal Vox Sanguinis
Author(s) Toivonen J, Allara E, FinnGen, Castrén J, di Angelantonio E, Arvas M.
Released in PGS Catalog: Dec. 15, 2023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003425
(prscs_hemoglobin)
 PGP000432 |
Toivonen J et al. Vox Sanguinis (2023)
 Hemoglobin hemoglobin measurement 1,082,250
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003425/ScoringFiles/PGS003425.txt.gz
PGS003426
(prscs_ferritin)
 PGP000432 |
Toivonen J et al. Vox Sanguinis (2023)
 Ferritin ferritin measurement 1,082,414
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003426/ScoringFiles/PGS003426.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017080 PGS003425
(prscs_hemoglobin)
 PSS010117|
European Ancestry|
13,780 individuals
 PGP000432 |
Toivonen J et al. Vox Sanguinis (2023)
 Reported Trait: Hemoglobin levels in postmenopausal females — — R²: 0.04 — —
PPM017081 PGS003426
(prscs_ferritin)
 PSS010118|
European Ancestry|
21,577 individuals
 PGP000432 |
Toivonen J et al. Vox Sanguinis (2023)
 Reported Trait: Ferritin levels in males — — R²: 0.17 — —
PPM017082 PGS003426
(prscs_ferritin)
 PSS010116|
European Ancestry|
5,403 individuals
 PGP000432 |
Toivonen J et al. Vox Sanguinis (2023)
 Reported Trait: Ferritin levels in postmenopausal females — — R²: 0.15 — —
PPM017083 PGS003426
(prscs_ferritin)
 PSS010117|
European Ancestry|
13,780 individuals
 PGP000432 |
Toivonen J et al. Vox Sanguinis (2023)
 Reported Trait: Ferritin levels in postmenopausal females — — R²: 0.19 — —
PPM017078 PGS003425
(prscs_hemoglobin)
 PSS010118|
European Ancestry|
21,577 individuals
 PGP000432 |
Toivonen J et al. Vox Sanguinis (2023)
 Reported Trait: Hemoglobin levels in males — — R²: 0.07 — —
PPM017079 PGS003425
(prscs_hemoglobin)
 PSS010116|
European Ancestry|
5,403 individuals
 PGP000432 |
Toivonen J et al. Vox Sanguinis (2023)
 Reported Trait: Hemoglobin levels in postmenopausal females — — R²: 0.06 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010116 — — 5,403 individuals,
0.0 % Male samples
 — European
(British)		 — INTERVAL —
PSS010117 — — 13,780 individuals,
0.0 % Male samples
 — European
(British)		 — INTERVAL —
PSS010118 — — 21,577 individuals,
100.0 % Male samples
 — European
(British)		 — INTERVAL —